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Bone Marrow Diseases clinical trials

View clinical trials related to Bone Marrow Diseases.

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NCT ID: NCT03066648 Completed - Leukemia Clinical Trials

Study of PDR001 and/or MBG453 in Combination With Decitabine in Patients With AML or High Risk MDS

Start date: July 6, 2017
Phase: Phase 1
Study type: Interventional

To characterize the safety and tolerability of 1) MBG453 as a single agent or in combination with PDR001 or 2) PDR001 and/or MBG453 in combination with decitabine or azacitidine in AML and intermediate or high- risk MDS patients, and to identify recommended doses for future studies.

NCT ID: NCT02969564 Completed - Prostate Cancer Clinical Trials

18F-NaF-PET/MR vs 99mTc-MDP-SPECT/CT to Detect Bone Metastases in Prostate Cancer Patients.

Start date: May 2016
Phase:
Study type: Observational

The number of metastases in a patient with primary or recurrent prostate cancer has major prognostic implication. The purpose is to compare, in a pilot study, the diagnostic performance of 18F-NaF-PET/MR with respect to the results of the scintigraphy 99mTc-MDP-SPECT/CT (routine exam) for determining the presence or absence of bone lesions in prostate cancer patient, with up to five metastases (oligo-bone metastatic) based on scintigraphy 99mTc-MDP-SPECT/CT. The gold standard will be a combination of clinical follow-up, additional imaging and biopsy, as indicated by the multidisciplinary discussion at the tumor board. The findings from whole-body 99mTc-MDP-SPECT/CT, 18F-NaF-PET/MR, and the combination of the 2 modalities will be categorized by 2 teams of 2 readers as benign or probably benign, equivocal, or malignant or probably malignant and compared with the results of follow-up for JAFROC and ROC analysis.

NCT ID: NCT02876731 Completed - Cancer Clinical Trials

Comparison of NaF PET-CT and Diffusion MRI in the Diagnosis of Bone Metastases (IMMETAOS)

IMMETAOS
Start date: July 2013
Phase: N/A
Study type: Interventional

Prospective, monocentric, comparative, non randomised Primary objective : - to compare the diagnostic accuracy of sodium fluoride PET-CT and MRI using the conventional block and diffusion sequence in the search for bone metastases Secondary objectives : - compare accuracy of MRI diffusion and conventional MRI - explore the evolution of the results of the different types of imaging over time or under treatment for patients with repeated examinations at 6 months

NCT ID: NCT02842775 Completed - Cervical Myelopathy Clinical Trials

Clinical Evaluation and Rehabilitation System for Dynamic Balance Control in Cervical Myelopathy Patients

Start date: January 2016
Phase: N/A
Study type: Interventional

Cervical myelopathy is common among the aging population.One of the complications of cervical myelopathy is balance impairment.In this study, the patients with cervical myelopathy undergo biomechanical, imaging, neurophysiological and functional assessment. Besides, the dynamic balance training is introduced to the patients with cervical decompression surgery.This study is expected to provide important empirical evidence to evaluate the prognosis of the surgery, to further guide the postoperative rehabilitation of myelopathy patients and to improve patients' long-term quality of life.

NCT ID: NCT02826382 Completed - Prostate Cancer Clinical Trials

Preliminary Evaluation of Uptake in Bone Metastases and Biodistribution of [68Ga]P15-041

Start date: September 20, 2016
Phase: Early Phase 1
Study type: Interventional

A phase1 study to demonstrate [68Ga]P15-041 binding to bone metastases in prostate cancer and determination of human dosimetry.

NCT ID: NCT02784652 Completed - Clinical trials for Gastrointestinal Cancer

Efficacy of Radiotherapy in Combination With Zoledronic Acid in Bone Metastasis Patients With Gastrointestinal Tumors

Start date: June 2014
Phase: Phase 2
Study type: Interventional

Bone metastasis causes bone destruction and skeletal related events (SRE) including compression fracture, hypercalcemia, and spinal cord compression. Therefore, palliative treatments for pain control and local control have become important and multidisciplinary multimodality approach is needed for treatment of bone metastasis. The efficacy of radiotherapy (RT) for bone metastasis is well known. And the results that bisphosphonate decreases SRE in patients with solid tumor and multiple myeloma reported. In previous retrospective reports, the combination of local RT and systemic bisphosphonate was more effective than RT alone. Therefore, Investigators designed a phase II study to evaluate the efficacy of RT in combination with zoledronic acid on pain relief and the safety of RT in bone metastasis patients with gastrointestinal tumors.

NCT ID: NCT02774213 Completed - Bone Metastasis Clinical Trials

A Study to Collect Data About Analgesia in Patients With Bone Metastasis

Start date: July 2014
Phase:
Study type: Observational

Up to 180 patients with bone metastasis and requiring analgesic treatment will be followed during 4 to 10 weeks. All patients will continue to receive their cancer therapeutic treatments and be treated for pain relief exactly as they would normally be by the Investigator based on their needs. During their regular visits to the Investigator, patients will complete questionnaires and Clinical Pain Assessments.

NCT ID: NCT02609828 Completed - Cancer Pain Clinical Trials

Phase 3 Study on the Efficacy and Safety of Tanezumab in Patients With Cancer Pain Due to Bone Metastasis Who Are Taking Background Opioid Therapy

Start date: October 28, 2015
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether tanezumab is effective in the treatment of cancer pain due to bone metastasis in patients already taking background opioid therapy.

NCT ID: NCT02511678 Completed - Pain Clinical Trials

Multicenter Study of Cryoablation for Palliation of Painful Bone Metastases

MOTION
Start date: February 15, 2016
Phase: N/A
Study type: Interventional

This study will evaluate the efficacy of cryoablation for palliation of painful metastases in participants with metastatic lesions involving bone who have failed, are not candidates for, or are not experiencing adequate pain relief from current pain therapies (for example, radiation, analgesics).

NCT ID: NCT02410044 Completed - Breast Cancer Clinical Trials

Prospective PRO/QoL Registry for Patients With Bone Metastases of Breast or Prostate Cancer

PROBone
Start date: December 23, 2014
Phase:
Study type: Observational

Evaluation of patient reported outcomes (PRO) / QoL regarding typical ailments in real-life patients with bone metastases treated with osteoprotective agents.