Periodontitis Clinical Trial
Official title:
Periodontitis and Its Microbiological Agents as Prognostic Factors in Patients With Coronary Heart Disease
"Atherosclerosis is an inflammatory disease". The hypothesis of an infectious burden as
trigger or initiator of the inflammatory process in atherosclerosis has been extensively
discussed in the past years. One part of this discussion is focused on the infectious agents
responsible for periodontitis. Several studies have found an association of periodontitis
and/or bacteria related to this disease and atherosclerosis. However, a study focussing on
the prognostic relevance of these factors is missing.
The hypothesis of this study is that periodontitis is a prognostic relevant risk factor for
patients with angiographically proven coronary heart disease. Furthermore, the infectious
pathogen burden by PCR-detection of periodontal pathogens will be evaluated as a prognostic
factor.
960 consecutive patients with angiographically proven coronary heart disease will be
included in this study. After inclusion of patients an extensive periodontal examination
including PCR-sampling for 11 bacteria (Porphyromonas gingivitis, Actinobacillus
actinomycetemcomitans, and others) will be performed. After 12 months patient will be follow
up for any major adverse events (cardiovascular death, myocardial infarction, stroke).
If this study will find a relation of periodontitis or its microbiological agents to
cardiovascular outcome of patients with coronary heart disease, further studies are
necessary to investigate potential therapeutic consequences for patients with CHD and
periodontitis.
n/a
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