Accelerated Intermittent Theta-Burst Stimulation for Opiate Use Disorder

Status Not yet recruiting

Clinical Trial Summary

This study aims to examine whether multiple spaced sessions of intermittent theta-burst transcranial magnetic stimulation (iTBS) induce anti-depressant responses and reduce opiate cravings in adults with opiate use disorder (OUD). Additionally, we hope to identify whether the effectiveness of iTBS is related to changes in functional connectivity between particular brain areas.

Clinical Trial Description

The proposed study aims to investigate the effectiveness of aiTBS applied to either the L-DLPFC or the ACC for reducing SI in individuals with OUD and identify neural functional connectivity changes underlying treatment response. 30 individuals with OUD who endorse suicidal ideation will be recruited. The accelerated iTBS treatment will involve 10 daily sessions of iTBS. Stimulation will be delivered to either the ACC or the L-DLPFC for 5 consecutive days. Suicidal ideation, depressive symptoms and opiate misuse will be measured before and after the 5-day stimulation course. Functional magnetic resonance imaging (fMRI) scans will also be carried out before and after stimulation to examine aiTBS-induced changes in neural functional connectivity. Changes in suicidal ideation, depressive symptoms and opiate misuse will be measured using both clinician-rated and self-report assessments. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03804619
Study type	Interventional
Source	Stanford University
Contact	Brendan Wong
Phone	650-374-0907
Email	bwong14@stanford.edu
Status	Not yet recruiting
Phase	N/A
Start date	June 1, 2024
Completion date	December 1, 2025

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