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Parkinson Disease clinical trials

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NCT ID: NCT03877510 Enrolling by invitation - Parkinson Disease Clinical Trials

Open Label Extension (OLE) Study of the Safety and Clinical Utility of IPX203 in PD Patients With Motor Fluctuations

Start date: April 3, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the long-term safety and clinical utility of IPX203 in the treatment of subjects with advanced Parkinson's disease (PD) who have motor fluctuations.

NCT ID: NCT03827746 Enrolling by invitation - Parkinson Disease Clinical Trials

The Effect of Kinesiophobia on Physical Activity, Balance and Falling in Parkinson's Disease Patients

Start date: April 1, 2018
Study type: Observational

The kinesiophobia; defined as irrational fear of movement, which may occur after painful injury and reduce physical activity. It develops the idea that movement in individuals will cause re-injury and cause additional pain to existing pain. Studies have shown that this situation leads to a decrease in physical fitness, avoidance of activity, decrease in quality of life and even depression in the long term. It is known that functional problems such as balance problems and decrease in physical activity level occur in patients with Parkinson's disease. However, in the literature, there is no study investigating the presence of kinesiophobia in patients with Parkinson's disease. Therefore, the aims of our study were to 1) determine the presence / absence of kinesiophobia in patients with Parkinson's disease 2) determine the relationship between kinesiophobia and falling, balance, physical activity level in the presence of kinesiophobia.

NCT ID: NCT03741920 Enrolling by invitation - Parkinson Disease Clinical Trials

Evaluation of the Personal KinetiGraph™ (PKG™) to Improve Insight Into Parkinson's Disease Status

Start date: May 17, 2017
Phase: N/A
Study type: Interventional

The primary objective is to understand the utility of Personal KinetiGraph movement recording system data in the clinical management of Parkinson's disease (PD) in routine clinical care at a movement disorders clinic. Specifically: 1. Measure medication use and clinical management plan changes in a large, multicenter cohort among participants undergoing a clinical assessment with an MDS in which the MDS reviews the participant's PKG during the clinical assessment in half of the enrolled participants (PKG + Group) and in half of the enrolled participants the MDS completes the clinical assessment without the PKG (PKG- Group). 2. Determine the association between frequency of medication changes, the PKG information, and other clinical assessments among participants with and without a PKG report of their PD motor status available to the clinician at the time of evaluation.

NCT ID: NCT03733496 Enrolling by invitation - Parkinson Disease Clinical Trials

Observational, Long-term, Extension Study for Participants of Prior VY-AADC01 or VY-AADC02 Studies

Start date: August 24, 2018
Study type: Observational

An extension study for participants who have completed VY-AADC01 or VY-AADC02 Studies

NCT ID: NCT03702816 Enrolling by invitation - Parkinson Disease Clinical Trials

The Relationship Between Neuropsychological Testing and MRI, PET and COBRE - Project 1: AIM 2 (GE-180)

Start date: December 13, 2018
Phase: Phase 2
Study type: Interventional

The complex pathological cascades leading to both Alzheimer's disease (AD) and Parkinson's disease (PD) involve, at various points, inflammation. Since inflammation is a treatable symptom, understanding how and when it impacts the brain, and where specifically in the brain, would offer important guidance in the development of new treatments, sorely needed in both diseases. Microglia play an important anti-inflammatory role, and produce a substance, mitochondrial translocator protein (TSPO), whose presence can be used as a marker of regional inflammation. GE180 is a newly developed PET ligand which binds to TSPO and hence can be used in imaging studies to analyze regional inflammation in living patients. In prior studies it has shown regional specificity in multiple sclerosis and brain injury. In the current study, the investigators will be using GE180 to analyze regional and global inflammation in the brains of patients with AD and PD at two time points. The results of the current study will provide enriched understanding of inflammation in these conditions, and potentially provide preliminary data to inform design of future interventional trials.

NCT ID: NCT03697434 Enrolling by invitation - Parkinson Disease Clinical Trials

Acceptability of Palliative Care in Parkinson Disease Care

Start date: November 16, 2018
Phase: N/A
Study type: Interventional

This study will assess the feasibility of using specific criteria to standardize the referral of individuals with Parkinson disease to a group of medical providers known as palliative care specialists. Palliative care specialists provide supportive care to individuals living with serious illnesses. The specialty focuses on providing relief from the symptoms and stress of serious illness.

NCT ID: NCT03638531 Enrolling by invitation - Parkinson Disease Clinical Trials

Long- Term Transcranial Direct Current Stimulation in Parkinson's Disease

Start date: July 30, 2018
Phase: Phase 2
Study type: Interventional

The goal of the proposed research is to determine the influence of transcranial direct current stimulation (tDCS) on long-term motor learning, transfer of motor learning, and cortical function in Parkinson's disease (PD). The project comprises a 2 week training study that will involve tDCS applied during two practice motor tasks with behavioral, clinical, and physiological evaluations at baseline as well as 1, 14 and 28 days following the 2 week training and stimulation period. The findings of the proposed studies should have significant clinical significance and applications to comprehensive intervention therapy development in the treatment of PD.

NCT ID: NCT03633513 Enrolling by invitation - Parkinson Disease Clinical Trials

Parkinson's Disease Inflammatory Biomarker Profiling

Start date: July 10, 2018
Study type: Observational

This study compares a comprehensive panel of immunological biomarkers between Parkinson's disease patients and healthy, environmentally matched participants. This unique study design provides the ability to control for differences in environment between study subjects. The goal of this study is to 1) identify a specific set of immunological markers that correlate with a clinical diagnosis of Parkinson's disease and 2) stratify patients by disease severity using these same biomarkers.

NCT ID: NCT03600740 Enrolling by invitation - Parkinson Disease Clinical Trials

Advancing Pre-operative Targeting for Deep Brain Stimulation in the Globus Pallidus Internus

Start date: August 17, 2018
Phase: N/A
Study type: Interventional

In the proposed pilot project, MRI data will be prospectively collected to show the feasibility of the segmentation algorithm and the potential relation to final lead positioning. Patients will be selected from those undergoing GPi DBS placement. This pilot data will serve as a basis for pursuing funding for a larger trial evaluating the prospective ability of the 3T targeting study to improve outcomes and decrease complications in GPi DBS placement. Improved outcomes and patient experience would be expected to further contribute to our facility as a center of excellence for treatment of movement disorders.

NCT ID: NCT03578653 Enrolling by invitation - Parkinson Disease Clinical Trials

Merging Yoga and Occupational Therapy for Parkinson Disease: Phase 2

MY-OT for PD
Start date: June 1, 2018
Phase: N/A
Study type: Interventional

The full program is focused on identifying and reducing risk factors surrounding falls. Based on previous research, we believe that occupational therapy group classes and adaptive yoga are an ideal pairing to reduce fall risk. The occupational therapy sessions will consist of lecture, group discussion, and activities designed to target biological, behavioral, environmental, and socioeconomic factors that contribute to fall risk specifically for people with Parkinson's disease.