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NCT ID: NCT03428789 Completed - Breast Cancer Clinical Trials

Nerve Coaptation in DIEP Flap Breast Reconstruction

Start date: September 2015
Phase: N/A
Study type: Observational

The sensory recovery of the breast remains an undervalued aspect of breast reconstruction and surgical reinnervation is not regarded as a priority by most reconstructive surgeons. A prospective study was conducted of all patients who underwent either innervated or non-innervated DIEP flap breast reconstruction in Maastricht University Medical Center and returned for follow-up between September 2015 and July 2017. Semmes-Weinstein monofilaments were used for sensory testing of the breast. This study showed that nerve coaptation in DIEP flap breast reconstruction resulted in a significantly improved sensation of the reconstructed breast compared to non-innervated flaps.

NCT ID: NCT03428100 Completed - Atopic Dermatitis Clinical Trials

A Long-term Study of Baricitinib (LY3009104) With Topical Corticosteroids in Adults With Moderate to Severe Atopic Dermatitis That Are Not Controlled With Cyclosporine or for Those Who Cannot Take Oral Cyclosporine Because it is Not Medically Advisable

BREEZE-AD4
Start date: May 15, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine the efficacy and safety of baricitinib in combination with topical corticosteroids in participants with moderate to severe atopic dermatitis who have experienced failure to cyclosporine or are intolerant to, or have contraindication to cyclosporine.

NCT ID: NCT03427203 Completed - Ileostomy - Stoma Clinical Trials

Assessment of New Ostomy Devices in Subjects Having an Ileostomy

Start date: January 9, 2018
Phase: N/A
Study type: Interventional

The study investigates the performance of three new adhesives with regard to leakage and the skin condition.

NCT ID: NCT03426124 Completed - Clinical trials for Pulmonary Embolism and Thrombosis

An International Pulmonary Embolism Registry Using EKOS

KNOCOUT PE
Start date: March 1, 2018
Phase:
Study type: Observational [Patient Registry]

This registry is designed to understand acoustic pulse thrombolysis (APT) treatment regimens used as standard of care globally for pulmonary embolism. The registry will include individuals who have already received the APT treatment and those that will undergo APT treatment.

NCT ID: NCT03425539 Completed - Fabry Disease Clinical Trials

Efficacy and Safety of Lucerastat Oral Monotherapy in Adult Subjects With Fabry Disease

MODIFY
Start date: June 21, 2018
Phase: Phase 3
Study type: Interventional

This study aimed to determine the efficacy and safety of lucerastat oral monotherapy in adult subjects with Fabry disease.

NCT ID: NCT03422068 Completed - Clinical trials for Idiopathic Pulmonary Fibrosis

This Study Tests Different Doses of BI 1015550 in Patients With Idiopathic Pulmonary Fibrosis (IPF). The Study Tests How BI 1015550 is Taken up by the Body and How Well it is Tolerated.

Start date: March 16, 2018
Phase: Phase 1
Study type: Interventional

The primary objective is to investigate safety and tolerability of BI 1015550 in patients with IPF. The secondary objectives are to evaluate the pharmacokinetics (PK) of BI 1015550 in patients with IPF.

NCT ID: NCT03420742 Completed - Clinical trials for Carcinoma, Advanced ALK+ or ROS1+Non-Small-Cell Lung, Neoplasm, Advanced ALK+ or ROS1+Solid Tumors

A Phase 1 Drug-Drug Interaction Study Between Brigatinib and the CYP3A Substrate, Midazolam, in Participants With ALK-Positive or ROS1-Positive Solid Tumors

Start date: June 26, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this study is to characterize the effect of repeat-dose administration of brigatinib 180 milligram (mg) once daily (QD) on the single-dose pharmacokinetics (PK) of midazolam.

NCT ID: NCT03420235 Completed - Clinical trials for Idiopathic Pulmonary Fibrosis

Home Monitoring in Idiopathic Pulmonary Fibrosis; Improving Use of Anti-fibrotic Medication and Quality of Life

Start date: January 9, 2018
Phase: N/A
Study type: Interventional

In this study it will be investigate whether a home monitoring program improves disease-specific health-related quality of life (HRQOL) for patients with idiopathic pulmonary fibrosis (IPF) through appropriate medication use and subsequently results in better objective and subjective outcomes.

NCT ID: NCT03419702 Completed - Clinical trials for Overweight and Obesity

Almonds and Health Effects on Metabolism, Vascular Function and Cognition

Start date: January 10, 2018
Phase: N/A
Study type: Interventional

The primary objective of the proposed study is to examine and understand the impact of long-term almond consumption on chronic glucose metabolism in subjects with impaired glucose tolerance and/or impaired fasting glucose.

NCT ID: NCT03419572 Completed - Clinical trials for Renal Cell Carcinoma

Non-interventional Study of Cabozantinib in Adults With Advanced Renal Cell Carcinoma

CASSIOPE
Start date: April 24, 2018
Phase:
Study type: Observational

The objective of this study is to understand the utilization of cabozantinib in subjects with advanced renal cell carcinoma (RCC) following prior VEGF-targeted therapy in real life settings in terms of dose modifications due to adverse events (AEs) when used as a second line therapy or third and later line therapy. Other patterns of use of cabozantinib will also be described.