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NCT ID: NCT03625414 Completed - Clinical trials for Chronic Periodontitis

Tissue Alterations in Aggressive and Chronic Periodontitis

Start date: February 1, 2017
Phase:
Study type: Observational

Present study intended to compare diseased and healthy sites in chronic and aggressive periodontitis with healthy individuals. We suggest that even unaffected healthy sites of both chronic and aggressive periodontitis patients exhibit subclinic inflammation and tissue destruction with decreased fibroblast cell counts and increased inflammatory cell counts. We also suggest that a possible mechanism which might play a role in the disease progression might occur via a disbalance between matrix metallo proteinases and their inhibitors, and increased hypoxia in diseased sites.

NCT ID: NCT03625063 Recruiting - Clinical trials for Hematopoietic Stem Cell Transplantation

Effects of Pulmonary Rehabilitation in Hematopoietic Stem Cell Transplantation Recipients

Start date: February 1, 2018
Phase: N/A
Study type: Interventional

Stem cell transplantation is a process in which stem cells are harvested from either a patient's or donor's bone morrow or peripheral blood for intravenous infusion. Hematopoietic stem cell transplantation is a treatment with a high curative potential that may benefit a great number of patients with hematological, oncological, immunologic and hereditary diseases. In contrast, there are significant risks of chronic and acute complications due to conditioning regimens and immunosuppression, toxicity infections, graft versus host disease (GVHD) and inactivity including being bedridden. Patients undergoing hematopoietic stem cell transplantation are exposed to risk factors due to chemotherapy, whole body radiation, high dose corticosteroids, treatment-related inactivity, transplantation and GVHD-related muscle damage. Direct toxicity of the cardiovascular and musculoskeletal system (left ventricular dysfunction, pulmonary fibrosis) in relation to hematopoietic stem cell transplantation and secondary indirect physiological consequences of treatment such as exercise intolerance, sarcopenia are seen. In literature, there are few studies showing that aerobic exercise and resistance training applied during and after the transplantation process has positive effects on muscle strength and endurance, fatigue, functional performance, quality of life and physical activity. It has been shown in the literature that inspiratory muscle training in allogeneic hematopoietic stem cell transplant recipients increases functional exercise capacity, inspiratory and expiratory muscle strength, and reduces effort dyspnea perception, but the effects of inspiratory muscle training during transplantation have not been investigated. There are no studies showing long-term follow-up of comprehensive cardiopulmonary rehabilitation program during hematopoietic stem cell transplantation and which of these outcome measures are survival effect. Therefore, the investigators aimed to investigate the effect of cardiopulmonary rehabilitation on hematopoietic stem cell transplantation in terms of exercise capacity, respiratory and peripheral muscle strength, respiratory muscle endurance, respiratory function, physical activity level, fatigue, depression and quality of life effects and the effect of these outcome measures on survival.

NCT ID: NCT03623399 Recruiting - Postoperative Pain Clinical Trials

Laparoscopic Gas Pressure and Postoperative Pain Score

Start date: August 7, 2018
Phase: N/A
Study type: Interventional

Aim of the study is to determine the effect of different laparoscopic intraoperative intraabdominal gas (CO2) pressures on the extent of postoperative pain scores.

NCT ID: NCT03623230 Recruiting - Pain, Postoperative Clinical Trials

Concentration Effect of Local Anesthetics on Femoral Nerve Block Efficiency

Start date: February 15, 2018
Phase: Phase 4
Study type: Interventional

US-guided femoral nerve block is used effectively in post-operative pain management in the surgical treatment of the lower extremity. However, the volume and concentration of the local anesthetic drug to be administered remains controversial. In this prospective, randomized, double-blinded study, patients who underwent unilateral primary total knee arthroplasty and successfully performed spinal anesthesia with standard method and dosage, will be selected for US-guided femoral nerve block after the operation. Patients will be divided into three groups with simple randomization. The First group will be determined as the control group (GCont) and only dressing will be applied to the patients. For second group(G125), 0,125% 20 ml local anesthetic and for the third group (G25), 0,25% 10 ml local anesthetic will be administered to the femoral nerve without changing the drug dose (25 mg bupivacaine). Whether there is a difference between post-op analgesia durations, motor block formation, mobilization time and 90° flexion time between the groups will be investigated.

NCT ID: NCT03622593 Not yet recruiting - Clinical trials for Diabetic Macular Edema

A Study to Evaluate the Efficacy and Safety of RO6867461 in Participants With Diabetic Macular Edema

RHINE
Start date: September 21, 2018
Phase: Phase 3
Study type: Interventional

This study will evaluate the efficacy, safety, and pharmacokinetics of RO6867461 administered at 8-week intervals or as specified in the protocol following treatment initiation, compared with aflibercept once every 8 weeks (Q8W), in participants with diabetic macular edema (DME).

NCT ID: NCT03622580 Not yet recruiting - Clinical trials for Diabetic Macular Edema

A Study to Evaluate the Efficacy and Safety of RO6867461 in Participants With Diabetic Macular Edema (YOSEMITE)

Start date: September 22, 2018
Phase: Phase 3
Study type: Interventional

This study will evaluate the efficacy, safety, and pharmacokinetics of RO6867461 administered at 8-week intervals or as specified in the protocol following treatment initiation, compared with aflibercept once every 8 weeks (Q8W), in participants with diabetic macular edema (DME).

NCT ID: NCT03621917 Recruiting - Acute Stroke Clinical Trials

Evaluation of tPA Efficacy in Acute Stroke Patients With NIRS (Near-infrared Spectroscopy)

E-NESE
Start date: November 1, 2017
Phase:
Study type: Observational

Investigators aim to study efficiency of systemic thrombolytic therapy on acute ischemic stroke patients with near infrared spectroscopy.

NCT ID: NCT03621891 Completed - Clinical trials for Chronic Periodontitis

Alterations in Subgingival Microbiota and Hypoxia in Occlusal Trauma

Start date: May 1, 2016
Phase:
Study type: Observational

Present study suggests that excessive occlusal forces did not cause a significant change in hypoxia and vascular markers, however a slight alteration in subgingival microbiota was observed.

NCT ID: NCT03621345 Not yet recruiting - Postoperative Pain Clinical Trials

Bilateral Ultrasound-Guided Erector Spinae Plane Block For Postoperative Analgesia in Breast Reduction Surgery

Start date: August 15, 2018
Phase: N/A
Study type: Interventional

Erector spinae plane (ESP) block is a novel block developed by Forero to treat severe neuropathic pain and was firstly reported in 2016. Anatomical and radiological investigations in fresh cadavers indicate that its site of action is likely at the dorsal and ventral rami of the thoracic spinal nerves. The ESP block has a clear and simple sonoanatomy, it is easy to perform, not time consuming and generally well tolerated by the patients. So, the investigators believed that the ESP block may be an effective and safer alternative to paravertebral block, epidural analgesia and other myofascial thoracic wall blocks in breast surgery and designed a prospective, randomised, placebo-controlled trial for pain management.

NCT ID: NCT03621007 Not yet recruiting - Clinical trials for PCSK1 Deficiency Obesity

An Observational,Prospective Natural History Study of Early-Onset Extreme Obesity Due to Bi-Allelic Loss-of-Function Mutations in the POMC, PCSK1 or LEPR Genes

NHS
Start date: December 15, 2018
Phase:
Study type: Observational

This is an observational study. There are no protocol-defined visits, although patients are expected to have routine office visits approximately every 6 months. Upon signing of informed consent/assent and study enrollment, historical data will be abstracted from the patient's medical chart. The patient will then be observed prospectively for up to 5 years, with additional data collected from routine healthcare encounters and direct-to-patient questionnaires (where local laws allow), including laboratory tests, physical exam and patient reported outcomes/quality of life measures. Patients will be consented/assented to provide blood samples for biomarker assessments, DNA sequencing and archiving.