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NCT ID: NCT00856661 Terminated - Stroke Clinical Trials

Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke (DIAS-4)

Start date: April 2009
Phase: Phase 3
Study type: Interventional

The purpose of the study is to determine whether desmoteplase is effective and safe in the treatment of patients with acute ischaemic stroke when given within 3 to 9 hours from onset of stroke symptoms.

NCT ID: NCT00856544 Completed - Clinical trials for Arthritis, Rheumatoid

A Study Comparing 2 Doses Of CP-690,550 Vs. Placebo For The Treatment Of Rheumatoid Arthritis In Patients On Other Background Arthritis Medications

Start date: May 2009
Phase: Phase 3
Study type: Interventional

This Phase 3 study is intended to provide evidence that CP-690,550 dosed 5 mg BID and 10 mg BID is safe and effective when used in combination with a variety of traditional disease modifying antirheumatic drugs in adult patients with rheumatoid arthritis. It is intended to confirm the benefits of CP-690,550 in improving signs and symptoms and physical function that were observed in the Phase 2 rheumatoid arthritis studies.

NCT ID: NCT00856011 Completed - Clinical trials for Carpal Tunnel Syndrome

Nerve Morphology in Diabetic Patients

Start date: December 2003
Phase: N/A
Study type: Observational

The underlying basis of carpal tunnel syndrome and the basis of its increased incidence in diabetes are unknown. The aim of this study was to quantified pathology in an uncompressed nerve (posterior interosseous nerve in the forearm between diabetic and non-diabetic patients with CTS.

NCT ID: NCT00855166 Completed - Clinical trials for Type 2 Diabetes Mellitus

Evaluation of the Effect of Dapagliflozin in Combination With Metformin on Body Weight in Subjects With Type 2 Diabetes

Start date: February 2009
Phase: Phase 3
Study type: Interventional

This study is being carried out to see if dapagliflozin in addition to metformin decreases body weight and if so, how it compares with metformin alone.

NCT ID: NCT00853762 Terminated - Clinical trials for Relapsing Multiple Sclerosis

Atacicept in Multiple Sclerosis Extension Study, Phase II

ATAMS ext
Start date: February 2009
Phase: Phase 2
Study type: Interventional

This study, 28851, is a long-term follow-up study of subjects enrolled in ATAMS study 28063, the aim of which is to monitor the safety and tolerability of atacicept administered for up to 5 years to subjects with relapsing multiple sclerosis (RMS). This extension study consists of two parts. Part A will be double blind and Part B will be open label. During Part A subjects initially randomized to atacicept will continue to receive the atacicept dose to which they have been randomized in study 28063 (ATAMS) once a week sub cutaneously (under the skin). Subjects randomized to placebo in ATAMS will receive atacicept at 150 mg once a week sub cutaneously during Part A. Once the results of ATAMS are available and the atacicept dose with the best benefit / risk ratio has been identified, all subjects will be switched to this dose and will continue the extension study open-label (Part B). Throughout the study, subjects and investigators will remain blinded with respect to intial and part A treatment allocation/dose.

NCT ID: NCT00853658 Completed - Clinical trials for Chronic Heart Failure

Efficacy and Safety of Aliskiren and Aliskiren/Enalapril Combination on Morbi-mortality in Patients With Chronic Heart Failure

ATMOSPHERE
Start date: March 2009
Phase: Phase 3
Study type: Interventional

The study will evaluate the efficacy and safety of both aliskiren monotherapy and aliskiren/enalapril combination therapy as compared to enalapril monotherapy, on morbidity and mortality in patients with chronic heart failure (NYHA Class II - IV.

NCT ID: NCT00853450 Completed - Antiplatelet Effect Clinical Trials

Bleeding Time Study With AZD6482, Clopidogrel and ASA

Start date: February 2009
Phase: Phase 1
Study type: Interventional

The primary purpose of this study is to evaluate the effect of AZD6482 and clopidogrel on bleeding time when taken together with low-dose ASA.

NCT ID: NCT00853112 Terminated - Clinical trials for Hypertension, Pulmonary

A Research Study To Assess The Effectiveness And Safety Of Different Doses Of Oral PF-00489791 In The Treatment Of Adult Patients With Pulmonary Arterial Hypertension

Start date: April 2009
Phase: Phase 2
Study type: Interventional

Study will assess PF-00489791 efficacy and safety in Pulmonary Arterial Hypertension (PAH)

NCT ID: NCT00852982 Active, not recruiting - Type 2 Diabetes Clinical Trials

Exercise Effects on Cardiovascular Risk Factors, Quality of Life, Muscle Function in Type 2 Diabetes and Healthy Persons

SMIDIG
Start date: April 2006
Phase: N/A
Study type: Interventional

A sedentary lifestyle is known to be a risk factor to developing type 2 diabetes. The aim of this study was to determine the effects of adding regular Nordic walking to daily physical activity. Effects on quality of life, cardiovascular risk factors and functions in muscle cells will be determined.

NCT ID: NCT00852566 Completed - Clinical trials for Chronic Myeloid Leukemia

Randomized Study Comparing the Effect of Dasatinib and Imatinib on Malignant Stem Cells in Chronic Myeloid Leukemia

NordCML006
Start date: March 2009
Phase: Phase 2
Study type: Interventional

A randomized multi-center study comparing the effect of dasatinib and imatinib on malignant stem cells in newly diagnosed chronic phase chronic myeloid leukemia (CML) patients. The research hypothesis is that treatment with dasatinib 100 mg daily (QD) results in greater and more rapid depletion of the Philadelphia (Ph) -positive stem cell pool within 6 months of therapy than imatinib 400 mg QD in newly diagnosed CML patients. The study duration is 18 months and approximately 40 patients will be recruited to the study.