Stroke Clinical Trial
Official title:
Predictors of Blood Pressure Control and Associations With Cardiovascular Diseases in Individuals With High Blood Pressure: a CALIBER Study
Current guidelines for the clinical management of hypertension in adults recommend to
achieve and maintain blood pressure levels of <140/90 mmHg. However, it is uncertain what
proportion of individuals identified with high blood pressure in primary care actually reach
blood pressure control, what factors are associated with attainment of control and to what
extent blood pressure control attainment is associated with cardiovascular diseases in a
contemporary population of individuals diagnosed with high blood pressure.
The aim of this study is to investigate the extent to which patients achieve blood pressure
control and associated risk factors, time to attainment of blood pressure control and
whether this time is associated with an increased risk of CVD onset, all-cause and
cardiovascular disease and end-stage renal disease.
Status | Active, not recruiting |
Enrollment | 200000 |
Est. completion date | April 2015 |
Est. primary completion date | June 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Patients aged 18 and over - Registered with a participating general practice during the study period - Minimum one year of records prior to study entry meeting CPRD data quality - Diagnosed with high blood pressure in the period January 1997 - March 2010 Exclusion Criteria: - Patients without record of gender - Patients with prior atherosclerotic disease, as recorded in primary care or hospitalisation data - Patients with less than 6 months of follow-up since diagnosis of high blood pressure |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
United Kingdom | University College London | London |
Lead Sponsor | Collaborator |
---|---|
University College, London | National Institute for Health Research, United Kingdom, Wellcome Trust |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | First presentation of cardiovascular disease | First recorded diagnosis of cardiovascular disease during follow-up: myocardial infarction, stroke (haemorrhagic or ischemic), heart failure, coronary revascularisation | 10 years | No |
Primary | All-cause mortality | Recorded death of any cause during follow-up | 10 years | No |
Primary | Cardiovascular mortality | Recorded death due to cardiovascular disease during follow-up | 10 years | No |
Primary | Risk factors for blood pressure control | Investigation of baseline factors associated with blood pressure control attainment during follow-up | 10 years | No |
Primary | Coronary revascularisation | First recorded percutaneous coronary intervention or coronary artery bypass graft (excluding interventions performed within 30 days before or after a diagnosis of myocardial infarction) | 10 years | No |
Secondary | First presentation of cardiovascular disease | First recorded diagnosis of cardiovascular disease during follow-up: stable angina pectoris and atrial fibrillation | 10 years | No |
Secondary | End-stage renal disease | Recorded kidney disease resulting in dialysis or kidney transplantation during follow-up | 10 years | No |
Secondary | Management of high blood pressure | Description of patient management in the 6 months after diagnosis of high blood pressure in terms of: blood pressure lowering medication start, timing and class; smoking cessation; dietary advice; physical activity; weight and total cholesterol decrease; and HDL-cholesterol increase | 6 months after cohort entry | No |
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