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Parkinson's Disease clinical trials

View clinical trials related to Parkinson's Disease.

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NCT ID: NCT03727139 Recruiting - Parkinson's Disease Clinical Trials

Rasagiline Tablets Special Drug Use-Results Survey "Survey on Long-term Safety"

Start date: November 1, 2018
Study type: Observational

The purpose of this survey is to evaluate the long-term safety of Rasagiline (AZILECT) in patients with Parkinson's disease in daily clinical practice and also collect efficacy information.

NCT ID: NCT03721887 Recruiting - Parkinson's Disease Clinical Trials

Exploit the Neural Source and the Feasibility of Transcranial Direct Current Stimulation for Freezing of Gait in Parkinson's Disease and Multiple System Atrophy

Start date: August 1, 2018
Phase: N/A
Study type: Interventional

In this project, the investigators will deliver a 5-day session of transcranial direct current stimulation (tDCS) to the leg motor cortex of the FOG patients to examine whether the intervention will benefit the patients in a double blind randomized design. Six assessments with different combinations of clinical scaling, gait analysis, electrophysiological investigation and fMRI examinations before and after tDCS will be conducted. The treatment and placebo groups will be crossed over after one-month washout. The investigators will investigate whether the possible tDCS beneficial effect will be different or similar in patients with different electric sources. In addition, how long the possible beneficial effect of tDCS can be consolidated after the 5-day course of stimulation is also crucial. The investigators aim to peep the myth of FOG in PD and MSA by the multi-modality approach and hope the study will benefit the long suffering patients.

NCT ID: NCT03716570 Not yet recruiting - Parkinson's Disease Clinical Trials

A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB054 in Japanese Participants With Parkinson's Disease

Start date: February 1, 2019
Phase: Phase 1
Study type: Interventional

The primary objective of this study is to evaluate the safety and tolerability of a range of single and 13 repeated doses of BIIB054, administered as intravenous (IV) infusion, in Japanese participants with Parkinson's disease (PD). The secondary objectives are to evaluate the immunogenicity, and serum pharmacokinetics (PK) profile of BIIB054 after single and multiple dose administration.

NCT ID: NCT03703570 Recruiting - Parkinson's Disease Clinical Trials

A Study of KW-6356 in Patients With Parkinson's Disease on Treatment With Levodopa-containing Preparations

Start date: October 2018
Phase: Phase 2
Study type: Interventional

The primary objective of this study is to determine the recommended dose and evaluate the effect of KW-6356 on motor symptoms in Parkinson's disease and the primary endpoint is the change from baseline in Movement disorder society-unified Parkinson's disease rating scale(MDS-UPDRS) partIII score between KW-6356 and placebo in patients with Parkinson's disease on treatment with Levodopa-containing preparations as an adjunctive therapy.

NCT ID: NCT03696589 Recruiting - Parkinson's Disease Clinical Trials

Feasibility and Acceptability of a Physical Activity Behavior Change Intervention for Parkinson's Disease

Start date: May 21, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to assess the feasibility, in regards to acceptability and implementation, of the Pre-Active PD intervention for increased high intensity goal-directed aerobic exercise engagement in people with early-stage Parkinson's disease (Hoehn and Yahr stage I & II). In addition, the study aims to explore the effect estimates of the Pre-Active PD intervention on self-efficacy, motivation, stage of behavior change, and physical activity levels in people with early stage Parkinson's disease.

NCT ID: NCT03656796 Recruiting - Parkinson's Disease Clinical Trials

Effects of RAC With Locomotion Training on Cortical Excitability and Behavior in Patients With PD

Start date: April 25, 2018
Phase: N/A
Study type: Interventional

In this study, 51 subjects include 17 freezers,17 non-freezers and 17 aged-matched healthy subjects will be recruited. We will compare the cortical excitability, gait performance, and stepping-in-place performance before and after intervention of auditory cues combined with gait training. The cortical excitability will be assessed by transcranial magnetic stimulation (TMS). The purpose in this study is to investigate the effects of auditory cues with gait training on cortical excitability and rhythmic movements in patients with Parkinson's disease.

NCT ID: NCT03651856 Completed - Parkinson's Disease Clinical Trials

Atomoxetine for Freezing of Gait in Parkinson's Disease

Start date: January 2013
Phase: Phase 3
Study type: Interventional

Subjects are being asked to participate in this study to determine the safety and effectiveness of a drug called atomoxetine in the treatment of freezing of gait for Parkinson's Disease patients. Atomoxetine (ATM) is an approved drug currently on the market for the treatment of attention deficit. It works to increase the amount of norepinephrine (a chemical in the brain that helps keep us awake and alert) in our brain. ATM has not been approved by the Food and Drug Administration (FDA) to be used in the treatment of PD, but has been found to be well tolerated in this patient population.

NCT ID: NCT03647137 Recruiting - Parkinson's Disease Clinical Trials

Amyloidopathy, Choinopathy, Dopamine Responsiveness and Freezing of Gait in PD

Start date: June 7, 2016
Study type: Observational

Early stage Parkinson disease (PD) is characterized by a 'honeymoon' phase in terms of responsiveness of motor symptoms, including gait, to dopaminergic pharmacotherapy. Advancing PD is associated with disabling axial motor complications, such as freezing of gait (FoG), with decreased or even refractory dopamine responsiveness in over 50% of patients. The management of dopamine resistant gait problems represents the most important unmet need in PD. This study will related detailed motor testing to brain PET imaging to see if certain molecules (or lack thereof) involved with neurologic transmission in the brain are involved with FoG.

NCT ID: NCT03623841 Recruiting - Stroke Clinical Trials

Training With Exergame and Treadmill on Executive Function and Dual-task Performance

Start date: November 9, 2018
Phase: N/A
Study type: Interventional

This study aimed to investigate the effects of dual-task training with exergame and treadmill on executive function and dual-task performance in individuals with PD and stroke and discuss the correlation between the change values of executive function and dual-task performance after training. Besides, investigate cortical activation after training.

NCT ID: NCT03607695 Recruiting - Parkinson's Disease Clinical Trials

Genetic Influences on Response to Gait Rehabilitation in Parkinson's Disease

Start date: February 1, 2018
Phase: N/A
Study type: Interventional

The aging Veteran population, together with high exposure to Agent Orange or other herbicides during military service, has made diseases such as Parkinson's disease (PD), currently affecting more than 80,000 Veterans, a major health issue in the Veterans' health system. Mobility and cognitive limitations are a common problem in PD and are associated with significant disability, increased fall risk, reduced quality of life, and increased caregiver burden. While less is known about its benefit on cognition, physical therapy has proven to be an effective treatment to mitigate mobility limitations, though the response to rehabilitation interventions is highly variable. The proposed research will inform the investigators' understanding of the impact of certain genetic profiles associated with learning impairments on motor and cognitive benefits in response to gait rehabilitation, and will provide an important foundation for more personalized and improved gait rehabilitation programs for different subgroups of PD patients.