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NCT ID: NCT00757107 Completed - Osteoarthritis Clinical Trials

Taperloc Versus Taplerloc Microplasty

Start date: October 2011
Phase: N/A
Study type: Interventional

This evaluation is conducted to evaluate the safety and performance of two different stem lengths of the Taperloc Total Hip System. Per implant bone loss and migration of the stem are compared between the two groups with Dual-energy X-ray absorptiometry (DEXA) and radiostereomektric analysis

NCT ID: NCT00757016 Completed - Back Pain Clinical Trials

Injection Treatment of Corticosteroid to Pelvic Ligament Insertions on Women With Longlasting Backpain After Pregnancy

Start date: October 2004
Phase: N/A
Study type: Interventional

To evaluate the pain relief effect of locally injected corticosteroid treatment in women with long-lasting low back pain beginning in pregnancy. We hypothesize that the insertion of the sacrospinous ligament on the ischial spine would be a source of pain and therefore be a target for therapy. Primary outcome measure is reported pain intensity on visual analogue scale and secondary outcome measures number of pain-drawing locations, pain-provoking test results and tests of function.

NCT ID: NCT00756067 Completed - Clinical trials for Infections, Streptococcal

Evaluation of Pneumococcal Vaccine Formulations in Elderly

Start date: September 19, 2008
Phase: Phase 1
Study type: Interventional

The purpose of this observer-blind study is to evaluate the safety, reactogenicity and immunogenicity of pneumococcal vaccines in elderly. Subjects will be vaccinated twice with an interval of two months.

NCT ID: NCT00754988 Completed - Clinical trials for Diabetes Mellitus Type 2

A Study of Taspoglutide Versus Sitagliptin for the Treatment of Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin.

Start date: October 2008
Phase: Phase 3
Study type: Interventional

This 4 arm study will assess the efficacy, safety and tolerability of taspoglutide compared to sitagliptin and placebo in patients with type 2 diabetes mellitus inadequately controlled with metformin. Patients will be randomized to receive taspoglutide (10mg once weekly or 10mg once weekly for 4 weeks followed by 20mg once weekly), sitagliptin 100mg once daily or placebo, in a ratio of 2:2:2:1, in addition to their continued prestudy metformin treatment. After 24 weeks of treatment, patients on active treatment will continue on the same treatment and patients on placebo will be switched to taspoglutide 10mg once weekly or taspoglutide 20mg once weekly (after 4 weeks of taspoglutide 10mg once weekly). The anticipated time on study treatment is 2+ years, and the target sample size is 500+ individuals.

NCT ID: NCT00754715 Completed - Healthy Clinical Trials

Study to Assess Safety, Tolerability and Pharmacokinetics After Single Doses of AZD2516 to Healthy Volunteers

Start date: September 2008
Phase: Phase 1
Study type: Interventional

The primary purpose of this study is to assess the safety and tolerability of AZD2516 following administration of a single dose.

NCT ID: NCT00753688 Completed - Clinical trials for Sarcoma, Soft Tissue

Pazopanib Versus Placebo in Patients With Soft Tissue Sarcoma Whose Disease Has Progressed During or Following Prior Therapy

PALETTE
Start date: October 2008
Phase: Phase 3
Study type: Interventional

A randomized double blind phase III trial of Pazopanib versus placebo in patients with soft tissue sarcoma whose disease has progressed during or following prior therapy

NCT ID: NCT00753298 Completed - Clinical trials for Urinary Catheterization

A Randomized, Fully-blinded Parallel Groups Study of Catheter Materials Used for Clean Intermittent Catheterisation

Start date: January 2007
Phase: N/A
Study type: Interventional

The study is designed as a randomized, double-blind, parallel-group, multi centre study comparing perception and tolerability of investigational product and comparator. In the randomized part of the study the subjects will be given either LoFric Primo (POBE) or the comparator LoFric Primo (PVC) for use over 4 weeks. The hypothesis is that subject perception and satisfaction of POBE is equal to or better than for PVC.

NCT ID: NCT00752830 Completed - Healthy Clinical Trials

To Evaluate the Effect of Food on the Pharmacokinetics (PK) of AZD0328

Start date: September 2008
Phase: Phase 1
Study type: Interventional

The purpose of the study is to evaluate the effect of food on the pharmacokinetics of AZD0328 in healthy male volunteers. AZD0328 will be administered as a single oral dose (capsule) during two treatment periods, after food intake or during fasting condition.

NCT ID: NCT00752726 Completed - Obesity Clinical Trials

Effect of Orlistat in Body Composition

Start date: September 2008
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine if a 24 week weight loss program with orlistat 60 mg will produce greater changes in body composition compared to placebo.

NCT ID: NCT00751881 Completed - Multiple Sclerosis Clinical Trials

An Efficacy Study of Teriflunomide in Patients With Relapsing Multiple Sclerosis

TOWER
Start date: August 2008
Phase: Phase 3
Study type: Interventional

The primary objective of the study is to assess the effect of two doses of Teriflunomide, in comparison to placebo, on the frequency of multiple sclerosis (MS) relapses in patients with relapsing MS. Key secondary objective is to assess the effect of the two doses of teriflunomide, in comparison to placebo, on disability progression. Other secondary objectives are: - To assess the effect of the two doses of teriflunomide in comparison to placebo on: - Fatigue; - Health-related quality of life, a measure of the impact of the patient's health on his or her overall well being. - To evaluate the safety and tolerability of teriflunomide.