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Clinical Trial Summary

This research study will characterize the nasal, oral, skin and fecal microbiome in patients with lung cancer and other malignancies, and correlate the data with treatment response and toxicities of immunotherapy, the tumor genetic and immune profiling, as well as the multiple -omics in the blood.


Clinical Trial Description

Participants will be asked to provide nasal, oral and skin swabs, as well as stool samples during their regular clinic visits, at the baseline before immunotherapy is given, and at the time when treatment is changed due to either disease progression or unbearable toxicities leading to treatment stop/change. The samples will be subjected to DNA extraction followed by 16S rRNA and/or shotgun sequencing metagenomic analysis. The data will be correlated to clinical response from treatments, toxicities and tissue genetic/immunological characteristics (mutations, PDL1 expression, etc.), as well as multiple -omics (e.g. metabolomics, proteomics, etc.) in the blood. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03688347
Study type Observational
Source University of Iowa
Contact Jun Zhang, MD, PhD
Phone 319-356-2148
Email jun-zhang-1@uiowa.edu
Status Recruiting
Phase
Start date August 30, 2018
Completion date August 2019

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