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CADASIL clinical trials

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NCT ID: NCT06148051 Recruiting - Cadasil Clinical Trials

AusCADASIL: An Australian Cohort of CADASIL

Start date: November 25, 2023
Phase:
Study type: Observational

The aim of this project is to establish an Australian cohort of patients diagnosed with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). This study will examine the clinical features and longitudinal course of CADASIL. Outcome measures include neuropsychological profile, neuroimaging, genetics, blood biomarkers, and retinal imaging.

NCT ID: NCT05902039 Recruiting - Cadasil Clinical Trials

MRI Study of Blood-brain Barrier Function in CADASIL

Start date: April 1, 2021
Phase:
Study type: Observational

Diffusion prepared pseudo-continuous ASL (DP-pCASL) is a newly proposed MRI method to noninvasively measure the function of blood-brain barrier (BBB). The investigators aim to investigate whether the water exchange rate across the BBB, estimated with DP-pCASL, is changed in patients with CADASIL, and to analyze the association between BBB water exchange rate and MRI/clinical features in these patients.

NCT ID: NCT05781139 Recruiting - Dementia Clinical Trials

Comparative Study Between Alzheimer's and Multi-infarct Dementia

Start date: March 10, 2023
Phase:
Study type: Observational

Dementia is a neurological disease that causes cognitive and behavioral impairments that could ultimately interfere with the ability to function at work or to do the usual daily activities. It is recognized as a healthcare and social burden and remains challenging in terms of proper diagnosis and treatment.

NCT ID: NCT05755997 Recruiting - Cadasil Clinical Trials

CERebrolysin In CADASIL

CERICA
Start date: November 29, 2023
Phase: Phase 2
Study type: Interventional

The objective of this trial is the global risk-benefit assessment of Cerebrolysin as compared to Placebo in patients with genetically proven CADASIL. In addition, a traditional approach will be taken based on an evaluation of the separate risk and benefit domains in comparison with placebo.

NCT ID: NCT05734378 Recruiting - Clinical trials for Cerebral Amyloid Angiopathy

Prognosis of Cerebral Small Vessel Disease

PRO-SVD
Start date: December 1, 2020
Phase:
Study type: Observational [Patient Registry]

Prognosis of small vessel disease (SVD) depends on the underlying type of SVD and index manifestation. The aim of this prospective, observational cohort study is to determine the risk of different outcome events among patients with SVD according to the type of index presentation.

NCT ID: NCT05677880 Recruiting - CADASIL Clinical Trials

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study

Start date: June 3, 2022
Phase:
Study type: Observational

This is an observational study to better understand the risk factors and progression of CADASIL, a leading cause of vascular cognitive impairment and dementia (VCID). 500 participants will be enrolled and can expect to be on study for up to 5 years.

NCT ID: NCT05567744 Recruiting - Clinical trials for Cerebral Autosomal Dominant Ateriopathy With Subcortical Infarcts and Leukoencephalopathy

Registry for CADASIL

Start date: June 3, 2022
Phase:
Study type: Observational [Patient Registry]

This study is being done in order to create a registry (list) of people interested in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) research. It may be that you have a family member or other loved one with CADASIL, or that you may have CADASIL or are at risk. Participation means that your name will be added to a list of people who will be invited to participate in future research studies on CADASIL. Participants must be 18 years or older, and will remain on the registry until they request to be removed.

NCT ID: NCT05491980 Recruiting - Ischemic Stroke Clinical Trials

Florida Cerebrovascular Disease Biorepository and Genomics Center

Start date: August 2, 2022
Phase:
Study type: Observational

The purpose of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida, which will include collecting medical history information and blood from subjects affected by cerebrovascular disease. The information and blood samples collected may be used in future research for the study of cerebrovascular disease and to learn about, prevent or treat other health problems.

NCT ID: NCT05473637 Recruiting - Stroke Clinical Trials

Taiwan Associated Genetic and Nongenetic Small Vessel Disease

TAG-SVD
Start date: January 1, 2019
Phase:
Study type: Observational [Patient Registry]

The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD genes, and patients will be divided into genetic or non-genetic groups accordingly. Their clinical features and outcome will be followed for at least 2 years.

NCT ID: NCT05072483 Recruiting - Clinical trials for Cardiovascular Disease

Natural History Study of CADASIL

Start date: April 18, 2022
Phase:
Study type: Observational
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