Depression Clinical Trial
Official title:
Anxiety and Depression Disorder in Patient Treated With rTPA for Mangment of Acute Ischemic Stroke
In fact theWorld Health Organization estimates that 2-3% in general populations of countries across the world tend to be affected by severe mental disorders (1) Thrombolytic therapy seems to be of great importance in achieving better quality of life in ischemic stroke patients who respond to this therapy(rTPA).
There is a substantial body of evidenc suggesting a strong relation between neurotrophic
factors and depression and anxiety pathogenesis (2,8) Brain-derived neurotrophic factor
(BDNF), a member of the neurotrophic family known to regulate neuronal plasticity and
survival , may play an important role in the pathophysiology of depression and anxiety (3,9).
Different studies indicated patients who were exposed to traumatic events have anxiety
comorbidity and lower levels of serum BDNF compared to those without a history of traumatic
events (4) .
BDNF has an antidepressant and anxiolytic effect which suggest that BDNF is implicated in the
regulation of anxiety-related behaviors. which leads to a valine-to-methionine change in the
proBDNF protein, was associated with lower activity-dependent secretion of BDNF (5)and has
been implicated with increased susceptibility to neuropsychiatric disorders including
depression, anxiety-related dysfunction, and bipolar disorder , all these studies suggest
that BDNF is likely to be an important etiological factor in memory, depression and anxiety
disorders (6,10).
BDNF arises from a precursor, proBDNF, which is cleaved to produce the mature protein through
the tissue plasminogen activator (tPA) pathway, and represents one mechanism that can
regulate the action of BDNFarises from a precursor, proBDNF, which is cleaved to produce the
mature protein through the tissue plasminogen activator (tPA) pathway, and represents one
mechanism that can regulate the action of BDNF (7).
The purpose of this study is to examine the quality of life after stroke of patients treated
with thrombolysis .
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