Coronary Arteriosclerosis Clinical Trial
Official title:
Paracetamol and Endothelial Function in Patients With Stable Coronary Artery Disease
The purpose of this study is to determine the effect of orally given paracetamol on the vascular function and on 24-hour blood pressure in patients with coronary artery disease
Patients with chronic pain diseases (e.g. osteoarthritis) are dependent on effective
medication. NSAIDs are very effective in lowering pain in these patients. Recently there has
aroused major concern with regard to cardiovascular side effects and safety, especially in
selective cyclooxygenase-2 inhibitors (coxibs) but also in "regular" NSAIDs.
At the moment, there is a big confusion, whether these drugs still should be used, especially
in patients with known coronary artery disease. Physicians now try to switch to high dose
paracetamol, despite the weaker efficacy in pain relieve, because this drug is considered
generally as not harmful.
As there is very few information on the cardiovascular effect of this drug, we plan to
perform this study and investigate the impact of paracetamol on endothelial function, an
important cardiovascular surrogate marker, on inflammatory markers and on oxidative stress in
patients with coronary artery disease on top of standard medication, including aspirin
;
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