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NCT ID: NCT06188598 Recruiting - Obesity Clinical Trials

Time-restricted Eating in Peri- and Postmenopausal Women

Start date: December 21, 2022
Phase: N/A
Study type: Interventional

The overall objective of the study is to examine the effect of an 8-hour time-restricted eating intervention on lipid levels and body composition in peri- and recently postmenopausal women with untreated dyslipidemia.

NCT ID: NCT06188559 Recruiting - Breast Cancer Clinical Trials

A Study of BB-1701 in Previously Treated Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive or HER2-low Unresectable or Metastatic Breast Cancer

Start date: April 10, 2024
Phase: Phase 2
Study type: Interventional

The primary purpose of the Dose Optimization (Part 1) of this study is to assess the safety and tolerability of BB-1701 and to determine the recommended dose (RD) of BB-1701 for Dose Expansion (Part 2). The primary purpose of Dose Expansion (Part 2) is to assess the antitumor activity of BB-1701 at RD in the selected population(s) of breast cancer (BC).

NCT ID: NCT06188520 Recruiting - Clinical trials for ER+ HER2- Advanced Breast Cancer

A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors

CYCAD-1
Start date: December 5, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

This study is designed to evaluate AZD8421 alone and in combination with selected targeted anti-cancer drugs in patients with ER+HER2- advanced breast cancer, and patients with metastatic high-grade serious ovarian cancer.

NCT ID: NCT06188364 Recruiting - Clinical trials for Traumatic Brain Injury

Improving Traumatic Brain Injury Rehab Care With Comm Health Services: a Research Project Within the TBI Model System

Start date: April 26, 2024
Phase: Early Phase 1
Study type: Interventional

TBI rehabilitation care transitions refer to the processes of preparing patients, families, and community-based healthcare providers for the patient's passage from inpatient rehabilitation to the home and community or to another level of care. Persons with TBI have heterogenous neurological impairment (cognitive and behavioral foremost, along with motor, sensory, and balance), that limits their functional independence and participation, and increases their risk for secondary medical conditions, injuries, rehospitalizations and early mortality

NCT ID: NCT06188325 Completed - Gaucher's Disease Clinical Trials

A Study to Evaluate Pharmacokinetic Parameters of Eliglustat in Healthy Volunteers Who Are CYP2D6 Extensive or Poor Metabolizers

Start date: January 1, 2018
Phase: Phase 1
Study type: Interventional

The primary objective of the study is to evaluate dose proportionality and pharmacokinetics for three different dose levels of eliglustat after single and repeated administration.

NCT ID: NCT06188221 Completed - Clinical trials for Carpal Tunnel Syndrome

Does Adding Lidocaine to Corticosteroid Injections Reduce Pain Intensity in Hand Surgery

Start date: February 1, 2020
Phase: N/A
Study type: Interventional

The purpose of this study was to determine whether adding Lidocaine to Corticosteroid injections reduce pain intensity in hand surgery.

NCT ID: NCT06188208 Recruiting - Clinical trials for Advanced Solid Tumors

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-130850 in Participants With Advanced Solid and Hematologic Tumors

Start date: January 5, 2024
Phase: Phase 1
Study type: Interventional

A FIH study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of VVD-130850, as single agent and in combination with checkpoint inhibition, in participants with advanced solid and hematologic tumors.

NCT ID: NCT06187857 Completed - Neurorehabilitation Clinical Trials

A Virtually Delivered Memory Rehabilitation Protocol in Older Adults

EONMem_OA
Start date: December 1, 2020
Phase: N/A
Study type: Interventional

The investigators conducted a feasibility study of a virtually-delivered adaptation of an ecologically oriented neurorehabilitation of memory (EON-Mem) in improving memory for healthy older adults. The primary purposes of this study included determining the feasibility of conducting EON-Mem virtually with older adults and whether a randomized control trial using EON-Mem in older adults is of value.

NCT ID: NCT06187805 Enrolling by invitation - Dental Implants Clinical Trials

Retrospective Case Series - OSSIX Volumax Collagen Xenograft Scaffolding

Start date: November 16, 2023
Phase:
Study type: Observational

This study is designed as a retrospective, single center study. Up to 15 participants who had a transcrestal sinus elevation and implant placement using autogenous bone supporting an OSSIX Volumax collagen xenograft scaffolding will be enrolled. The study will include data collection from medical records and data collected at a follow up visit between January 2019 and March 2023.

NCT ID: NCT06187701 Not yet recruiting - Clinical trials for Substance Use Disorders

Co-Active Therapeutic Theatre (Co-ATT) for Dual-Diagnosis Patients

Co-ATT
Start date: September 2024
Phase: N/A
Study type: Interventional

Drama Therapy involves of the use of theatrical techniques (such as script development, acting exercises, improvisation, etc.) to help treat patients' mental illness and improve their functioning and overall sense of wellbeing. This study will evaluate the effectiveness of a specific version of drama therapy for the treatment of patients suffering from both mental illness (such as depression, bipolar disorder, schizophrenia, etc.) and one or more substance use disorders. The study will also assess participants feelings and thoughts about the drama therapy intervention (such as whether or not they enjoyed it and if/how they found it helpful). The drama therapy intervention will consist of one group drama therapy session per week, for a total of twelve weeks (i.e., total twelve sessions) followed by a single performance (with composition of the audience determined by unanimous agreement of the participants) of the dramatic work (script) produced by the participants during the course of the drama therapy intervention.