Ischemic Stroke Clinical Trial
Official title:
Alpha-linolenic Acid and the Risk of Atherosclerotic Cardiovascular Disease
Background: The plant-derived omega-3 fatty acid alpha-linolenic acid (ALA, 18:3-n-3) may
reduce the risk of atherosclerotic cardiovascular disease, including incident myocardial
infarction, ischemic stroke and peripheral artery disease. However, the results of previous
studies have been inconsistent.
Objectives: To investigate the associations between dietary intake of ALA, adipose tissue
content of ALA, and the risk of the major atherosclerotic cardiovascular diseases incident
myocardial infarction, ischemic stroke and subtypes, and peripheral artery disease.
Methods: This project will be based on data from the Danish cohort study Diet, Cancer and
Health which consisted of 57,053 men and women at recruitment between 1993 and 1997. Dietary
intake of ALA will be assessed using a validated semiquantitative food-frequency
questionnaire and adipose tissue content will be determined with the use of gas
chromatography analyses of adipose tissue biopsies collected at baseline. Also, detailed
information on lifestyle factors, medical history and anthropometri was collected at
baseline.
Incident cases have been identified through national registries and the diagnoses have
previously been validated.
Analyses of dietary intake of ALA will be analysed using a traditional cohort design, whereas
analyses on adipose tissue content of ALA will be analysed based on a case-cohort design.
Hazard ratioes with 95% confidence intervals will be used to describe the associations
between the exposure variables and the outcome variables of interest.
n/a
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