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Clinical Trial Summary

Study to compare the effects of the investigational new drug (PF-06946860) and a placebo on appetite and to find out how participants with advanced cancer and anorexia feel after receiving repeated subcutaneous (SC-injected under the skin) doses.


Clinical Trial Description

A 6 week double blind study to compare the effects of the investigational new drug (PF-06946860) and a placebo on appetite and to find out how participants with advanced cancer and anorexia feel after receiving repeated doses injected under the skin (subcutaneously). During the initial 6-week treatment period (Part A), a total of 2 doses of study drug or placebo will be administered 3 weeks apart. Each dose contains two injections. Part B is an optional 18-week open-label treatment period where up to 7 doses of study drug may be administered. Part B does not include placebo. Assessments include: - Measure the impact of the study drug on appetite, fatigue, and pain questionnaires - Body weight measurements - Blood samples to evaluate safety and additional endpoints including the amount of the study drug in the blood and the effects of the study drug on levels of a specific cytokine. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04803305
Study type Interventional
Source Pfizer
Contact
Status Completed
Phase Phase 1
Start date May 11, 2021
Completion date August 9, 2022

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