Muscle Protein Synthesis Clinical Trial
Official title:
Influence of Carbohydrate on Amino Acid Absorption From Dietary Protein
10 young males will be recruited to participate in a randomized double blinded crossover
study to investigate the influence of concomitant intake of two different types of
carbohydrate with protein hydrolysate on the absorption kinetics of protein-derived amino
acids and the impact on myofibrillar protein synthesis. During the trial days the subjects
will perform a bout of whole body resistance exercise and ingest a supplement of meat
hydrolysate labeled with D5-phenylalanine together with randomized and double blinded type of
carbohydrate consisting of either glucose or cluster dextrin.
The primary outcome is the time to obtain peak concentration of D5-phenylalanine after intake
of meat hydrolysate with either glucose or cluster dextrin.
Hypotheses:
I) The cluster dextrin will increase the absorption of the amino acids from the meat
hydrolysate, and thereby result in a faster rise and a higher peak in plasma amino acid
concentration in the postprandial period.
II) The meat hydrolysate will increase the protein synthesis rate to a higher extent when
combined with cluster dextrin than with glucose.
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