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NCT03308539 Clinical Trial

Prediction of Coronary Artery Disease Severity by Epicardial Adipose Tissue Thickness

Myocardial Infarction Clinical Trial

Official title:
Predictive Value of Epicardial Fat Thickness for Disease Severity in Coronary Artery Disease Patients

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03308539
Other study ID # epicardial adipose tissue
Secondary ID
Status Recruiting
Phase N/A
First received October 6, 2017
Last updated October 11, 2017
Start date November 1, 2017
Est. completion date September 1, 2018

Study information
Verified date October 2017
Source Assiut University
Contact jacqueline george, master
Phone 01275502685
Email jacquelinegeorge@yahoo.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

is to test the hypotheses that epicardial adipose tissue can be a marker of severity of coronary artery disease in myocardial infarction patients

Description:

epicardial adipose tissue is defined as the adipose tissue between the visceral pericardium and the outer margin of the myocardium which can be considered an endocrine organ that secretes pro-inflammatory and anti-inflammatory cytokines and chemokines including adiponectin.as investigators know, inflammatory response is an important factor in the coronary atherogenesis. Therefore,epicardial adipose tissue is likely to be connected with the severity of coronary artery disease.Recent studies showed that the thickness of the epicardial adipose tissue in patients with coronary artery disease was greater than that with normal coronary arteries.

epicardial adipose tissue will be assessed using transthoracic echocardiography and cardiac magnetic resonance which allows for an accurate volumetric quantification of epicardial fat.

Recruitment information / eligibility
Status Recruiting
Enrollment 200
Est. completion date September 1, 2018
Est. primary completion date December 1, 2017
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group N/A to 90 Years
Eligibility Inclusion Criteria

1. Normal thoracic shape

2. Sinus rhythm

3. without severe respiratory diseases

Exclusion Criteria:

1. contraindication for cardiac magnetic resonance.

2. Patients who previously underwent coronary artery bypass grafting or percutaneous coronary angiography prior to admission

3. history of chronic kidney disease with glomerular filtration rate <30 mL/min

4. pericardial and/or pleural effusion.

Study Design

Related Conditions & MeSH terms

Intervention

Radiation:
• echocardiography and cardiac magnetic resonance
transthoracic echocardiography and magnetic resonance imaging of the heart

Locations
Country Name City State
Egypt Jacqueline George Assiut Single

Sponsors (1)
Lead Sponsor Collaborator
Osama Fekry

Country where clinical trial is conducted

Egypt, 

References & Publications (1)

Desferrioxamine and transfusional iron overload. Lancet. 1978 Mar 4;1(8062):479-80. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary measurement of epicardial adipose tissue as marker of severity of coronary artery disease in myocardial infarction patients. epicardial adipose tissue measurement using transthoracic echocardiography and cardiac magnetic resonance one year
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