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Treatment Adherence clinical trials

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NCT ID: NCT06373471 Recruiting - Quality of Life Clinical Trials

Improving Quality of Life in Older Patients With Frailty and Hematological Cancer Through Geriatric Assessment

IMPROVE
Start date: April 2, 2024
Phase: N/A
Study type: Interventional

The Improve study is a randomized controlled trial investigating the efficacy of adding comprehensive geriatric assessment and treatment to standard of care compared with standard of care in older, frail patients with hematological cancer. The investigators aim to recruit 152 study participants who will be randomized 1:1 to intervention- or control group. Study participants in the intervention group will receive the intervention comprehensive geriatric assessment and treatment integrated in the cancer treatment. Study participants in the control group will receive cancer treatment and evaluation of comorbidity and frailty as is usual standard at Department of Hematology. Primary endpoint is elderly functional Index at 12 weeks.

NCT ID: NCT06146530 Recruiting - Treatment Adherence Clinical Trials

Cerina-A Pilot Randomized Controlled Trial

Cerina
Start date: April 24, 2023
Phase: N/A
Study type: Interventional

The goal of this pilot Randomized Controlled Trial is twofold: 1) To learn about the feasibility and usefulness of a mobile application for generalised anxiety symptoms (Cerina); 2) To test the preliminary effects of Cerina in reducing generalized anxiety symptoms compared to a waitlist-control group among Ulster University students presenting mild to moderate symptoms of Generalized Anxiety Disorder (GAD) symptoms. The main research questions are: Is the Cerina app usable and feasible among Ulster University students reporting mild to moderate GAD symptoms? Is there an indication of the effectiveness of the Cerina app in reducing GAD symptoms compared to a wait-list control group among Ulster University students? - After the baseline assessment, eligible and consenting participants will be randomized to either intervention or to the wait-list control group. - Those who are allocated to the intervention group will have access to the Cerina app for 6 weeks. - Those who are in the wait-list control group will wait for 6 weeks until the intervention group finishes the intervention for their access. - The wait-list control group will have access to the services offered by the Ulster University Student Wellbeing team. - Participants in both groups will do mid- (at week 3 after their randomization) and post-assessment (At week 6 after their randomization). - All participants will also be invited to the post-assessment feedback interviews once they complete their post-assessments. The purpose is to have more in-depth information on their views of the Cerina app, the User Interface, the clinical content, the potential facilitators, and barriers to using it in daily life.

NCT ID: NCT05973838 Recruiting - Clinical trials for Substance-Related Disorders

Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention

PRISM
Start date: June 15, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the feasibility and effectiveness of a peer-led, brief, behavioral intervention to improve adherence to medication for opioid use disorder (MOUD) and reduce polysubstance use among patients with OUD and polysubstance use in an underserved, rural area. The intervention is based on behavioral activation (BA) and is specifically designed to be implemented by a trained peer recovery specialist. In this hybrid, Type-1 effectiveness-implementation randomized controlled trial (RCT), the investigators will evaluate the effectiveness and implementation of Peer Activate vs. treatment as usual (TAU) over twelve months.

NCT ID: NCT05869461 Recruiting - Treatment Adherence Clinical Trials

Improving HIV Adherence Care for Key Populations in India

Chetana-PN
Start date: November 30, 2023
Phase: N/A
Study type: Interventional

This study seeks to adapt and pilot test a comprehensive wellness program to address the barriers to engagement in the HIV care continuum among men who have sex with men (MSM) and transgender women (TGW) in India. The content involves an adaptation of the earlier Chetana wellness adherence intervention which was found to successfully improve adherence and viral suppression among mainstream Indian persons living with HIV (PLWH). Based on the initial formative work, the adaptation includes added wellness group content and will be offered in a flexible format. It also uses peer navigators (PN), rather than Master-level counselors, to deliver tailored support at mutually convenient times and places. This PN model has been used successfully by Indian collaborators and in previous research in South Africa to link and retain PLWH in care. The intervention is intended to break the link between stigma and care seeking, which is especially important for key populations (KPs), who must deal with historically hostile legal environments and substantial isolation that further reduces engagement in HIV preventive practices and services . Investigators are conducting this research to address the following aims: 1) To engage community stakeholders in the adaptation and pilot testing of the Chetana-PN wellness adherence intervention for use with Indian MSM and TGW who are living with HIV and who are newly or insufficiently engaged in care. 2a) To assess in a small randomized control trial (RCT) the acceptability and feasibility of the theoretically-guided, adapted intervention and to obtain preliminary effect size estimations for the impact of the intervention on engagement in care, among MSM and TGW. 2b) To characterize participant and navigator experiences in the Chetana-PN intervention and describe the practices that were most successful at overcoming barriers to care with 25 participants who received the Chetana-PN intervention and the peer navigators. These findings will subsequently be used to inform a future RCT designed to establish the efficacy of this adapted Chetana-PN intervention for sexual minorities in India.

NCT ID: NCT05825807 Recruiting - Epilepsy Clinical Trials

Adherence to Pharmacological Antiepileptic Treatment in Adolescence

Start date: November 12, 2020
Phase:
Study type: Observational

Epilepsy and its drug treatment affect fundamental aspects of an adolescent's lifestyle and can have major consequences on self-esteem and sense of identity. For many adolescents it is difficult to live with epilepsy and medication is difficult to accept; the side effects of medication, in particular even small changes in mental status and somatic appearance, are particularly feared and poorly tolerated. While it is true that drug-resistant epilepsies exist (about 30% of cases), it is also true that there exists a pseudo-resistance to drug treatment which is due to inadequate administration or poor adherence to treatment. It is estimated that 21 to 42% of patients on antiepileptic treatment don't adhere to the prescribed therapy. The literature emphasizes that non-adherence to treatment is a crucial problem for people with epilepsy, and that the adolescent population is particularly at risk. As with any chronic drug therapy, the therapeutic relationship plays an important role in the treatment of epilepsy. In adolescence, the communication that occurs within the therapeutic relationship takes on peculiar and specific aspects that go beyond the acquisition of anamnestic data and of what is usually reported explicitly in the interview. Communication must be centered on the adolescent's need for independence. Appropriate communication can make the adolescent feel more supported and can encourage him or her to gain self-awareness and control on decisions regarding his or her illness. For the physician, knowledge of the adolescent's point of view is indispensable in order to provide all the necessary information in an appropriate, understandable, and acceptable way, while at the same time acting as a mediator of communication. The objective of this project is to describe and analyze adolescents' perception of antiepileptic treatment, their awareness of the disease and of the need for drug treatment.

NCT ID: NCT05602376 Recruiting - HIV Infections Clinical Trials

Improving HIV Testing, Linkage, and Retention in Care for Men Through U=U Messaging

Start date: March 31, 2023
Phase: N/A
Study type: Interventional

This study will evaluate the impact of U=U messaging and counseling on gaps in the HIV care cascade for men, including testing uptake and ART initiation (Aim 1), achieving viral suppression and retention in care (Aim 2) in two provinces in South Africa. The U=U message communicates the compelling idea that PLHIV who take ART and have an undetectable viral load (<200 copies/mL) cannot sexually transmit HIV. Additionally, the investigators will conduct a multi-method evaluation to inform future implementation of U=U messaging interventions (Aim 3).

NCT ID: NCT05549362 Recruiting - Aging Clinical Trials

DiAL Health Research Study

Start date: December 2, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to conduct a five-arm pilot and feasibility trial in healthy, young individuals without obesity to evaluate the feasibility and efficacy of dietary intervention approaches to slow mechanisms of aging.

NCT ID: NCT05489068 Recruiting - Clinical trials for Substance-Related Disorders

Motivational Interviewing at Intake vs Intake as Usual on Client Engagement in Addiction Treatment

Start date: March 16, 2022
Phase: N/A
Study type: Interventional

This K23 study is an effectiveness-implementation hybrid type I design to determine the effectiveness of Motivational Interviewing at Intake (MII), relative to intake-as-usual on client engagement and mechanisms of engagement among adults seeking outpatient addiction treatment. We also will obtain personnel feedback on the feasibility of implementing MII into standard practice by having personnel from the addiction treatment study sites complete implementation climate measures before Motivational Interviewing (MI) training and post-clinical trial, as well as an individual interview on implementation feasibility post-trial.

NCT ID: NCT05465408 Recruiting - Breast Cancer Clinical Trials

Culturally Aware AET Non-Initiation Intervention

Start date: July 21, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to examine the feasibility and acceptability of a brief, nurse-led intervention to support breast cancer survivors who have delayed initiation of hormonal therapy or who have concerns about starting hormonal therapy.

NCT ID: NCT05326204 Recruiting - Clinical trials for Gestational Diabetes

1 Versus 2 Hours Post Meal Glucose Monitoring in Gestational Diabetes on Treatment

Start date: December 30, 2021
Phase:
Study type: Observational

A study to compare between 1 and 2 hours post meal blood glucose monitoring in patients with Gestational Diabetes Mellitus requiring treatment.