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Parkinson's Disease clinical trials

View clinical trials related to Parkinson's Disease.

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NCT ID: NCT03808961 Not yet recruiting - Parkinson's Disease Clinical Trials

Niacin for Parkinsons Disease

NAPS
Start date: April 1, 2019
Phase: N/A
Study type: Interventional

(1) To examine the blood, urine and spinal fluid of persons with Parkinson's to look for evidence of inflammation and; (2) whether 18 months of vitamin B3(niacin or niacinamide) supplementation may reduce the inflammation and/or improve PD motor and non-motor symptoms.

NCT ID: NCT03808675 Not yet recruiting - Parkinson's Disease Clinical Trials

Aerobic Exercise in Parkinson's Disease

LTAE-PD
Start date: April 1, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

Parkinson's disease (PD) is an incurable brain illness that afflicts more than one million Americans, including many aging Veterans. PD places an unbearable burden on the individual due to progressive impairment of movement and mental function. As a result, patients lose critical abilities such as driving and can become isolated. Although drugs and surgery help movement problems, their benefits are temporary and may cause side effects. Drugs provide limited and temporary benefit for cognition and do not prevent dementia. Animal and preliminary human studies on aerobic exercise show promising results in helping a broad spectrum of symptoms. However, due to limited and inconsistent research results, the long term effects of aerobic exercise on brain health and clinical features in PD is unknown. The investigators will conduct a clinical trial to test the long term effects of aerobic exercise on the brain tissue, movement, mental functions, and driving in PD. If effective, aerobic exercise can be implemented immediately as a low cost, easily accessible treatment in PD.

NCT ID: NCT03794661 Not yet recruiting - Parkinson's Disease Clinical Trials

Evaluation of the Infinity Deep Brain Stimulation Electrode Screening Mode Tool

EVIDENT
Start date: February 28, 2019
Phase: N/A
Study type: Interventional

The objective of this clinical investigation is to characterize the clinical performance of Abbott's Clinician Programmer Electrode Screening Mode tool (InformityTM tool) in programming InfinityTM deep brain stimulation (DBS) systems for patients with Parkinson's disease (PD) or essential tremor (ET).

NCT ID: NCT03752346 Completed - Parkinson's Disease Clinical Trials

Multimodal Exercise Program on Parkinson's Disease Patients With Depression

Start date: March 2016
Phase: N/A
Study type: Interventional

Depression symptoms are common in Parkinson's Disease, it affects health-related quality of life. The evidence showed that exercise improved depression and HRQOL in PD patients. However, studies rarely considered the appropriate exercise program for PD patients, we want to find the best exercise program for PD patients.

NCT ID: NCT03727139 Recruiting - Parkinson's Disease Clinical Trials

Rasagiline Tablets Special Drug Use-Results Survey "Survey on Long-term Safety"

Start date: November 1, 2018
Phase:
Study type: Observational

The purpose of this survey is to evaluate the long-term safety of Rasagiline (AZILECT) in patients with Parkinson's disease in daily clinical practice and also collect efficacy information.

NCT ID: NCT03721887 Recruiting - Parkinson's Disease Clinical Trials

Exploit the Neural Source and the Feasibility of Transcranial Direct Current Stimulation for Freezing of Gait in Parkinson's Disease and Multiple System Atrophy

Start date: August 1, 2018
Phase: N/A
Study type: Interventional

In this project, the investigators will deliver a 5-day session of transcranial direct current stimulation (tDCS) to the leg motor cortex of the FOG patients to examine whether the intervention will benefit the patients in a double blind randomized design. Six assessments with different combinations of clinical scaling, gait analysis, electrophysiological investigation and fMRI examinations before and after tDCS will be conducted. The treatment and placebo groups will be crossed over after one-month washout. The investigators will investigate whether the possible tDCS beneficial effect will be different or similar in patients with different electric sources. In addition, how long the possible beneficial effect of tDCS can be consolidated after the 5-day course of stimulation is also crucial. The investigators aim to peep the myth of FOG in PD and MSA by the multi-modality approach and hope the study will benefit the long suffering patients.

NCT ID: NCT03716570 Not yet recruiting - Parkinson's Disease Clinical Trials

A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB054 in Japanese Participants With Parkinson's Disease

Start date: February 1, 2019
Phase: Phase 1
Study type: Interventional

The primary objective of this study is to evaluate the safety and tolerability of a range of single and 13 repeated doses of BIIB054, administered as intravenous (IV) infusion, in Japanese participants with Parkinson's disease (PD). The secondary objectives are to evaluate the immunogenicity, and serum pharmacokinetics (PK) profile of BIIB054 after single and multiple dose administration.

NCT ID: NCT03703570 Recruiting - Parkinson's Disease Clinical Trials

A Study of KW-6356 in Patients With Parkinson's Disease on Treatment With Levodopa-containing Preparations

Start date: September 29, 2018
Phase: Phase 2
Study type: Interventional

The primary objective of this study is to determine the recommended dose and evaluate the effect of KW-6356 on motor symptoms in Parkinson's disease and the primary endpoint is the change from baseline in Movement disorder society-unified Parkinson's disease rating scale(MDS-UPDRS) partIII score between KW-6356 and placebo in patients with Parkinson's disease on treatment with Levodopa-containing preparations as an adjunctive therapy.

NCT ID: NCT03696589 Active, not recruiting - Parkinson's Disease Clinical Trials

Feasibility and Acceptability of a Physical Activity Behavior Change Intervention for Parkinson's Disease

Preactive-PD
Start date: May 21, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to assess the feasibility, in regards to acceptability and implementation, of the Pre-Active PD intervention for increased high intensity goal-directed aerobic exercise engagement in people with early-stage Parkinson's disease (Hoehn and Yahr stage I & II). In addition, the study aims to explore the effect estimates of the Pre-Active PD intervention on self-efficacy, motivation, stage of behavior change, and physical activity levels in people with early stage Parkinson's disease.

NCT ID: NCT03656796 Recruiting - Parkinson's Disease Clinical Trials

Effects of RAC With Locomotion Training on Cortical Excitability and Behavior in Patients With PD

Start date: April 25, 2018
Phase: N/A
Study type: Interventional

In this study, 51 subjects include 17 freezers,17 non-freezers and 17 aged-matched healthy subjects will be recruited. We will compare the cortical excitability, gait performance, and stepping-in-place performance before and after intervention of auditory cues combined with gait training. The cortical excitability will be assessed by transcranial magnetic stimulation (TMS). The purpose in this study is to investigate the effects of auditory cues with gait training on cortical excitability and rhythmic movements in patients with Parkinson's disease.