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Parkinson Disease clinical trials

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NCT ID: NCT03847753 Active, not recruiting - Hypertension Clinical Trials

Exploring the Comorbidity Between Mental Disorders and General Medical Conditions

Start date: January 1, 2000
Study type: Observational [Patient Registry]

Mental disorders have been shown to be associated with a number of general medical conditions (also referred to as somatic or physical conditions). The investigators aim to undertake a comprehensive study of comorbidity among those with treated mental disorders, by using high-quality Danish registers to provide age- and sex-specific pairwise estimates between the ten groups of mental disorders and nine groups of general medical conditions. The investigators will examine the association between all 90 possible pairs of prior mental disorders and later GMC categories using the Danish national registers. Depending on whether individuals are diagnosed with a specific mental disorder, the investigators will estimate the risk of receiving a later diagnosis within a specific GMC category, between the start of follow-up (January 1, 2000) or at the earliest age at which a person might develop the mental disorder, whichever comes later. Follow-up will be terminated at onset of the GMC, death, emigration from Denmark, or December 31, 2016, whichever came first. Additionally for dyslipidemia, follow-up will be ended if a diagnosis of ischemic heart disease was received. A "wash-out" period will be employed in the five years before follow-up started (1995-1999), to identify and exclude prevalent cases from the analysis. Individuals with the GMC of interest before the observation period will be considered prevalent cases and excluded from the analyses (i.e. prevalent cases were "washed-out"). When estimating the risk of a specific GMC, the investigators will consider all individuals to be exposed or unexposed to the each mental disorder depending on whether a diagnosis is received before the end of follow-up. Persons will be considered unexposed to a mental disorder until the date of the first diagnosis, and exposed thereafter.

NCT ID: NCT03793491 Active, not recruiting - Parkinson Disease Clinical Trials

Personality, as a Predictive Factor of Therapeutic Response on Quality of Life After Continuous Perfusion of Dopaminergic Drugs, in Parkinson's Disease

Start date: December 18, 2018
Study type: Observational

The aim of the study is to evaluate if patients' personality could be considerate as predictive factor of quality of life after the establishment of continuous infusion of dopaminergic treatments to observe if there are predictive personality's profiles of specific therapeutic response (Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) or continuous infusion).

NCT ID: NCT03779880 Active, not recruiting - Parkinson Disease Clinical Trials

Examining Parkinson's Disease-Related Retirement: Results of Turkey

Start date: May 2, 2018
Study type: Observational

Although Parkinson Disease's (PD) is usually associated with an older patient population, 5% of patients are diagnosed at age 50 and 30% before 65 years of age. This shows that many patients with PD have diagnosed during the active study and have long periods of normal retirement. After the diagnosis of Parkinson's patients, the duration of leaving of employment vary between 0 and 25 years. It was found that patients' full-time working capacity decreased by up to 80% and they quitted earlier than the general population. The disability associated with PD is thought to be a factor in this situation. Nevertheless, the reasons for early retirement are not fully known and more information is needed on the specific problems of PD in order for patients to continue their career. The aim of our study is to examine the impact of Parkinson's disease on retirement and to contribute to Turkey's data. Patients with PD admitted to the Parkinson's disease outpatient clinic, which is the biggest clinic of Turkey about neurology, are included in the study. It is planned to meet with 75 patients on 31/12/2018 and to reach the end of the data collection phase.

NCT ID: NCT03774225 Active, not recruiting - Parkinson Disease Clinical Trials

The Influence of Manual and Verbal Guidance for Therapeutic Results in People With Parkinson's Disease

Start date: December 1, 2017
Phase: N/A
Study type: Interventional

A prospective, single-blind, parallel-group, randomised trial was conducted in Sao Paulo, Brazil. Thrid eight People with Parkinson's Disease were recruited and randomly allocated in two groups: Experimental Group (EG), that performed the balance and gait training based on games from Microsoft Xbox Kinect System ® (MXKS) supported by manual and verbal guidance (MVG) provided by a PT and a control group (CG) that performed an identical training with no MVG during the training.

NCT ID: NCT03741959 Active, not recruiting - Parkinson Disease Clinical Trials

Rehabilitation of Postural Abnormalities in Parkinson's Disease

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

Postural abnormalities (PA) are drug refractory complications in patients with Parkinson's disease (PD) leading to pain, imbalance, gait disorders and fall-related injuries. It ultimately affects the quality of life and the hospitalisation risk. the literature on treatment outcomes is scant. Rehabilitation is the cornerstone in the management of PD patients, especially for drug-refractory complications. However, the current efforts are only partially able to resolve PA in PD. Despite differences in methodologies, the few rehabilitative studies support the benefits of trunk rehabilitation in PD with PA. Priorities for future research include well-design rehabilitation studies on a large population. The early detection and early rehabilitation of PA might avoid fixed irreversible deformities and reduce the complications that can accompany them. It ultimately might improve the quality of life, reduce the risk of fall-related injuries and hospitalisation rate. A single-blind single-blind Randomised Controlled Trial (RCT) will evaluate the effects of trunk rehabilitation on PA severity, function and disability in outpatients with Parkinson Disease and postural abnormalities.

NCT ID: NCT03696589 Active, not recruiting - Parkinson's Disease Clinical Trials

Feasibility and Acceptability of a Physical Activity Behavior Change Intervention for Parkinson's Disease

Start date: May 21, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to assess the feasibility, in regards to acceptability and implementation, of the Pre-Active PD intervention for increased high intensity goal-directed aerobic exercise engagement in people with early-stage Parkinson's disease (Hoehn and Yahr stage I & II). In addition, the study aims to explore the effect estimates of the Pre-Active PD intervention on self-efficacy, motivation, stage of behavior change, and physical activity levels in people with early stage Parkinson's disease.

NCT ID: NCT03589872 Active, not recruiting - Parkinson Disease Clinical Trials

The Fine Motor Dexterity Under Dual Task in Parkinson's Disease

Start date: May 8, 2018
Study type: Observational

This study was planned to investigate the contribution of dual task interference on dexterity related ADL disability in patients with Parkinson's disease. We hypothesised that the dual task interference is an indicator of dexterity related ADL difficulties.

NCT ID: NCT03580096 Active, not recruiting - Parkinson Disease Clinical Trials

Core Stability and Parkinson Disease

Start date: January 8, 2018
Phase: N/A
Study type: Interventional

Patients with Parkinson's Disease frequently present impaired postural control that leads to loss of stability and increased risk of falls.Core system, includes passive structures of the thoracolumbar spine and pelvis that work as a unit to stabilize the body and spine against forces generated from distal body segments as well as forces generated from expected or unexpected perturbations.The objective of this study was to evaluate the effects of an intervention based on core stability in patients with Parkinson's Disease.

NCT ID: NCT03566589 Active, not recruiting - Parkinson Disease Clinical Trials

Effects of PS128 on Parkinsonian Symptoms

Start date: July 2, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to examine the short term effects (12 Weeks) of Lactobacillus plantarum PS128 (PS128) on Parkinson's disease (PD) symptoms.

NCT ID: NCT03555695 Active, not recruiting - Parkinson Disease Clinical Trials

Kick Out Parkinson's Disease

Start date: June 18, 2018
Phase: N/A
Study type: Interventional

The benefits of exercise for general health and wellbeing in older adults are well-established. Balance exercises such as tai chi and yoga, along with resistance training, can improve or maintain physical function in older adults and enhance muscle strength. Furthermore, aerobic activity is critical for maintaining and improving cardiovascular and functional health. Noncontact boxing has recently seen a surge in popularity among individuals with Parkinson's Disease (PD), with components of both aerobic and balance exercise. While participants anecdotally note improvements in stress and physical function, this has only been minimally studied. However, drawing on this experience and the combined aerobic, balance, and mindfulness practices that comprise karate, we hypothesize that participation in structured karate programs may offer similar or greater benefits. Specifically, the aim of this study is to test whether and to what degree a community-based karate class tailored for individuals with early- to middle-stage Parkinson's Disease (PD) 1) is feasible; and 2) improves objective and patient-reported outcomes.