Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse

Major Depressive Disorder Clinical Trial

Official title:

Integrated CBT for Substance Use and Depressive Disorders

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00108407
• Other study ID #: MHBS-041-99Sa
• Status: Completed
• Phase: N/A
• First received: April 14, 2005
• Last updated: March 4, 2009
• Start date: October 2004

Study information

• Verified date: March 2009
• Source: VA Office of Research and Development
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine whether Integrated Cognitive Behavioral Therapy or Twelve Step Facilitation Therapy is most effective for treatment of dually diagnosed veterans with depressive and substance use disorders.

Description:

Depression is the most frequent co-occuring mental health disorder among adults with substance use disorders, and such comorbidity is often associated with poorer treatment outcomes. Although there is an urgent need for effective treatments specific for dual-diagnosis adults, few studies have been conducted to address this need.

Comparison: This study will compare substance use and depression symptoms of individuals in two different psychotherapy groups: Integrated Cognitive Behavioral Therapy and Twelve Step Facilitation Therapy. Symptoms and substance use will be compared during the active treatment phase (24 weeks) and for one year following the end of the active treatment.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 0
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Individuals diagnosed with one or more substance use disorders (alcohol, cannabis, and or stimulant abuse/dependence) and an independent co-occurring depressive disorder (major depression or dysthymia) will be included.

Exclusion Criteria:

• Individuals with substance induced mood disorders and individuals experiencing persistent psychotic symptoms.

• Those with life threatening or unstable medical illness, neurological disorders, or inability to read will be excluded.

• Individuals currently prescribed steroids, disulfiram, or long acting benzodiazepines will be excluded.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label

Related Conditions & MeSH terms

• Alcohol Abuse
• Cannabis Abuse
• Depression
• Depressive Disorder
• Depressive Disorder, Major
• Disease
• Major Depressive Disorder
• Substance-Related Disorders

Intervention

Behavioral:
• Integrated Cognitive Behavioral Therapy

• Twelve Step Facilitation Therapy

Locations

Country	Name	City	State
United States	VA San Diego Healthcare System, San Diego	San Diego	California

Sponsors (1)

Lead Sponsor	Collaborator
VA Office of Research and Development

Country where clinical trial is conducted

United States,