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Bone Marrow Diseases clinical trials

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NCT ID: NCT04952831 Enrolling by invitation - Clinical trials for Cervical Spondylotic Myelopathy

Diffusion MRI in Cervical Spondylotic Myelopathy

Start date: September 1, 2020
Phase:
Study type: Observational

diffusion MRI in evaluates and predicts prognosis in CSM

NCT ID: NCT04498806 Enrolling by invitation - Cervical Myelopathy Clinical Trials

Activity Monitors as a Measure of Physical Function in Degenerative Cervical Myelopathy

Start date: August 13, 2018
Phase: N/A
Study type: Interventional

The investigators objective of this research is to compare activity monitor results with standard of care (SOC) question-based outcome measures for degenerative cervical myelopathy patients before and after treatment with decompression. Understanding of the relationship between activity monitor data and question-based outcome measures in the context of degenerative cervical myelopathy will improve our understanding of the disease and limit the effort to diagnose and monitor it.

NCT ID: NCT04381663 Enrolling by invitation - Cervical Myelopathy Clinical Trials

CSS-Assessing the Course of Degenerative Cervical Spinal Stenosis Using Functional Outcomes

Start date: September 16, 2019
Phase:
Study type: Observational

The study will consist of two parts: - In Study A, objectively assessed physical activity, gait, balance, range of movement of specific joints during walking and neurophysiological findings between patients with cervical spine stenosis (CSS) without myelopathy who will be treated conservatively and patients with stenosis and signs of myelopathy who are candidates for surgical Treatment will be compared. - In Study B, the 6-month changes in the same outcomes in patients treated conservatively (from the first specialist consultation until 6 months later) and in patients treated surgically (preoperative day and 6-month post-operatively) will be quantified.

NCT ID: NCT03513679 Enrolling by invitation - Clinical trials for Cervical Spondylotic Myelopathy

Gait in Adult Patients With Cervical Spondylotic Myelopathy

Start date: March 22, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the effect of cervical decompression surgery on the biomechanics of the lower extremities and spine during balance and gait in patients with cervical spondylotic myelopathy (CSM), before and after surgical intervention, and compare these parameters to an asymptomatic control group. To test our hypothesis that cervical decompression will improve preexisting gait disturbance, a gait analysis using dynamic surface EMG, video motion capture, and force plate analysis will be used. Patients 30 to 70 years old will be eligible for the study. Thirty subjects diagnosed with symptomatic CSM and are deemed appropriate surgical candidates, along with 30 healthy subjects with no spine pathology, will be enrolled in this study. Exclusion criteria include any history of previous lumbar/thoracic surgery or lower extremity surgery, BMI greater than 35, or currently pregnant. Each subject from the surgical group will be evaluated on 3 different occasions: 1) 1 week before surgery, 2) 3 months postoperative, and 3) 12 months postoperative. Control subject will only be evaluated once. Bilateral trunk and lower extremity neuromuscular activity will be measured during a full gait cycle using dynamic surface EMG measurements. Human video motion capture cameras will collect lumbar spine and lower and upper extremity joint angles. Ground reaction forces (GRFs) will be collected from a 5 foot stretch of force platforms in order to define a full gait cycle.

NCT ID: NCT01693770 Enrolling by invitation - Clinical trials for Secondary Malignant Neoplasm of Bone

Primary Pain Palliation in Bone Metastases Treated With Magnetic Resonance-guided Focused Ultrasound

Start date: January 2011
Phase: Phase 1/Phase 2
Study type: Interventional

Magnetic Resonance guided Focused Ultrasound (MRgFUS) has demonstrated to be effective for pain control through thermally-induced cell death and periosteal denervation caused by cortical heating relative to acoustic energy absorption. There is also evidence that a high intensity focused ultrasound beam can penetrate through the cortical bone to the medullary space, producing thermal necrosis of cancer tissue. However, little is known about the potential effects of MRgFUS as first line therapeutic modality for pain palliation in skeletal metastases. Our hypothesis sought to assess the clinical performance of MRgFUS primary treatment of painful bone metastases and determine the potential of this technique for local tumor control.