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Parkinson Disease clinical trials

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NCT ID: NCT03732898 Not yet recruiting - Clinical trials for Parkinson's Disease (PD)

Coordinated Reset Deep Brain Stimulation

Start date: November 30, 2018
Phase: N/A
Study type: Interventional

The study will explore the viability of an alternative programming strategy in Deep Brain Stimulation (DBS) for patients with Parkinson's Disease (PD).

NCT ID: NCT03727529 Not yet recruiting - Parkinson Disease Clinical Trials

Immersive Virtual Reality to Improve Gait in Parkinson's Disease

Start date: January 2019
Phase: N/A
Study type: Interventional

Parkinson's Disease (PD) patients suffer from gait impairments responsible for falls and bad quality of life: reduced speed and stride length, randomness in stride duration variability (reduced Long-Range Autocorrelations (LRA)). On the other hand, treadmill walking has shown long-term effectiveness on PD patients' gait and quality of life. The purpose of this single blinded randomized controlled trial is to study the effect of a combination of immersive virtual reality and treadmill walking on LRA.

NCT ID: NCT03727295 Not yet recruiting - Clinical trials for Oxidative Stress is an Important Cause of Parkinson's Disease

Idebenone Treatment of Early Parkinson's Diseasesymptoms

Start date: January 1, 2019
Phase: Phase 4
Study type: Interventional

On May 30,2018 ,Investigators intend to conduct a multicenter, randomized, double-blind, placebo-controlled study of idebenone in the treatment of early-stage Parkinson's disease with motor and non-motor symptoms which is to observe the therapeutic effect of idebenone on motor symptoms and non-motor symptoms in patients with early Parkinson's disease。

NCT ID: NCT03724734 Not yet recruiting - Parkinson Disease Clinical Trials

Trial of Adaptive Deep Brain Stimulation

Start date: January 2019
Phase: N/A
Study type: Interventional

Currently, treatment of Parkinson's Disease with deep brain stimulation (DBS) uses continuous high frequency stimulation. The investigators have previously shown that by controlling the stimulation using feedback from the brain and only delivering stimulation when needed side-effects like speech disturbance can be reduced. Here the investigators contrast conventional DBS with adaptive DBS while patients are awake and sleeping.

NCT ID: NCT03717376 Not yet recruiting - Parkinson Disease Clinical Trials

Movement Disorders and Early Maladaptive Schemas

Start date: October 18, 2018
Study type: Observational

Functional neurological disorders (FND) are neurological symptoms that cannot be explained by a lesion or related to an identified dysfunction of the central nervous system. FND are under-diagnosed, although common and highly disabling. Childhood trauma events are found in 30% to 80% of FND patients, and are more common in people with functional neurological disorder than in healthy controls and patient controls. Overall, risks factors, perpetuating factors and maintaining factors have been described in FND, although none of the studies have analysed the prevalence of Early Maladaptive Schemas (EMS) in these patients. EMS, as measured with the Young Schema Questionnaire (YSQ), are proposed to underlie a variety of mental health problems, in particular Personality Disorders. We hypothesize that some of these early maladaptive schemas may participate in the psychopathology and severity of FND. The main outcome of this study is to assess the prevalence of early maladaptive schemas in patients presenting with Functional Movement Disorders in comparison to patients presenting with Parkinson's Disease or Organic Dystonia. The secondary outcomes are to further analyse the underlying relation of these early maladaptive schemas and (i) the severity of the motor symptoms, (ii) anxiety and/or depression, (iii) the occurrence of childhood trauma events in our participants.

NCT ID: NCT03716570 Not yet recruiting - Parkinson's Disease Clinical Trials

A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB054 in Japanese Participants With Parkinson's Disease

Start date: February 1, 2019
Phase: Phase 1
Study type: Interventional

The primary objective of this study is to evaluate the safety and tolerability of a range of single and 13 repeated doses of BIIB054, administered as intravenous (IV) infusion, in Japanese participants with Parkinson's disease (PD). The secondary objectives are to evaluate the immunogenicity, and serum pharmacokinetics (PK) profile of BIIB054 after single and multiple dose administration.

NCT ID: NCT03716258 Not yet recruiting - Parkinson Disease Clinical Trials

Characterizing Biomarkers of Early Parkinson's Disease Progression (TREG)

Start date: December 1, 2018
Study type: Observational

The purpose of this study is to look at a blood marker of inflammation in early untreated Parkinson's disease.

NCT ID: NCT03714854 Not yet recruiting - Parkinson Disease Clinical Trials

Study of Motor Control Mechanisms in DBS-implanted Parkinson's Disease Patients

Start date: November 2018
Phase: N/A
Study type: Interventional

Akinesia is one of the most prominent symptom in Parkinson's Disease (PD) patients. It typically consists in a inability to initiate voluntary movement, and it affects patients' quality of life. This study aims at exploring the influence of Deep Brain Stimulation (DBS) in the quality of motor control, and particularly of voluntary movement initiation, and its neural correlates. They will be evaluated using behavioral and motor tasks together with Transcranial Magnetic Stimulation (TMS) and electrophysiology (EMG and EEG).

NCT ID: NCT03713957 Not yet recruiting - Parkinson Disease Clinical Trials

A Study to Assess the Safety of GRF6021 Infusions in Subjects With Parkinson's Disease and Cognitive Impairment

Start date: November 2018
Phase: Phase 2
Study type: Interventional

This study will evaluate the safety, tolerability, and potential effects on cognition of GRF6021, a plasma-derived product, administered as an intravenous (IV) infusion, to subjects with Parkinson's disease and cognitive impairment.

NCT ID: NCT03711955 Not yet recruiting - Parkinson Disease Clinical Trials

Comparing the Effects of Instability Resistance Training Versus Aerobic Training on Cognitive and Motor Improvements Found in Parkinson's Disease Participants

Start date: January 5, 2019
Phase: N/A
Study type: Interventional

This study will be looking at the effects that instability resistance training and aerobic training, individually, have on the improvement of various motor and cognitive impairments present in individuals with Parkinson' disease. There will be 25-30 participants in this study (all of whom have Parkinson's disease). Once passing the eligibility criteria, participants will complete as series of baseline/pre-tests and then be randomly assigned to either the aerobic training group or the instability training group, where they will participate in every training session that occurs in the next 8 consecutive weeks. There will be 3 training sessions a week occurring on non-consecutive days (ex. Monday, Wednesday, Friday) for both training groups (3 aerobic training sessions, 3 instability resistance training sessions). Once the 8 week training intervention has been completed, a series of post-tests will occur exactly once week after (same tests used as in the pre-tests)