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Induced Hypertension in Acute PRogrESsive Perforating Artery Stroke Using Peripheral Dilute noREpinephrine — PRESSURE  

Stroke, Acute Clinical Trial

Official title:
Induced Hypertension in Acute PRogrESsive Perforating Artery Stroke Using Peripheral Dilute noREpinephrine

Clinical Trial Summary

PRESSURE is a multicenter, prospective, randomized, open, blinded end-point assessed (PROBE) trial, that aims to evaluate the efficacy and safety of drug-induced hypertension using peripheral dilute norepinephrine, in patients with acute ischemic stroke in a perforating artery territory and experiencing early neurological deterioration.

Clinical Trial Description

Perforating artery strokes represent 25% of all ischemic strokes and is a well-known cause of progressive symptoms : 12 to 36% of cases experience early neurological deterioration in hours or days after stroke onset. A possible mechanism is hypoperfusion due to lack of a rapid development of collateral flow because of the terminal distribution of perforating arteries. Moreover, arterioles are maximally dilated within penumbra region, resulting in a cerebral autoregulation failure and a passive dependence of cerebral blood flow on arterial pressure. Thus, induced-hypertension therapy by using vasopressive agents is an attractive therapy to increase the cerebral perfusion pressure and therefore restore blood flow in the ischemic penumbra. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06059144
Study type Interventional
Source University Hospital, Bordeaux
Contact Pauline RENOU
Phone 05-56-79-55-20
Email pauline.renou@chu-bordeaux.fr
Status Not yet recruiting
Phase Phase 3
Start date January 1, 2024
Completion date December 1, 2025
View Details
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