Obesity Clinical Trial
To determine the association between ischemic heart disease incidence and anthropometric indices of body-fat distribution.
BACKGROUND:
Previous studies have demonstrated that abdominal obesity can be predictive of ischemic
heart disease. These prospective cohort studies employed simple indices of body-fat
distribution such as waist-to-hip circumference ratio or subscapular skinfold. Their similar
results suggested that increased abdominal obesity conferred a two-fold increased risk of
ischemic heart disease among middle-aged men. The two proposed studies permitted testing of
alternative fat-distribution indices which might be stronger risk factors for ischemic heart
disease incidence than the waist-to-hip-ratio or the subscapular skinfold.
DESIGN NARRATIVE:
Two parallel case-control studies were conducted. In both studies, subjects were measured
for girth, skinfold, abdominal sagittal diameter, height, and weight. Analyses for both
protocols considered men and women separately. Possible confounders of the association
between fat-distribution indices and ischemic heart disease were considered and if required,
adjusted for in multivariate analyses. Possible confounders included race, age, tobacco use,
alcohol use, diabetes, social class, hypertension, cholesterol levels, and physical activity
levels.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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