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NCT ID: NCT00088803 Completed - Kidney Cancer Clinical Trials

DNA Variations in the Gene in Young Patients With Wilms' Tumor

Start date: August 2004
Phase: N/A
Study type: Observational

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is looking at DNA variations in the RASSF1A gene in young patients with Wilms' tumor.

NCT ID: NCT00084071 Completed - Pneumonia Clinical Trials

Tifacogin for the Treatment of Patients With Severe Community-Acquired Pneumonia

Start date: May 2004
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether tifacogin is effective and safe in the treatment of patients with severe community-acquired pneumonia.

NCT ID: NCT00081796 Completed - Breast Cancer Clinical Trials

Breast Cancer Trial of RPR109881 Versus Capecitabine in Male or Female Patients With Advanced Breast Cancer

Start date: April 2004
Phase: Phase 3
Study type: Interventional

The purpose of this clinical trial is to determine if RPR109881 is a better treatment than capecitabine (Xeloda) for advanced breast cancer in patients that no longer benefit from docetaxel and/or paclitaxel.

NCT ID: NCT00079482 Completed - Clinical trials for Acute Myeloid Leukemia

Study of CEP-701 (Lestaurtinib) in Patients With Acute Myeloid Leukemia (AML)

Start date: October 2003
Phase: Phase 2
Study type: Interventional

The purpose of the study is to determine whether CEP-701 given in sequence with induction chemotherapy increases the proportion of patients with relapsed acute myeloid leukemia (AML) who achieve a second complete remission (CR).

NCT ID: NCT00077636 Completed - Clinical trials for Hepatitis C, Chronic

ACCELERATE Study - A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Combination With COPEGUS (Ribavirin) in Interferon-Naive Patients With Chronic Hepatitis C (CHC) Infection.

Start date: December 2003
Phase: Phase 4
Study type: Interventional

This study will evaluate the efficacy and safety of different durations of treatment with PEGASYS combined with ribavirin in patients with CHC genotype 2 or 3 infection who have never previously received interferon (IFN) therapy. The anticipated time on study treatment is 3-12 months and the target sample size is 500+ individuals.

NCT ID: NCT00077623 Completed - Anemia Clinical Trials

A Study of Subcutaneous Mircera for the Treatment of Anemia in Dialysis Patients.

Start date: March 2004
Phase: Phase 3
Study type: Interventional

This study will assess the efficacy and safety of subcutaneous (sc) Mircera given as maintenance treatment for renal anemia in chronic kidney disease patients on dialysis who were previously receiving sc epoetin. The anticipated time on study treatment is 1-2 years and the target sample size is 100-500 individuals.

NCT ID: NCT00076336 Completed - Cirrhosis Clinical Trials

Telbivudine Versus Lamivudine in Adults With Decompensated Chronic Hepatitis B and Evidence of Cirrhosis

Start date: December 2003
Phase: Phase 3
Study type: Interventional

This research study was conducted to compare the safety and effectiveness of the investigational medication, LdT (Telbivudine) versus Lamivudine, a drug currently approved by the US, European and Asian Health Authorities for the treatment of Hepatitis B infection. The results for patients taking LdT will be compared to results for patients taking lamivudine.

NCT ID: NCT00075725 Completed - Clinical trials for Acute Lymphoblastic Leukemia

Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia

Start date: December 29, 2003
Phase: Phase 3
Study type: Interventional

This randomized phase III trial is studying dexamethasone to see how well it works compared to prednisone during induction therapy. This trial is also studying methotrexate and leucovorin calcium to see how well they work compared to methotrexate alone during maintenance therapy in treating patients with newly diagnosed acute lymphoblastic leukemia (ALL). Drugs used in chemotherapy, such as dexamethasone, prednisone, methotrexate, and leucovorin calcium, work in different ways to stop cancer cells from dividing so they stop growing or die. Giving more than one drug may kill more cancer cells. It is not yet known which combination chemotherapy regimen is more effective in treating acute lymphoblastic leukemia.

NCT ID: NCT00075582 Completed - Clinical trials for Adult Rhabdomyosarcoma

Vincristine, Dactinomycin, and Cyclophosphamide With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Low-Risk Rhabdomyosarcoma

Start date: September 4, 2004
Phase: Phase 3
Study type: Interventional

This phase III trial is studying how well combination chemotherapy and radiation therapy work in treating patients with newly diagnosed low-risk rhabdomyosarcoma. Drugs used in chemotherapy, such as vincristine, dactinomycin, and cyclophosphamide, work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy may kill more tumor cells. It is not yet known which treatment regimen is more effective in treating low-risk rhabdomyosarcoma.

NCT ID: NCT00075270 Completed - Neoplasms, Breast Clinical Trials

Paclitaxel With / Without GW572016 (Lapatinib) As First Line Therapy For Women With Advanced Or Metastatic Breast Cancer

Start date: January 2004
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine the efficacy and safety of an oral dual tyrosine kinase inhibitor (GW572016) in combination with paclitaxel compared to paclitaxel alone in first line advanced or metastatic breast cancer.