Ischemic Cerebrovascular Accident Clinical Trial
— NEUTROSURGERYOfficial title:
Immuno-inflammation in the Acute Phase of an Ischaemic Cerebral Accident Managed by Decompressive Hemicraniectomy: a Case-control Study
The objective of the NEUTROSURGERY study is to describe the local and locoregional immuno-inflammatory activity in patients suffering from malignant sylvian ischaemic cerebral accident and treated with decompressive hemicraniectomy compared to a control population of patients to be operated on in neurosurgery for another neurosurgical pathology.
| Status | Not yet recruiting |
| Enrollment | 90 |
| Est. completion date | March 15, 2026 |
| Est. primary completion date | October 15, 2025 |
| Accepts healthy volunteers | |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | Inclusion Criteria Patients: - Collegial indication given by a neurologist, a neuroreanimator and a neurosurgeon for HD in the context of a malignant sylvian AIC. Inclusion Criteria Control: - For neurosurgical operations in which cranial, meningeal, vascular (branch of the middle meningeal artery) or cerebral bone tissue is not preserved during the surgical approach. Non-inclusion Criteria Patients: - HD carried out in a context of acute cerebral haemorrhage - Pre-existing neurological disability: modified Rankin score > 2 - Patient benefiting from a legal protection measure Non-inclusion Criteria Controls: - Patient to be operated on for an acute vascular condition: meningeal haemorrhage, subdural or extradural haemorrhage, intra parenchymal haemorrhage. - Patient operated on for an osteomeningeal pathology present at the approach site. - Patient operated on for an infectious cranial or neuro-meningeal pathology. - Patient to be operated on as a result of an intracranial traumatic condition |
| Country | Name | City | State |
|---|---|---|---|
| n/a | |||
| Lead Sponsor | Collaborator |
|---|---|
| Fondation Ophtalmologique Adolphe de Rothschild |
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | neutrophil polynuclear cells levels | Day 0 |
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02002390 -
Efficacy and Safety of FTY720 for Acute Stroke
|
Phase 2 | |
| Completed |
NCT02523261 -
Interest of Direct Aspiration First Pass Technique (ADAPT) for Thrombectomy Revascularisation of Large Vessel Occlusion in Acute Ischaemic Stroke
|
N/A | |
| Withdrawn |
NCT01985100 -
The Use of Hyperbaric Oxygen to Increase the Blood Supply in the Injured, But Still Alive Tissue, Around an Old Stroke
|
N/A | |
| Completed |
NCT01934374 -
Long-Term Effects of Task-Oriented Lower Extremity Strengthening Training
|
N/A | |
| Completed |
NCT02466893 -
COMPASS Trial: a Direct Aspiration First Pass Technique
|
N/A | |
| Completed |
NCT02452216 -
Using Ferumoxytol-Enhanced MRI to Measure Inflammation in Patients With Brain Tumors or Other Conditions of the CNS
|
Early Phase 1 | |
| Completed |
NCT02776540 -
Clopidogrel for Acute Ischaemia of Recent Onset
|
Phase 4 | |
| Not yet recruiting |
NCT04205578 -
NBP in Patients With Moyamoya Disease of High Risk for Ischemic Cerebrovascular Events
|
Phase 3 | |
| Recruiting |
NCT02900521 -
Population-based Brest Stroke Registry
|
||
| Not yet recruiting |
NCT02347358 -
Mechanical Opening Device Implantation Following Intravenous r-tPA for Recanalization in Acute Ischemic Stroke
|
Phase 2 | |
| Recruiting |
NCT03570060 -
Stepwise Screening for Silent Atrial Fibrillation After Stroke
|