View clinical trials related to Wounds and Injuries.
Filter by:The goal of this experimental observation study is to figure out differently expressed biomarkers in lesion tissues in traumatic brain injury or hypertension intracranial hemorrhage patients. The main questions it aims to answer is: - Which RNA, protein and metabolites are differently expressed in lesion tissues? - What molecular mechanism is participated in TBI or ICH? Participants will be treated by emergency operation, and their lesion tissues will be collected during the operation.
Aim: Investigate whether patients undergoing specialist rehabilitation after complex neurological injury show different functional outcomes if music therapy is included in their rehabilitation program compared to usual care. Background: Patients with complex needs following a brain, spinal cord, and/or peripheral nerve injury often require a period of specialist neurorehabilitation. This involves multiple therapy disciplines, led by a Consultant in Rehabilitation Medicine, Neurology, or Neuropsychiatry. Although music therapy is suggested to enhance neuroplasticity and recovery in patients with brain injury, it is not routinely commissioned in clinical care due to a lack of supportive evidence. Hypothesis: Patients undergoing music therapy in addition to complex specialist rehabilitation show better functional outcomes compared to usual care. Number of participants: 75, aged 16-80 years. Methods: Patients undergo baseline assessments and are randomised to MUSIC or CONTROL Therapy. Both arms receive 1-3 additional therapy sessions per week, matched for duration and number, total 15 hours. After approximately 10-weeks intervention, assessments are repeated. All participants then have access to music therapy until they are discharged from Neurorehabilitation Unit (NRU), with additional qualitative data collection using semi-structured interviews, field notes, staff reports, staff stress surveys, and broader ecological observations. Duration for Participants: From consent to discharge from NRU. Primary Outcome: Change in Functional Independence Measure+Functional Assessment Measure (FIM+FAM), Northwick Park Dependency Scale (NWPDS), and Barthel Activities of Daily Living pre and post 15 hours intervention. Secondary Outcome: Change in quality of life (Flourishing Scale), psychological distress (Hospital Anxiety and Depression Scale, Depression Intensity Scale Circles), social interaction (Sickness Impact Profile Social Interaction Subscale), well-being (WHO Well-Being Index), and communication (Communication Outcomes After Stroke Scale), pre and post 15 hours intervention. Mean difference in well-being (WHO Well-Being Index) throughout the intervention period between music therapy and control therapy groups. Mean difference in post-intervention pain and mood visual analogue scores between music therapy and control therapy groups.
This study will evaluate if Ursolic Acid supplementation may be effective in reducing muscle loss and improving blood sugar control in the SCI community.
Group treatments may be helpful for Veterans who have experienced military sexual trauma (MST). By doing this study, the investigators hope to learn if two different groups: Warrior Renew and Health & Wellness are effective in reducing mental health symptoms in Veterans who have experienced MST and if either is more effective than the other. Participation in this research will last about 16 weeks.
Introduction: The prevalence of hamstring injuries in football is high, causing an increase in the number of casualties and a high socio-economic cost. Currently there are different treatment protocols for this muscle group, but there are often no comparisons of different types of passive, active and combined therapies, and their potential efficacy, in professional football players. Objectives: To compare the efficacy of three different interventions; passive manual therapy, active therapy based on therapeutic exercise and combined therapy, in relation to hamstring injuries in professional football players. Methodology: A simple Randomised Clinical Trial (RCT) was conducted (NCT04935398). After applying the selection criteria, a sample of 66 professional football players was obtained. They were divided into 3 intervention groups (A, B and C) with 22 participants in each group and were given passive manual therapy, active therapy (exercise) and combined therapy (sum of the above). The corresponding tests and questionnaires were evaluated to obtain data on hamstring flexibility and hip range of movement at three time periods: pre, post and post2.
Evaluation of the efficacy (wound epithelialization and time to closure) and tolerance (emergence and nature of adverse event) of the new URGO AWC_008 and URGO AWC_022 dressings in local management of acute and chronic wounds at risk of local infection or with clinical signs of local infection
The main objective of this study is to evaluate the effect on pain of Virtual Reality Therapy as add-on therapy during wound care procedures in adults.
To determine the effect of the eccentric exercise training on injury prevention and hamstring strength in football players.
The aim of this study is to evaluate posterior segment changes in the non-traumatic eye after open globe injury.
Introduction. After observing the lack of lumbo-pelvic control and the difficulty in identifying the musculature used when performing the different dance positions, it was decided to carry out an exercise intervention to strengthen the abdominal musculature and lumbo-pelvic stabilization with dancers of the Dance Conservatory of Murcia. Approximately 40 students in the 6th year of professional dance of the 4 specialties taught will participate in this study. Objectives. To improve abdominal musculature, lumbo-pelvic stability, dance technique and proprioception, to favor the correct integration of the dancer's body scheme and muscular synergies, to reduce the risk of injury and to avoid muscular compensations in the specific Arabesque dance position. Methods. In order to develop the study, two individual and specific assessments of the dancer will be performed, pre and post intervention. In these, data and personal history were collected, assessing joint ranges and asymmetries in the movement of upper and lower limbs, and musculoskeletal assessment of the spine, hip and knee was performed by orthopedic tests. Flexibility of the ischiosural muscles will be evaluated by means of the toes-floor test and the popliteal angle test, and muscle strength in the abdominal and lumbar region for the muscles most involved in the Arabesque movement. In addition, core stability will be assessed by specific tests and hip and knee extension range along with the increase in lumbar curve when performing Arabesque. The intervention will be carried out through group sessions of 4 to 6 participants, and exercises aimed at muscle strengthening and improving lumbo-pelvic stability will be taught. The intervention will be performed 1 hour per week, with each group, for 2 months and they will be instructed to work this routine two hours per week at home.