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Parkinson Disease clinical trials

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NCT ID: NCT03733496 Enrolling by invitation - Parkinson Disease Clinical Trials

Observational, Long-term, Extension Study for Participants of Prior VY-AADC01 or VY-AADC02 Studies

Start date: August 24, 2018
Study type: Observational

An extension study for participants who have completed VY-AADC01 or VY-AADC02 Studies

NCT ID: NCT03638531 Enrolling by invitation - Parkinson Disease Clinical Trials

Long- Term Transcranial Direct Current Stimulation in Parkinson's Disease

Start date: July 30, 2018
Phase: Phase 2
Study type: Interventional

The goal of the proposed research is to determine the influence of transcranial direct current stimulation (tDCS) on long-term motor learning, transfer of motor learning, and cortical function in Parkinson's disease (PD). The project comprises a 2 week training study that will involve tDCS applied during two practice motor tasks with behavioral, clinical, and physiological evaluations at baseline as well as 1, 14 and 28 days following the 2 week training and stimulation period. The findings of the proposed studies should have significant clinical significance and applications to comprehensive intervention therapy development in the treatment of PD.

NCT ID: NCT03633513 Enrolling by invitation - Parkinson Disease Clinical Trials

Parkinson's Disease Inflammatory Biomarker Profiling

Start date: July 10, 2018
Study type: Observational

This study compares a comprehensive panel of immunological biomarkers between Parkinson's disease patients and healthy, environmentally matched participants. This unique study design provides the ability to control for differences in environment between study subjects. The goal of this study is to 1) identify a specific set of immunological markers that correlate with a clinical diagnosis of Parkinson's disease and 2) stratify patients by disease severity using these same biomarkers.

NCT ID: NCT03600740 Enrolling by invitation - Parkinson Disease Clinical Trials

Advancing Pre-operative Targeting for Deep Brain Stimulation in the Globus Pallidus Internus

Start date: August 17, 2018
Phase: N/A
Study type: Interventional

In the proposed pilot project, MRI data will be prospectively collected to show the feasibility of the segmentation algorithm and the potential relation to final lead positioning. Patients will be selected from those undergoing GPi DBS placement. This pilot data will serve as a basis for pursuing funding for a larger trial evaluating the prospective ability of the 3T targeting study to improve outcomes and decrease complications in GPi DBS placement. Improved outcomes and patient experience would be expected to further contribute to our facility as a center of excellence for treatment of movement disorders.

NCT ID: NCT03538262 Enrolling by invitation - Parkinson Disease Clinical Trials

Assessing Tele-Health Outcomes in Multiyear Extensions of PD Trials

Start date: October 1, 2018
Study type: Observational

An observational study to characterize and compare long-term clinical outcomes data collected remotely through periodic tele-visits, interactive smartphone app sessions, and web-based surveys in individuals with Parkinson's Disease (PD) who have completed the interventional phases of the STEADY-PD3 and SURE-PD3 clinical trials.

NCT ID: NCT03473522 Enrolling by invitation - Parkinson Disease Clinical Trials

Effects of tDCS Combined With Therapeutic Exercises in Patients With Parkinson's Disease.

Start date: February 1, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

Parkinson's disease is a progressive, degenerative neurological disease associated with profound changes in the quality of life of its survivors. Therapeutic exercises are widely employed in the attempt to delay or minimize disease progression, characterized by significant motor and sensory deficits. Recent evidence has demonstrated the potential use of transcranial direct current stimulation (TDCs) as a complement to therapeutic exercises. However, few studies have investigated the effects of TDCs combined with therapeutic exercises in patients with Parkinson's disease. This study aims to investigate the effect of TDCs combined with therapeutic exercises in people with Parkinson's disease. Thirty patients will be randomized into two distinct groups to receive either TDCs(anodal) + therapeutic exercises or TDCs (sham) + therapeutic exercises for 24 sessions over a five-week period. The primary clinical outcome (balance) and secondary outcomes (functional capacity, quality of life and perception of overall effect) will be collected before treatment after two and five weeks at month 3 and month 6 after randomization. The data will be collected by a blind examiner to the treatment allocation.

NCT ID: NCT03409120 Enrolling by invitation - Parkinson Disease Clinical Trials

Unlocking Dystonia From Parkinson's Disease With Directional DBS Technology

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

This study occurs during five visits that are already scheduled as part of "Biomarkers to Guide Directional DBS for Parkinson's Disease" ( Identifier: NCT03353688). If participants have dystonia associated with Parkinson's disease, the investigators will consent and administer one additional rating scale (Burke-Fahn-Marsden Dystonia Rating Scale) to assess the severity of dystonia.

NCT ID: NCT03270657 Enrolling by invitation - Parkinson Disease Clinical Trials

Scalar Closed Loop Intraoperative Study

Start date: April 5, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to measure neural activity during deep brain stimulation (DBS). There are two types of neural activity that we will record from DBS electrodes during this study: DBS local evoked potentials (DLEPs) and spontaneous, local field potentials (LFPs). We will measure the effects of varying stimulation parameters on both the neural activity and changes in motor symptoms -- bradykinesia and tremor -- in subjects with Parkinson's disease (PD). Correlating neural activity characteristics with changes in symptoms will improve our understanding of the mechanisms of action of DBS. This intraoperative study will specifically compare our ability to record neural activity using circuitry developed at Duke for this purpose [Kent et al, 2015] to a new, implanted pulse generator (IPG; RC+S) developed by Medtronic. These intraoperative studies will specifically test a preliminary version of the RC+S (that is not designed for implantation), and will lead to a clinical trial assessing the efficacy of the implantable RC+S IPG in PD patients once this device is available and approved for this trial.

NCT ID: NCT03258294 Enrolling by invitation - Parkinson's Disease Clinical Trials

Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease

Start date: January 13, 2016
Phase: Phase 4
Study type: Interventional

This clinical study is a double-blind, randomized, placebo-controlled trial to investigate the effects of melatonin on the sleep disturbance symptoms of Parkinson's disease patients, symptoms which have a significant impact on the quality of life of these patients.

NCT ID: NCT03193268 Enrolling by invitation - Parkinson Disease Clinical Trials

Effects of Intensity-matched Agility and Cycling Exercise Training on PD Patients' Clinical Symptoms, Posture, and Mobility

Start date: October 15, 2017
Phase: N/A
Study type: Interventional

Determine the short-term and lasting effects of intensity-matched exercise programs on level 2-3 PD patients' clinical symptoms, postural control, and mobility. Hypothesis 1. The inclusion of a Borg-scale/heart-rate matched active control group will allow us to test the idea that, in addition to a fitness element, the reflexive movements that chellenge PD patients' sensorimotor system will improve patients' clinical symptoms, posture, and mobility more than fitness training and that such lasting effects will be superior in the agility compared with the fitness-control group. This hypothesis emered from the idea that the favorable results in the currently under review paper may be in part due to a simple conditioning effect instead of a specific motor learning effect caused by the xbox training. 2. If feasible, i.e., if there is a lerge enough pool of patients to randomize, a balance training group will be also added to test the idea that the reflexive actions evoked by the agility program by xbox exergaming still produce superior adaptations vs. the balance group because xbox forces patients to rapidly and reflexively execute movements (respond to cues, prompts), while balance training allows patients to stop, go, stop, and go and disrupt the continous execution of linked movements. The disruptions of movement chains could arise from small losses of balance on the unstabel surfaces, need for patients to re-initiate every movement element of a sequence, planning each movement element. It is not clear yet how it woul be possible to match all three intervention groups on Borg/heart rate intensity.