| Eligibility |
Inclusion Criteria:
1. Subject is a healthy volunteer who is able to understand the requirements of the
study, provide written informed consent, abide by the study restrictions, and agree to
return for the required assessments.
2. Subject must be 18 to 55 (inclusive) years of age, at the time of signing the informed
consent.
3. Subject has a BMI between 18.5 kg/m2 and 30 kg/m2 (inclusive), with a minimum body
weight of 50 kg.
4. Subject is male or female.
5. Females are eligible to participate if not pregnant, not breastfeeding, and at least
one of the following conditions applies:
- Surgically sterile or at least 2 years menopausal, confirmed by
follicle-stimulating hormone (FSH) at Screening, or,
- If women of childbearing potential (WOCBP), subject must use an acceptable method
of birth control from date of Screening to at least 30 days after the last dose
of study intervention and must have a documented negative blood or urine
pregnancy test within 24 hours prior to dosing (SAD cohort) or within 48 hours
prior to dosing (MAD cohorts). If reported sterile or postmenopausal, will be
confirmed by FSH.
6. Male subject must meet one of the following:
- Surgically sterile
- If not surgically sterile, then use of an acceptable form of contraception as
detailed in Appendix 4 from the time of randomization through 28 days following
the last dose of study intervention. Male subjects or male partners of female
subjects are recommended to not donate sperm from Screening (Visit 1) until 28
calendar days after the last dose of study intervention. Male subjects are
strongly advised to inform female partners of the need for them to use acceptable
birth control methods during this time period.
7. Clinical laboratory values <2 times the upper limit of normal or deemed not clinically
significant by the Investigator at Screening and Admission Day.
Exclusion Criteria:
1. Type I or Type II diabetes mellitus.
2. Malignancy in the last 5 years, with the exception of nonmetastatic basal cell or
squamous cell carcinoma of the skin or localized carcinoma in situ of the cervix.
3. History of allergy or sensitivity, or intolerance to N-methyl-D-aspartate (NMDA)
receptor ligands including ketamine, dextromethorphan, memantine, methadone,
dextropropoxyphene, or ketobemidone.
4. Psychiatric disease including major depressive disorder, bipolar disorder, anxiety, or
schizophrenia, or other medical condition that, in the opinion of the Investigator,
would interfere with the evaluation of study intervention safety.
5. Any personal or family history of seizure (including febrile seizures) or diagnosis of
epilepsy or episode of unexplained loss of consciousness.
6. Any history of neurological or other medical conditions which in the opinion of the
Investigator has the potential to reduce seizure threshold, e.g., history of head
concussion, traumatic brain injury, taking any medications that may reduce seizure
threshold, developmental abnormalities in the brain, or metabolic causes, including
electrolyte abnormalities such as hyponatremia.
7. Subject has a history of excessive bleeding after invasive procedures or surgery or
known coagulation or platelet abnormality or has been on any blood thinner or
medication affecting platelet function, such as aspirin, nonsteroidal antiinflammatory
medications, corticosteroids (except topical) or warfarin within the 7 days prior to
enrollment or has known allergy to any anesthetic agent that may be used for the
lumbar catheterization.
8. Subject has a history of infection that required IV antibiotics within the 45 days or
oral antibiotics within 30 days prior to enrollment, and, at the time of clinic
admission, be febrile or have signs/symptoms consistent with an infection.
9. Subject has a history of or physical examination evidence of a lumbar spine
abnormality that may preclude placement of a spinal catheter, presence of intraspinal
shunt devices (e.g., ventriculoperitoneal shunt), or history of elevated intracranial
pressure, normal pressure hydrocephalus, or other neurological condition that in the
opinion of the Investigator precludes safe study participation. A lumbar X-ray that
excludes spine abnormalities must have been taken within the past 12 months and made
available or the subject must agree to have one taken as part of the qualification.
10. In the opinion of the Investigator, the Safety Monitor, or the Sponsor Study Monitor,
has a history of severe renal or hepatic impairment, severe active hepatic disease, or
other clinically significant medical condition that may preclude safe study
participation.
11. Subject who has clinical signs and symptoms consistent with severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2); e.g., fever, dry cough, dyspnea, sore throat,
fatigue, or positive SARS-CoV-2 test result within 14 days prior to the Screening
Visit or at admission.
12. Subject who had a severe course of SARS-CoV-2 (extracorporeal membrane oxygenation,
mechanically ventilated).
13. Currently taking prescription or over-the-counter medications including herbal
therapies, within 14 days of enrollment into the study.
14. Received another investigational drug or device within 30 days or 5 half-lives,
whichever is longer prior to enrollment in this study (defined as the time of
admission; Day -2 for MAD and Day -1 for SAD).
15. Previously randomized in this study.
16. Has a positive test for hepatitis B surface antigen, hepatitis B core antibody,
hepatitis C antibody, or human immunodeficiency virus (HIV) at Screening or has been
previously treated for hepatitis B, hepatitis C, or HIV infection.
17. For Cohorts 2-5, evidence of hearing loss that cannot be compensated for in the event
related potential (ERP) tests, assessed by audiologic examination.
18. Evidence of alcohol abuse, defined as regular consumption of alcohol within 6 months
prior to screening defined as > 7 drinks/week for females and > 14 drinks/week for
males where 1 drink = 5 ounces (150 mL) of wine or 12 ounces (360 mL) of beer or 1.5
ounces (45 mL) of hard liquor. Use of illicit substances and recreational drug use
(such as marijuana) within 3 months prior to the Screening Visit is also prohibited.
19. Current abuse of illicit substances, using the Diagnostic and Statistical Manual V
definition of substance use disorder.
20. Has a positive urine screen for drugs of abuse (see Table 10 1) at Screening and
admission day (Day -2 for MAD and Day -1 for SAD).
21. Currently pregnant, planning to become pregnant during the course of the study, or
nursing mother.
22. At Screening, if the Columbia-Suicide Severity Rating Scale (C-SSRS) responses ("yes"
answers to item 4 or 5) indicate that the subject may have experienced suicidal
ideation associated with actual intent or plan within 12 months of Screening, may have
had a history of suicidal behavior within the past 10 years, or had any lifetime
history of recurrent suicidal behavior, the subject will be excluded from
participation in the study.
23. Previous cerebrospinal fluid (CSF) collection within 30 days prior to admission to the
clinical research unit.
24. Impaired function (glomerular filtration rate <60 mL/min) by the chronic kidney
disease-Epidemiological Collaboration (CKD-EPI Creatinine) calculation method. Can be
repeated once during Screening and once during admission.
25. Elevated systolic blood pressure (>140 mmHg) or diastolic blood pressure (>90 mmHg)
and/or increased corrected QT interval (QTc) (>450 msec for men or >470 msec for
women) or additional risk factors for Torsades de Pointes including heart failure,
hypokalemia, or family history of Long QT Syndrome at Screening or Admission Day. Can
be repeated once during Screening and once during admission.
26. Has donated blood (=500 mL) or blood products within 6 weeks (42 days) prior to
admission.
27. Subject is deaf or has hearing loss of more than 25 decibels (dB) in one or both ears.
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