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NCT ID: NCT00915356 Completed - Atrial Fibrillation Clinical Trials

Intravenous Cardioversion of Atrial Fibrillation (AF) With AZD1305

Start date: May 2009
Phase: Phase 2
Study type: Interventional

This study is being carried out to see which dose of AZD1305 is safe and effective in cardioverting atrial fibrillation into normal heart rhythm.

NCT ID: NCT00915239 Completed - Healthy Clinical Trials

Symptom Evaluation After Cessation of a Proton Pump Inhibitor in Healthy Volunteers

Start date: January 2006
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether proton pump inhibitor (PPI) induced hypersecretion leads to acid related symptoms after treatment in healthy volunteers.

NCT ID: NCT00914459 Active, not recruiting - Hemophilia A Clinical Trials

Study Evaluating Safety And Efficacy Of Moroctocog Alfa (AF-CC) In Previously Treated Hemophilia A Patients

Start date: December 2009
Phase: Phase 4
Study type: Interventional

The study will be investigating pharmacokinetics, safety and efficacy in patients less than 12 years of age with severe hemophilia A that have been previously treated with Factor VIII products ( including blood products).

NCT ID: NCT00914368 Completed - Clinical trials for Coronary Artery Disease

Tailoring Of Platelet Inhibition to Avoid Stent Thrombosis

TOPAS-1
Start date: January 2009
Phase: Phase 2
Study type: Interventional

The primary objective of this study is to establish a cut off level of platelet inhibition that separates patients with or without previous stent occlusion with acute clinical onset while on aspirin and clopidogrel treatment within 6 months after coronary stenting for coronary artery disease.

NCT ID: NCT00914303 Completed - Healthy Clinical Trials

Study to Evaluate Different Extended Release (ER)-Formulations and Multiple Ascending Dosing of AZD3241

Start date: June 2009
Phase: Phase 1
Study type: Interventional

The aims of the study are to assess the safety, tolerability and pharmacokinetics of ER tablets of AZD3241 following multiple ascending doses administered to healthy male and female subjects including the effect of food.

NCT ID: NCT00913731 Completed - Clinical trials for Acute Psychotic Symptoms

Quality Project to Evaluate and Validate the FAST-O Rating Scale

FAST-O
Start date: May 2009
Phase: N/A
Study type: Observational

The purpose of this project is to test the reliability of the FAST-O Rating Scale in patients at acute wards or psychiatric intensive care units.

NCT ID: NCT00912964 Completed - Clinical trials for Urinary Bladder, Overactive

A Study to Test the Efficacy and Safety of the Beta-3 Agonist Mirabegron (YM178) in Patients With Symptoms of Overactive Bladder

CAPRICORN
Start date: April 28, 2009
Phase: Phase 3
Study type: Interventional

The study is intended to test efficacy, safety and tolerability of two doses of once daily (qd) Mirabegron against placebo to treat patients with symptoms of overactive bladder.

NCT ID: NCT00911469 Completed - Knee Osteoarthritis Clinical Trials

Study of AS902330 (rhFGF-18) Administered Intra-articularly in Patients With Knee Primary Osteoarthritis Who Are Candidates for Total Knee Replacement

Start date: November 2007
Phase: Phase 1
Study type: Interventional

Osteoarthritis (OA) is one of the most common diseases affecting the joints, usually those that are weight bearing such as the knees. OA is considered to be a disease of the cartilage in the joints even though it involves the whole joint, including the bone and synovium (thin lining of the joints which produces synovial fluid). With time, more and more of the cartilage is destroyed by the disease with inflammation commonly occurring. AS902330 is expected to increase the production and development of specific bone cells: chondrocytes and osteoblasts (cells that produce and maintain bone and cartilage). This is expected to lead to repair and regeneration of the cartilage, and a narrowing of the space width between the knee joints in a selected region of the knee.The purpose of this study is to see how safe treatment with AS902330 is, and to evaluate its effect on the knee cartilage. In addition, the study will also measure the effects of AS902330 in the blood.

NCT ID: NCT00910975 Completed - Clinical trials for Chronic Hepatitis C, Genotype 1

Individualized Duration of Peg-interferon/Ribavirin Treatment of Hepatitis C

TTG1
Start date: November 2007
Phase: Phase 4
Study type: Interventional

The purpose of the study is to investigate if the duration of treatment of hepatitis C with pegylated interferon and ribavirin can be individualized on the basis of how fast the hepatitis C virus concentration in the blood decreases, and if this is more cost-efficient than standard treatment.

NCT ID: NCT00909870 Completed - Venous Leg Ulcer Clinical Trials

Pivotal Trial of Dermagraft(R) to Treat Venous Leg Ulcers

DEVO
Start date: June 2009
Phase: Phase 3
Study type: Interventional

This study randomly assigns patients with venous leg ulcers to receive standard therapy (compression) alone or compression plus Dermagraft(R). Dermagraft is a device containing live human fibroblasts grown on an absorbable Vicryl mesh. Patients are seen weekly until they heal or the 16-week treatment period is complete. Follow-up visits are conducted monthly for three months in order to assess patients for longer term safety.