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NCT ID: NCT00918515 Completed - Healthy Clinical Trials

Study to Assess the Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of AZD3043

Start date: May 2009
Phase: Phase 1
Study type: Interventional

This is a Phase I, single centre, open label study to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics of intravenous AZD3043 after single ascending doses in healthy male volunteers.

NCT ID: NCT00918398 Completed - Healthy Clinical Trials

AZD1981 Bioavailability Study of Intravenous (IV) and Oral Formulations

Start date: June 2009
Phase: Phase 1
Study type: Interventional

The primary objective is to investigate the pharmacokinetics of AZD1981 given in different formulations and to measure renal clearance

NCT ID: NCT00917995 Completed - Parastomal Hernia Clinical Trials

Trial Concerning the Frequency of Parastomal Hernia With or Without a Mesh

STOMAMESH
Start date: January 2008
Phase: Phase 2/Phase 3
Study type: Interventional

Specific aim: To compare patients with colostomies with or without mesh at the primary operation. Primary endpoint is the incidence of parastomal hernia requiring surgery. All patients at participating centers scheduled for permanent colostomy, after signing informed consent and meeting inclusion criteria, will be randomised to formation of a stoma with or without mesh. If the inclusion criteria is fulfilled and informed consent is signed, the patient is randomised preoperatively.

NCT ID: NCT00917514 Completed - Ulcerative Colitis Clinical Trials

An Investigational Study to Test Usability of the Electronic Dosing Equipment Medicpen

Start date: June 2009
Phase: N/A
Study type: Observational

This is a study of the electronical dosing tool MedicPen and it's qualities with regards to user friendliness and medication compliance.

NCT ID: NCT00916409 Completed - Clinical trials for Glioblastoma Multiforme

Effect of NovoTTF-100A Together With Temozolomide in Newly Diagnosed Glioblastoma Multiforme (GBM)

Start date: June 2009
Phase: Phase 3
Study type: Interventional

The study is a prospective, randomly controlled pivotal trial, designed to test the efficacy and safety of a medical device, the NovoTTF-100A, as an adjuvant to the best standard of care in the treatment of newly diagnosed GBM patients. The device is an experimental, portable, battery operated device for chronic administration of alternating electric fields (termed TTFields or TTF) to the region of the malignant tumor, by means of surface, insulated electrode arrays.

NCT ID: NCT00915772 Completed - Clinical trials for Diabetes Mellitus, Type 2

Treatment of Type 2 Diabetes With Linagliptin 2.5 mg Bid + Metformin 500 or 1000 mg Bid and Metformin 1000 mg Bid

Start date: June 2009
Phase: Phase 3
Study type: Interventional

A phase III randomised, double-blind parallel group extension study to investigate the efficacy and safety of twice daily administration of the free combination of linagliptin 2.5 mg + metformin 500 mg or of linagliptin 2.5 mg + metformin 1000 mg versus monotherapy with metformin 1000 mg twice daily over 54 weeks in type 2 diabetic patients previously completing the double-blind part of study 1218.46

NCT ID: NCT00915356 Completed - Atrial Fibrillation Clinical Trials

Intravenous Cardioversion of Atrial Fibrillation (AF) With AZD1305

Start date: May 2009
Phase: Phase 2
Study type: Interventional

This study is being carried out to see which dose of AZD1305 is safe and effective in cardioverting atrial fibrillation into normal heart rhythm.

NCT ID: NCT00915239 Completed - Healthy Clinical Trials

Symptom Evaluation After Cessation of a Proton Pump Inhibitor in Healthy Volunteers

Start date: January 2006
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether proton pump inhibitor (PPI) induced hypersecretion leads to acid related symptoms after treatment in healthy volunteers.

NCT ID: NCT00914368 Completed - Clinical trials for Coronary Artery Disease

Tailoring Of Platelet Inhibition to Avoid Stent Thrombosis

TOPAS-1
Start date: January 2009
Phase: Phase 2
Study type: Interventional

The primary objective of this study is to establish a cut off level of platelet inhibition that separates patients with or without previous stent occlusion with acute clinical onset while on aspirin and clopidogrel treatment within 6 months after coronary stenting for coronary artery disease.

NCT ID: NCT00914303 Completed - Healthy Clinical Trials

Study to Evaluate Different Extended Release (ER)-Formulations and Multiple Ascending Dosing of AZD3241

Start date: June 2009
Phase: Phase 1
Study type: Interventional

The aims of the study are to assess the safety, tolerability and pharmacokinetics of ER tablets of AZD3241 following multiple ascending doses administered to healthy male and female subjects including the effect of food.