Cardiovascular Diseases Clinical Trial
To quantify the role of dietary factors in the etiology of coronary heart disease by pooling data from 10 major prospective studies on diet and coronary heart disease.
DESIGN NARRATIVE:
Specific hypotheses tested included an adverse effect of saturated fat and carotenoids
(alpha-carotene, lutein, and lycopene), flavonoids, folic acid, and vitamin B6. Plausible
biological interactions between nutrients, such as fatty acids of the n-6 and n-3 series
were also explored. Each participating center sent data on tape to the coordinating unit at
the Department of Nutrition, Harvard School of Public Health. The relations of dietary
factors and coronary heart disease were first estimated within each study and compared for
consistency. Data were then combined to obtain the best overall estimates, taking into
account the validity of dietary data collected at each center. Members from study centers
met annually to discuss the interpretation of findings. Over 6,000 cases of myocardial
infarction or coronary death were anticipated, which should have provided excellent
precision in measuring associations, and allowed the comparison of extreme intakes that were
poorly represented in individual studies.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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