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NCT ID: NCT02342886 Completed - Clinical trials for Tuberculosis, Pulmonary, Multi Drug-resistant

Shortening Treatment by Advancing Novel Drugs

STAND
Start date: February 2015
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the efficacy, safety and tolerability of a combination of moxifloxacin, PA-824, and pyrazinamide treatments with varying doses and treatment lengths from 4 to 6 months in subjects with drug-sensitive (DS) pulmonary TB compared to standard HRZE treatment. This study will also assess the efficacy, safety and tolerability of a combination of moxifloxacin, PA-824, and pyrazinamide treatments after 6 months of treatment in subjects with multi drug-resistant (MDR) pulmonary TB compared to a combination of moxifloxacin, PA-824, and pyrazinamide treatments in DS-TB subjects.

NCT ID: NCT02338245 Completed - Clinical trials for Metastatic Breast Cancer

Study of ASLAN001 in Combination With Capecitabine in MBC That Has Failed on Prior Trastuzumab

Start date: December 29, 2014
Phase: Phase 2
Study type: Interventional

This is an open-label, randomized, parallel group Phase 2A/2B study to evaluate the clinical activity of ASLAN001 in combination with capecitabine compared with lapatinib in combination with capecitabine in patients with HER2 positive metastatic breast cancer that has failed on prior trastuzumab therapy.

NCT ID: NCT02321436 Completed - Stroke Clinical Trials

Study to Assess Impact of Dysport Injections Early After Stroke on Upper Limb Spasticity Progression

ONTIME Pilot
Start date: December 2014
Phase: Phase 4
Study type: Interventional

The purpose of this study is to investigate if early administration (i.e. within 12 weeks after stroke) of Dysport® 500 U injections may delay the appearance or the progression of upper limb symptomatic spasticity.

NCT ID: NCT02309320 Completed - Clinical trials for Respiratory Syncytial Virus Infection

A Multicentre Study in Otherwise Healthy Infants and Toddlers Hospitalised For and Diagnosed With RSV Lower Respiratory Tract Infection to Evaluate the Safety, Tolerability, and Clinical Activity of ALX-0171

Start date: December 2014
Phase: Phase 1/Phase 2
Study type: Interventional

The primary objective of the study is to investigate the safety and tolerability of ALX-0171. The secondary objectives are to evaluate the clinical effect of ALX-0171 and to explore the pharmacodynamics (PD) and the systemic pharmacokinetics (PK) of ALX-0171.

NCT ID: NCT02306681 Completed - Clinical trials for Diabetes Mellitus, Type 2

A Survey on Low Blod Sugar Among Insulin-treated Patients With Diabetes

Start date: October 30, 2014
Phase:
Study type: Observational

This study is conducted globally. The aim of this study is to describe the proportion of patients with hypoglycaemic episodes and estimate the incidence of various types of hypoglycaemia in the retrospective and prospective periods.

NCT ID: NCT02303444 Completed - Thyroid Neoplasms Clinical Trials

An Observational Study in Differentiated Thyroid Cancer Which is Radioactive Iodine (RAI) Refractory to Assess the Use of Multikinase Inhibitors

RIFTOS MKI
Start date: April 8, 2015
Phase:
Study type: Observational

The purpose of the study was to assess the use of Multikinase Inhibitors (MKIs) in the treatment of patients with a progressive differentiated thyroid carcinoma (DTC) refractory to radioactive iodine (RAI) who do not have any symptoms.

NCT ID: NCT02302066 Completed - Dengue Fever Clinical Trials

Safety and Immunogenicity of Different Schedules of Takeda's Tetravalent Dengue Vaccine Candidate (TDV) in Healthy Participants

Start date: December 5, 2014
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the humoral immune responses to three different dose schedules of Takeda's Tetravalent Dengue Vaccine Candidate (TDV) administered subcutaneously in healthy participants between 2 and <18 years of age living in dengue endemic countries.

NCT ID: NCT02296138 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

Comparing the Efficacy of Tiotropium + Olodaterol (5/5 µg) Fixed Dose Combination (FDC) Over Tiotropium 5µg in Reducing Moderate to Severe Exacerbations in Patients With Severe to Very Severe Chronic Obstructive Pulmonary Disease.

Start date: January 13, 2015
Phase: Phase 3
Study type: Interventional

The overall objective is to assess the effect of once daily tiotropium + olodaterol fixed dose combination compared to 5 µg tiotropium (both delivered with the Respimat® inhaler) on moderate to severe COPD exacerbation in patients with severe to very severe COPD.

NCT ID: NCT02296125 Active, not recruiting - Clinical trials for Locally Advanced or Metastatic EGFR Sensitising Mutation Positive Non Small Cell Lung Cancer

AZD9291 Versus Gefitinib or Erlotinib in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer

FLAURA
Start date: December 3, 2014
Phase: Phase 3
Study type: Interventional

To assess the efficacy and safety of AZD9291 versus a standard of care epidermal growth factor receptor tyrosine kinase inhibitor in patients with locally advanced or Metastatic Non Small Cell Lung Cancer

NCT ID: NCT02287584 Completed - Schizophrenia Clinical Trials

Confirmatory Study of DSP-5423P in Patients With Schizophrenia

Start date: December 2014
Phase: Phase 3
Study type: Interventional

The primary objective of the study is to evaluate the efficacy of DSP-5423P compared with placebo in patients with schizophrenia.