Chronotherapy Randomized Controlled Trial

Major Depressive Disorder Clinical Trial

Official title:

Adjunct Total Sleep Deprivation, Sleep Phase Advance, and White Light Therapy Vs. Partial Sleep Deprivation, Sleep Phase Delay, and Amber Light Therapy as Adjunctive Treatments in Acutely Suicidal and Depressed Inpatients.

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT02176824
• Other study ID #: Chronotherapy RCT
• Status: Terminated
• Phase: N/A
• Start date: June 1, 2014
• Est. completion date: April 7, 2016

Study information

• Verified date: May 2019
• Source: Medical University of South Carolina
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Chronotherapy is a term that describes therapeutic alterations of sleep wake cycles. Different variations of sleep deprivation, set sleep wake schedules, and types of light therapy have demonstrated efficacy in rapidly treating depression, and suicidal thinking. This study seeks to explore the effect of two different chronotherapuetic protocols on acutely depressed and suicidal inpatients admitted to the Medical University of South Carolina

Description:

There is a consistently reported, rapid antidepressant response to a single night of total sleep deprivation in both unipolar, and bipolar depression. The clinical utility of this technique has been limited however, because responders have typically relapsed rapidly following recovery sleep. The addition of pharmacotherapy, sleep phase advance (a shift to an earlier sleep schedule with normalization over three days), and bright light therapy to sleep deprivation have each demonstrated efficacy in preventing relapse into depression. Combined total sleep deprivation, sleep phase advance, and bright light therapy, dubbed Triple Chronotherapy along with concomitant pharmacotherapy has demonstrated a rapid improvement in depressive symptoms that has remained durable for as long as 9 weeks post intervention. If the early, encouraging results of Triple Chronotherapy hold up to further study, the technique represents a near ideal inpatient treatment, as it is inexpensive, relatively easy to carry out, and has minimal side effects.

Despite encouraging early results, only one published report has attempted to use triple chronotherapy in suicidal patients, and in that trial only bipolar depressed patients were included, and one single variation of chronotherapy was tested (Three nights of sleep deprivation every other night with three light therapy sessions, combined with lithium). The lack of data in acutely suicidal patients significantly limits the utility of this intervention in the United States, where few non-suicidal patients are admitted. Published trials to this point have also excluded those with comorbid illness, which also limits the clinical usefulness of this intervention to a minority of patients. Furthermore there are sparse randomized adequately controlled trials, and still limited durability data on the technique.

We recently explored the tolerability and feasibility of the technique on acutely depressed and suicidal inpatients admitted to our inpatient unit with encouraging results. We subsequently propose to further explore the utility of this technique by piloting its effect compared to an active sham condition to determine if further study is indicated. Should further study be warranted, we hope to use the collected pilot data to determine the necessary number of participants to detect an effect.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 13
• Est. completion date: April 7, 2016
• Est. primary completion date: April 7, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

• A current episode of non-psychotic major depression

• Currently hospitalized

• Age greater than 18

• If bipolar illness, must not be a mixed state, and must be on a therapeutic dose of a mood stabilizer

Exclusion Criteria:

• Urine drug screen positive for cocaine, or current alcohol/dependence that requires detox

• current psychosis

• Panic Disorder

• Severe Borderline Personality Disorder

• A history of seizures, uncontrolled severe headaches, stroke, or other neurologic illness that produces either gait abnormalities or lowered seizure threshold

• Medical illness that would make wake therapy intolerable

• Cataracts, glaucoma, or other intrinsic eye condition

• Currently taking light sensitizing medications

• Current pregnancy

• Mental retardation or dementia

• Untreated sleep disorder such as Obstructive Sleep Apnea(OSA), narcolepsy, or periodic limb movement disorder(PLMD) that results in excessive sleepiness

• Currently receiving electroconvulsive therapy (ECT)

Related Conditions & MeSH terms

• Bipolar Depression
• Bipolar Disorder
• Depression
• Depressive Disorder
• Depressive Disorder, Major
• Major Depressive Disorder
• Sleep Deprivation
• Suicidal Ideation

Intervention

Behavioral:
• Total Sleep deprivation, Sleep Phase Advance, and Bright Light Therapy
Sleep deprivation, Sleep phase advance, and Bright light therapy
• Partial Sleep deprivation, Sleep Phase Delay, and Low amber light.

Other:
• Treatment as usual

Locations

Country	Name	City	State
United States	Medical University of South Carolina	Charleston	South Carolina

Sponsors (1)

Lead Sponsor	Collaborator
Medical University of South Carolina

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Hamilton Depression Rating Scale	Change in scores from Pre and Post Hamilton Depression scores	Day prior to total sleep deprivation, and then again over the next 4 consecutive days. There will then be a continuation phase where data will be collected at one week, two weeks, 4 weeks, and 8 weeks.
Primary	Columbia Suicide Severity Rating Scale	Change in score of Columbia Suicide Severity Rating Scale	Day prior to total sleep deprivation, and then again over the next 4 consecutive days. There will then be a continuation phase where data will be collected at one week, two weeks, 4 weeks, and 8 weeks.