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CADASIL clinical trials

View clinical trials related to CADASIL.

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NCT ID: NCT06148051 Recruiting - Cadasil Clinical Trials

AusCADASIL: An Australian Cohort of CADASIL

Start date: November 25, 2023
Phase:
Study type: Observational

The aim of this project is to establish an Australian cohort of patients diagnosed with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). This study will examine the clinical features and longitudinal course of CADASIL. Outcome measures include neuropsychological profile, neuroimaging, genetics, blood biomarkers, and retinal imaging.

NCT ID: NCT06072118 Completed - Cadasil Clinical Trials

Adrenomedullin for CADASIL

AMCAD
Start date: January 6, 2022
Phase: Phase 2
Study type: Interventional

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common form of hereditary cerebral small vessel disease, with no proven disease-modifying treatments. Adrenomedullin, a vasoactive peptide, has angiogenic, vasodilation, anti-inflammatory, and anti-oxidative properties and could have triple sites of action on components of the neuro-glial-vascular unit consisting of vessels, microglia and oligodendrocytes or, more specifically, on the white matter oligovascular unit. The aim of the AMCAD trial is to assess the safety and efficacy of Adrenomedullin in CADASIL patients.

NCT ID: NCT05902039 Recruiting - Cadasil Clinical Trials

MRI Study of Blood-brain Barrier Function in CADASIL

Start date: April 1, 2021
Phase:
Study type: Observational

Diffusion prepared pseudo-continuous ASL (DP-pCASL) is a newly proposed MRI method to noninvasively measure the function of blood-brain barrier (BBB). The investigators aim to investigate whether the water exchange rate across the BBB, estimated with DP-pCASL, is changed in patients with CADASIL, and to analyze the association between BBB water exchange rate and MRI/clinical features in these patients.

NCT ID: NCT05793424 Not yet recruiting - Clinical trials for Cerebral Small Vessel Diseases

Establishment of a CSF Bank for the Development of Biomarkers of Smooth Muscle Cell (SMC) Damage in Monogenic Cerebral Small Vessel Disease

CSF-cSVD
Start date: March 2023
Phase:
Study type: Observational

The main objective of this research is to obtain biological markers of smooth muscle cells dysfunction or degeneration in cerebral small vessel diseases. The aim of this research is therefore to build up a biocollection of CSF and blood samples from 1) patients with CADASIL disease (the most common form of cSVD) responsible for an accumulation of the NOTCH3 protein in the microvessel wall, 2) patients with other forms of monogenic cSVD (rarer) which are not responsible for an accumulation of this protein despite the damage to the smooth muscle cells of the vessel wall and 3) control patients without cSVD, collected in the context of care. This bio-collection will allow the identification and assay of markers testifying to the damage of the smooth muscle cells (SMC) in different types of cSVD of hereditary origin, the first of which will be the soluble NOTCH3 protein.

NCT ID: NCT05781139 Recruiting - Dementia Clinical Trials

Comparative Study Between Alzheimer's and Multi-infarct Dementia

Start date: March 10, 2023
Phase:
Study type: Observational

Dementia is a neurological disease that causes cognitive and behavioral impairments that could ultimately interfere with the ability to function at work or to do the usual daily activities. It is recognized as a healthcare and social burden and remains challenging in terms of proper diagnosis and treatment.

NCT ID: NCT05755997 Recruiting - Cadasil Clinical Trials

CERebrolysin In CADASIL

CERICA
Start date: November 29, 2023
Phase: Phase 2
Study type: Interventional

The objective of this trial is the global risk-benefit assessment of Cerebrolysin as compared to Placebo in patients with genetically proven CADASIL. In addition, a traditional approach will be taken based on an evaluation of the separate risk and benefit domains in comparison with placebo.

NCT ID: NCT05734378 Recruiting - Clinical trials for Cerebral Amyloid Angiopathy

Prognosis of Cerebral Small Vessel Disease

PRO-SVD
Start date: December 1, 2020
Phase:
Study type: Observational [Patient Registry]

Prognosis of small vessel disease (SVD) depends on the underlying type of SVD and index manifestation. The aim of this prospective, observational cohort study is to determine the risk of different outcome events among patients with SVD according to the type of index presentation.

NCT ID: NCT05677880 Recruiting - CADASIL Clinical Trials

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study

Start date: June 3, 2022
Phase:
Study type: Observational

This is an observational study to better understand the risk factors and progression of CADASIL, a leading cause of vascular cognitive impairment and dementia (VCID). 500 participants will be enrolled and can expect to be on study for up to 5 years.

NCT ID: NCT05567744 Recruiting - Clinical trials for Cerebral Autosomal Dominant Ateriopathy With Subcortical Infarcts and Leukoencephalopathy

Registry for CADASIL

Start date: June 3, 2022
Phase:
Study type: Observational [Patient Registry]

This study is being done in order to create a registry (list) of people interested in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) research. It may be that you have a family member or other loved one with CADASIL, or that you may have CADASIL or are at risk. Participation means that your name will be added to a list of people who will be invited to participate in future research studies on CADASIL. Participants must be 18 years or older, and will remain on the registry until they request to be removed.

NCT ID: NCT05491980 Recruiting - Ischemic Stroke Clinical Trials

Florida Cerebrovascular Disease Biorepository and Genomics Center

Start date: August 2, 2022
Phase:
Study type: Observational

The purpose of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida, which will include collecting medical history information and blood from subjects affected by cerebrovascular disease. The information and blood samples collected may be used in future research for the study of cerebrovascular disease and to learn about, prevent or treat other health problems.