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NCT ID: NCT00128505 Completed - Clinical trials for Major Depressive Disorder

An International Extension Study of Corlux for Recurrent Psychotic Symptoms in Psychotic Major Depression

Start date: August 2005
Phase: Phase 3
Study type: Interventional

Corlux (mifepristone) is a new medication that modulates the body's use of a hormone called cortisol. Under normal conditions, cortisol and other hormones are created by the body in response to physical and emotional stress, triggering a healthy stress response. People who suffer from psychotic major depression may have unusually high levels of cortisol circulating within them or abnormal patterns of cortisol levels, overloading the stress response mechanism and causing symptoms of psychosis such as delusional thoughts or hallucinations. If Corlux can keep the body's cortisol receptors from being overloaded, the stress response system may return to normal function, which may result in improvement of symptoms. The purpose of this study is to allow patients who have already participated in an earlier 8 week study of Corlux versus placebo (an inactive pill) to receive additional courses of treatment with Corlux periodically if a psychotic episode should reappear during a period of one year.

NCT ID: NCT00126022 Completed - Atrial Fibrillation Clinical Trials

Intravenous Tedisamil in the Rapid Conversion of Atrial Fibrillation or Flutter to Normal Sinus Rhythm in Female Subjects

Start date: December 2004
Phase: Phase 3
Study type: Interventional

The purpose of this study is to demonstrate the ability of tedisamil to convert atrial fibrillation or flutter into normal sinus rhythm (NSR) in female patients.

NCT ID: NCT00125034 Completed - Colorectal Cancer Clinical Trials

Oxaliplatin and Cetuximab in First-line Treatment of Metastatic Colorectal Cancer (mCRC)

OPUS
Start date: July 2005
Phase: Phase 2
Study type: Interventional

This is an open label, randomized, controlled, multicenter phase II study comparing 5-FU/FA + oxaliplatin (FOLFOX-4) + cetuximab versus 5-FU/FA + oxaliplatin as first-line treatment for epidermal growth factor receptor (EGFR)-expressing mCRC.

NCT ID: NCT00124891 Terminated - Arrhythmias Clinical Trials

Study Evaluating GAP-486 in Non-sustained Ventricular Tachycardia

Start date: June 1, 2005
Phase: Phase 2
Study type: Interventional

To determine whether the administration of test article will decrease the occurrence of ventricular arrhythmias in patients who have acute coronary syndrome (unstable angina, ST segment elevated myocardial infarction or myocardial infarction without ST elevation).

NCT ID: NCT00124566 Completed - Prostate Cancer Clinical Trials

Study of Irofulven in Patients With Hormone-refractory Prostate Cancer

Start date: June 2004
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the efficacy and safety of irofulven-based regimens compared to mitoxantrone plus prednisone in patients with hormone-refractory prostate cancer (HRPC) whose disease has progressed following Taxotere based regimens.

NCT ID: NCT00122811 Active, not recruiting - Hypertension Clinical Trials

The Hypertension in the Very Elderly Trial (HYVET)

Start date: November 2000
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess the benefits and risks of treating very elderly (those aged 80 or older) individuals with hypertension.

NCT ID: NCT00119652 Completed - Depression Clinical Trials

Seroquel in Bipolar Depression Versus SSRI

EMBOLDEN II
Start date: May 2005
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether quetiapine is effective and safe in the acute treatment of bipolar depression and whether the effect is maintained when treatment is continued.

NCT ID: NCT00118703 Completed - Vasomotor Rhinitis Clinical Trials

Once-Daily Investigational Nasal Spray In Adults And Adolescents With Vasomotor Rhinitis

Start date: July 2005
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to compare the efficacy and safety of GW685698X 100mcg once daily (QD) aqueous nasal spray with vehicle placebo nasal spray in adult and adolescent subjects (12 years of age and older) with vasomotor rhinitis (VMR).

NCT ID: NCT00117325 Completed - Rhinitis, Vasomotor Clinical Trials

Study Of Adults And Adolescents With Vasomotor Rhinitis

Start date: July 11, 2005
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to compare the efficacy and safety of GW685698X 100mcg once daily (QD) aqueous nasal spray with vehicle placebo nasal spray in adult and adolescent subjects (12 years of age and older) with vasomotor rhinitis (VMR).

NCT ID: NCT00116753 Completed - Prostate Cancer Clinical Trials

A Comparative Study of Degarelix Three-month Depot in Three Different Dosing Regimens in Patients With Prostate Cancer

Start date: January 2005
Phase: Phase 2
Study type: Interventional

The rationale of the study was to evaluate different degarelix dosing regimens for a three-month interval that was to produce and maintain castration in prostate cancer patients through immediate and prolonged testosterone suppression, and to provide confirmatory evidence of the safety of degarelix.