Stroke Clinical Trial
Official title:
Atherosclerotic Plaque Texture-Experimental and Clinical Study on the Diagnostic and Therapeutic Strategies of Atherosclerotic Plaque Vulnerability
The aim of the present study is to examine the atherosclerotic plaque stability using in vivo and in vitro techniques and to investigate the influence of exercise, anti-diabetic, lipid-lowering and cannabinoids receptor antagonists on atherosclerotic plaque texture in patients with cardiovascular risk and animals prone to atherosclerosis.
| Status | Completed |
| Enrollment | 300 |
| Est. completion date | January 2009 |
| Est. primary completion date | December 2007 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | Both |
| Age group | 50 Years to 80 Years |
| Eligibility |
Inclusion Criteria: - Carotid atherosclerosis - Femoral atherosclerosis - Cardiovascular risk Exclusion Criteria: - Heart failure - Renal disease - Liver disease - Life-threatening diseases |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Open Label
| Country | Name | City | State |
|---|---|---|---|
| Greece | General Hospital of Thessaloniki "Hippokratio" | Thessaloniki |
| Lead Sponsor | Collaborator |
|---|---|
| Aristotle University Of Thessaloniki |
Greece,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Ultrasound and immunohistochemical parameters of plaque stability; novel cardiovascular risk factors | 3 years | Yes | |
| Secondary | Long-term cardiovascular outcomes | 3 years | Yes |
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