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NCT ID: NCT00761774 Completed - Epilepsy Clinical Trials

An Open-label, Multinational, Multicenter, Follow-up Study to Evaluate the Long-term Safety and Efficacy of Brivaracetam

Start date: November 2008
Phase: Phase 3
Study type: Interventional

The Sponsor wishes to develop brivaracetam as an anti-epileptic treatment in subjects 16 years and older with epilepsy. This study permits continued access to treatment for subjects who participated in a previous epilepsy study. The study will explore the long-term safety and efficacy of brivaracetam.

NCT ID: NCT00761501 Completed - Healthy Volunteer Clinical Trials

Phase I Study to Evaluate Bioavailability of Naproxen as PN400 Compared to Naproxen as Proxen S and Naprosyn E

Start date: September 2008
Phase: Phase 1
Study type: Interventional

The purpose of the study is to investigate the uptake in the body of naproxen; one of the two active substances in PN400. We also want to show that the body's uptake of naproxen given as PN400 is comparable to that of currently marketed naproxen tablets.

NCT ID: NCT00761449 Completed - AML Clinical Trials

Lenalidomide in High-risk MDS and AML With Del(5q) or Monosomy 5

Start date: October 2007
Phase: Phase 2
Study type: Interventional

The aim of this study is to investigate the efficacy of lenalidomide in high risk MDS or AML with chromosome 5 aberrations.

NCT ID: NCT00761384 Completed - B-cell Lymphoma Clinical Trials

High Dose, Absorbed Dose Adjusted 90Y-ibritumomab With Peripheral Blood Stem Cells (PBSC) Support in B-cell Lymphoma

HITT
Start date: April 2008
Phase: Phase 1/Phase 2
Study type: Interventional

90Y-ibritumomab given with stem cells support, based on absorbed dose escalation to the liver. Absorbed dose escalation starts at 12 Gy and is capped at 36 Gy to the liver.

NCT ID: NCT00760617 Completed - Influenza Clinical Trials

Evaluation of Safety and Immunogenicity of GSK Biologicals' Influenza Vaccine GSK2186877A in Adults 65 Years and Older

Start date: October 6, 2008
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the safety and immunogenicity of GlaxoSmithKline Biologicals' influenza vaccine GSK2186877A in adults 65 year of age and older. This protocol posting deals with objectives & outcome measures of the extension phase at year 1. The objectives & outcome measures of the primary phase are presented in a separate protocol posting (NCT number = 00540592).

NCT ID: NCT00760214 Completed - Hypertension Clinical Trials

Efficacy and Safety Study of Azilsartan Medoxomil Compared to Ramipril for Treating Essential Hypertension

Start date: January 2008
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine the efficacy and safety of azilsartan medoxomil, once daily (QD), compared to ramipril for treating Essential Hypertension.

NCT ID: NCT00758446 Completed - Allergic Rhinitis Clinical Trials

Efficacy and Safety Study of BLX-028914 in Subjects With Allergic Rhinitis

Start date: September 2008
Phase: Phase 2
Study type: Interventional

This is a phase II study in patients with seasonal allergic rhinitis (SAR) and will compare the effect versus placebo of two different oral doses of BLX-028914 in an allergen challenge model. BLX-028914, a selective phosphodiesterase-4 (PDE4) inhibitor with a promising safety profile,is currently under development for treatment of airway diseases by Orexo AB, Sweden. The aim of this study is to compare the effect, safety and tolerability of 14 days treatment with BLX-0289014 in patients with SAR in an allergen challenge model versus placebo.

NCT ID: NCT00757848 Completed - Cystic Fibrosis Clinical Trials

A Phase II , Placebo-controlled Study to Assess Efficacy of 28 Day Oral AZD9668 in Patients With Cystic Fibrosis

INCA
Start date: October 2008
Phase: Phase 2
Study type: Interventional

The purpose of this study is to investigate if treatment with AZD9668 for 28 days is effective in treating Cystic Fibrosis (CF) and if so how it compares to placebo (a substance which does not have any action).

NCT ID: NCT00757731 Completed - Clinical trials for Fibromyalgia Syndrome

FMS European Long-Term Study

Start date: September 2006
Phase: Phase 3
Study type: Interventional

Investigation of the long-term (12 months) efficacy and safety of milnacipran used in the treatment of fibromyalgia syndrome.

NCT ID: NCT00757419 Completed - Reflux Disease Clinical Trials

AZD3355 Dose-escalation Study in Healthy Males

Start date: September 2008
Phase: Phase 1
Study type: Interventional

The aim is to establish the maximal tolerated dose of AZD3355 for the selection of doses in the up-coming studies. This will be done by comparing single and repeated doses of AZD3355 to placebo ("inactive substance"). Safety and tolerability variables will be closely monitored throughout the study.