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Trial of PCSK9 Inhibition in Patients With Acute Stroke and Symptomatic Intracranial Atherosclerosis — TOPICAL-MRI  

Acute Ischemic Stroke Clinical Trial

Official title:
Trial of PCSK9 Inhibition in Patients With Acute Stroke and Symptomatic Intracranial Atherosclerosis - a Prospective, Randomized, Open-label, Blinded End-point Study With High-resolution MR Vessel Wall Imaging

Clinical Trial Summary

This study will evaluate whether low-density lipoprotein (LDL-C) lowering with alirocumab results in greater change from baseline in intracranial atherosclerotic plaque at week 26 than control in adults with acute ischemic stroke from intracranial atherosclerosis taking lipid lowering therapy.

Clinical Trial Description

In this trial, we will conduct a prospective, randomized, open-label, blinded end-point study using high-resolution MRI in patients with acute ischemic stroke from intracranial atherosclerosis to evaluate the efficacy and safety of alirocumab. We hypothesis that additional alirocumab treatment on a background of statin therapy could result in greater stabilization of intracranial plaque and regression of arterial stenosis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05001984
Study type Interventional
Source Chang Gung Memorial Hospital
Contact Yenchu Huang, MD
Phone +88653621000
Email yenchu.huang@msa.hinet.net
Status Recruiting
Phase Phase 2
Start date August 1, 2021
Completion date December 31, 2024
View Details
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