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Parkinson Disease clinical trials

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NCT ID: NCT03645265 Terminated - Parkinson Disease Clinical Trials

Rhythmic Entrainment in Bilingual Speakers With Dysarthria

Start date: September 1, 2018
Phase: N/A
Study type: Interventional

The objectives of this study are to determine i) the effect of rhythmic entrainment of speech with hand gestures and auditory rhythmic cues on intelligibility and speech naturalness in Spanish-accented speakers of English in two pathology groups: ataxic dysarthria and hypokinetic dysarthria secondary to idiopathic Parkinson's disease; and ii) the extent to which speech rate and effort are control parameters of entrainment. These objectives will be achieved with the following specific aims: Specific Aim 1: Determine the effect of three rates of hand gestures and auditory rhythmic cues and the degree to which learning and carry-over occur. Specific Aim 2: Determine the effect of increased speech effort, operationalized as clear speech, and the interaction effect of clear speech with hand gestures and auditory rhythmic cues. Specific Aim 3: Investigate the perception of speech rhythm and its relationship to entrainment.

NCT ID: NCT03387267 Terminated - Stroke Clinical Trials

Videofluoroscopic Swallowing Study (VFSS)

PORSCHE
Start date: October 24, 2017
Phase: N/A
Study type: Interventional

The study procedure of simultaneous VFSS and DDS measurement will be completed in one day and the subject will be followed within 2 business days after the study procedure to monitor for adverse events.

NCT ID: NCT03306329 Terminated - Parkinson's Disease Clinical Trials

DNS-7801 vs. Placebo in Parkinson's Disease

PRIORITY
Start date: September 13, 2017
Phase: Phase 2
Study type: Interventional

This is a randomized, double-blind, two-part placebo-controlled parallel group outpatient treatment study that will utilize standard Parkinson's Disease measures to evaluate the effect of DNS-7801

NCT ID: NCT03185481 Terminated - Clinical trials for Parkinson's Disease With Motor Fluctuations

Safety and Tolerability of PF-06649751 in Parkinson's Disease Patients With Motor Fluctuations

Start date: July 6, 2017
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the long term safety and tolerability of PF-06649751 in Parkinson's disease patients who experience motor-fluctuations.

NCT ID: NCT03178175 Terminated - Parkinson Disease Clinical Trials

Acupuncture for Management of Balance Impairment in Patients With Parkinson's Disease

Start date: December 29, 2016
Phase: N/A
Study type: Interventional

This plan is to evaluate the effectiveness of scalp acupuncture, a modern acupuncture technique specialized to neurological disorders, in managing motor function and body balance for PD patients. This is a randomized, controlled, single-blind clinical trial.

NCT ID: NCT03105401 Terminated - Parkinson Disease Clinical Trials

Phenomenological and Psychopathological Factors Associated to Hallucinations in Parkinson's Disease

HALLUPARK
Start date: May 15, 2017
Phase:
Study type: Observational

This study aims to describe hallucinations prevalence in a sample of patients affected by Parkinson's disease and consulting in an outpatient facility. An unique one hour interview will be offered to volunteers patients. Patients participating to the study will be asked to answer a semi-structured questionnaire searching for hallucinations of all modalities, minor psychotic symptoms and delusions. Psychometric scales will be assessed to search for depressive symptoms, cognitive impairment and specific personality characteristics. The study hypothesis is that hallucinations prevalence in Parkinson's disease is underestimated and is higher than usually described in the scientific literature when all hallucinations modalities and minor hallucinatory phenomenons are searched for.

NCT ID: NCT02894567 Terminated - Parkinson's Disease Clinical Trials

Evaluation of Directional Recording and Stimulation Using spiderSTN

Start date: September 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to provide proof-of-concept that directional stimulation and directional recording, in an intraoperative setting, is perceivable in a subject. The tests will be performed using a dedicated intraoperative lead connected to an external neuro-recorder/stimulator, during a deep brain stimulation implantation surgery.

NCT ID: NCT02885285 Terminated - Parkinson's Disease Clinical Trials

The Impact of Three Distinct Exercise Types on Fatigue, Anxiety, and Depression in Parkinson's Disease

PD&Exercise
Start date: August 2016
Phase: N/A
Study type: Interventional

The purpose of the study is to learn about the impact of exercise on fatigue, anxiety, and depression in Parkinson's disease. It is well established that exercise improves the motor symptoms of Parkinson's disease. However, it is not clear which types of exercise are most beneficial for specific non-motor symptoms.

NCT ID: NCT02875041 Terminated - Parkinson's Disease Clinical Trials

Non-Invasive TMS Neuromodulation for Enduring Balance & Locomotion Restoration in Parkinson's Disease

Start date: August 2016
Phase: N/A
Study type: Interventional

This is a feasibility and exploratory pilot study of adjuvant transcranial magnetic stimulation (TMS) to physical therapy (PT) for locomotion and balance rehabilitation in Parkinson's disease patients.