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Microbiome in Lung Cancer and Other Malignancies

Cancer Clinical Trial

Official title:
The Role of Microbiome in Lung Cancer and Other Malignancies

Clinical Trial Summary

To characterize the fecal, skin, nasal and oral microbiome and metabolome in patients with lung cancer and other malignancies, and correlate to treatment response and toxicities of various therapies including immunotherapy, chemotherapy and targeted therapy, etc.

Clinical Trial Description

Patients will be asked to provide nasal, oral and skin swabs, as well as stool samples during their regular clinic visits, at the baseline before desired therapy is given, and at the time when treatment is changed due to either disease progression or unbearable toxicities leading to treatment stop/change. If treatment stop/held is due to toxicities, a 3rd set of samples will be collected when toxicities reduce to less than grade 1. The samples will be subjected to DNA extraction followed by 16S rRNA and/or shotgun sequencing metagenomic analysis. The data will be correlated to clinical response from treatments, toxicities, clinical data (use of antibiotics, PPIs, lab parameters, etc.) and tissue genetic/immunological characteristics (mutations, PDL1 expression, etc.) for review of response. This is not data to be used for treatment of these subjects. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03688347
Study type Observational
Source University of Iowa
Contact
Status Completed
Phase
Start date August 30, 2018
Completion date May 9, 2022
View Details
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