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Cardiac Disease clinical trials

View clinical trials related to Cardiac Disease.

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NCT ID: NCT03581318 Recruiting - Cardiac Disease Clinical Trials

Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging

Start date: July 20, 2018
Phase:
Study type: Observational

Background: Magnetic resonance imaging (MRI) is an important non-invasive tool to study and diagnose cardiovascular disease. MRI scanners use strong magnetic fields and radio waves to create pictures of body organs. Researchers want to find better MRI methods and new ways of imaging cardiovascular disease and better understand normal and abnormal cardiovascular and brain function. Researchers are also interested in seeing if gadolinium, the commonly used MRI contrast agent, stays in the body long after the MRI was performed. Objectives: To develop new methods for imaging the heart and other organs of the body. To describe cardiovascular diseases using newer MRI methods To look at the relationship between cardiovascular disease and cardiovascular risk factors and other organ systems To look for gadolinium deposits in the brain from prior exams. Eligibility: Healthy people and people with known or suspected cardiovascular disease ages 7 and older may be eligible for this study. Researchers may be particularly interested in those who: - Have suspected or known cardiovascular disease - Were previously exposed to a gadolinium-based contrast agent, - Need to have a heart MRI scheduled - Need a test of the heart or other body part or will be undergoing a future cardiac catheterization Design: There are multiple arms to the study with optional components; therefore, there are multiple variations as to what an individual participant s experience may involve. Participants will have an MRI scan lasting up to 2 hours. The scanner is a large hollow tube. During the scan, there may be loud knocking and buzzing sounds caused by the scanner. Participants will lie on a table that slides in and out of the tube. Their vital signs may be monitored. Participants may have a test of heart electrical activity using wires connected to pads on the skin. Participants may have blood drawn. Participants may be injected with an MRI contrast agent through a plastic tube inserted in the arm.

NCT ID: NCT03571672 Not yet recruiting - Cardiac Disease Clinical Trials

Better Accuracy in EF Assessment With DEFINITY

BENEFIT1
Start date: September 2018
Phase: Phase 3
Study type: Interventional

This is a Phase 3, prospective, open-label, multicenter study to evaluate LVEF measurement accuracy and reproducibility of DEFINITY® contrast-enhanced and unenhanced echocardiography as compared with non-contrast cardiac magnetic resonance imaging (CMR) used as the truth standard.

NCT ID: NCT03544424 Not yet recruiting - Physical Activity Clinical Trials

A Study of Physical Activity paTTerns and Major Health Events in Older People With Implantable Cardiac Devices

PATTErn
Start date: July 1, 2018
Phase:
Study type: Observational

An observational study of physical activity patterns in 150 older adults with cardiac implantable electronic devices (CIED)

NCT ID: NCT03530215 Recruiting - Cancer Clinical Trials

Evaluation of Reporting of Cardio-vascular Adverse Events With Antineoplastic and Immunomodulating Agents (EROCA)

EROCA
Start date: May 2, 2018
Phase:
Study type: Observational

Antineoplastic and immunomodulating agents may lead to various cardio-vascular adverse reactions. This study investigates reports of cardio-vascular toxicities for treatment including Anatomical Therapeutic Chemical (ATC) classification L (antineoplastic agents, endocrine therapy, immunostimulants, and immunosuppressants drugs) in the World Health Organization's (WHO) global database of individual safety case reports (VigiBase).

NCT ID: NCT03492242 Recruiting - Cancer Clinical Trials

Immune CHeckpoint Inhibitors Monitoring of Adverse Drug ReAction

CHIMeRA
Start date: February 1, 2018
Phase:
Study type: Observational

Immune checkpoint inhibitors (ICIs) might have high grade immune-related adverse events (irAEs) from rhumatologic, endocrinologic, cardiac or other system origin. This study investigates reports of drug induced irAEs with treatment including anti-PD1, Anti-PDL-1, and Anti-CTLA4 classes using the World Health Organization (WHO) database VigiBase and the french database Base Nationale de PharmacoVigilance (BNPV).

NCT ID: NCT03466255 Recruiting - Clinical trials for Myocardial Infarction

Early Detection of Cardiovascular Disease

VIBE
Start date: December 6, 2016
Phase: N/A
Study type: Observational

The investigators plan to evaluate the correlation between carotid plaque enhancement on Contrast-enhanced ultrasound (CEUS), significant coronary artery disease (CAD), and cardiovascular (CV) outcomes in a systematic manner. The investigators hypothesize that increased levels of CEUS-detected vulnerable carotid plaque will be predictive of CV risk determined by angiography and future cardiovascular events.

NCT ID: NCT03457974 Completed - Dental Caries Clinical Trials

Saliva Profiles in Children With Congenital Heart Disease

Start date: January 1, 2011
Phase: N/A
Study type: Interventional

The purpose of this study was to evaluate whether there are relationships between the salivary oxidative stress status of children with CHD directly dental caries including gender, age, salivary flow rate, salivary pH, salivary buffering capacity and drug intake such as angiotensin-converting enzyme (ACE) inhibitors. If such relationships exist, they might be employed to patient caries -prevention treatment.

NCT ID: NCT03411993 Not yet recruiting - Pregnancy Related Clinical Trials

Prevalence of Rheumatic Heart Disease Among Pregnant Women in Kenya

Start date: January 31, 2018
Phase: N/A
Study type: Observational

There is currently no routine screening for cardiac disease for pregnant women in areas of high prevalence. This study will aim to determine the point prevalence of cardiac disease in women presenting for antenatal care at Moi Teaching and Referral Hospital. More specifically, it will aim to use focused echocardiography as a screening tool to determine the prevalence of cardiac disease among pregnant women attending MTRH antenatal clinic.

NCT ID: NCT03398187 Not yet recruiting - Cardiac Disease Clinical Trials

Cardiac Catheterization in the Management of Pediatric Cardiac Patients at A.U.C.H.

Start date: January 2018
Phase: N/A
Study type: Observational

The aim of this study is to find out and record the indications for diagnostic catheterization as well as for interventional cardiac catheterization in A.U.C.H , and record the outcome in these cases.

NCT ID: NCT03395639 Recruiting - Cardiac Disease Clinical Trials

Edoxaban for Prevention of Blood Vessels Being Blocked by Clots (Thrombotic Events) in Children at Risk Because of Cardiac Disease

Start date: November 16, 2017
Phase: Phase 3
Study type: Interventional

A committee will judge the safety and effectiveness of edoxaban and the regular treatment (standard of care). All children in the study will receive free treatment. They will have a 2 in 3 chance to receive edoxaban, and a 1 in 3 chance to receive the standard of care for preventing blood clots. The study will find out if edoxaban is safer and more effective than the standard of care.