Clinical Trials Logo

Filter by:
  • Not yet recruiting  
  • Page [1] ·  Next »
NCT ID: NCT03800472 Not yet recruiting - Healthy Clinical Trials

A Study Investigating the Safety, Absorption and Elimination of GLPG3312, a New Drug in the Treatment of Inflammatory Diseases

Start date: January 2019
Phase: Phase 1
Study type: Interventional

The purpose of this study is to investigate how safe 2 different formulations (immediate-release (IR) and modified-release (MR) tablets) of the new compound GLPG3312 are and how well they are tolerated when they are administered to healthy volunteers. Immediate-release and modified-release tablets contain the same active ingredient, but the modified-release tablet is covered with a protective layer, so it will dissolve in the intestines and not in the stomach. GLPG3312 has not been administered to humans before. Next to assessing the safety and tolerability, the purpose of this study is to investigate how food affects how quickly and to what extent GLPG3312 in a modified release formulation is absorbed and eliminated from the body. In addition, the effect of GLPG3312 on the body will be investigated by evaluating the effect of GLPG3312 on markers of the immune response.

NCT ID: NCT03800290 Not yet recruiting - Healthy Clinical Trials

Human Beta-2 Adrenergic Stimulation and Muscle Glucose Uptake

Start date: February 1, 2019
Phase: Phase 2
Study type: Interventional

Type 2 diabetes mellitus (T2DM) and its associated cardiovascular comorbidities have developed into a leading cause of death in western countries. Medical and non-medical treatments have failed to counter this 'diabesity' epidemic, fostering the need for novel therapies. In this context, we have recently demonstrated robust improvements in insulin sensitivity in T2DM patients upon 10 days of mild cold acclimatisation, which proved to be primarily mediated through an increased skeletal muscle glucose uptake and occurred independent of improvements in classical regulatory pathways (i.e. insulin signalling or AMPK activation). Given this background, it was recently shown that skeletal muscle glucose uptake can also be mediated through an alternative novel pathway involving β2-adrenergic receptors, through activation of mTORC2. Thus, animal studies showed robust improvements in glucose homeostasis in diabetic rodents upon prolonged treatment with a low-dose of the selective β2-agonist clenbuterol. This project aims to investigate the human relevance of this novel β2-mTORC2 pathway and intents to investigate if prolonged supplementation with the selective β2-adrenergic agonist clenbuterol improves glucose disposal in healthy, lean male individuals. As such, this study serves as a proof-of-principle to identify if this novel pathway could potentially be used as a novel treatment target to improve glucose homeostasis T2DM patients.

NCT ID: NCT03793946 Not yet recruiting - Quality Improvement Clinical Trials

A Digital Antimicrobial Stewardship Smartphone Application to Combat AMR: the AB-assistant

AB-assistant
Start date: September 2019
Phase: N/A
Study type: Interventional

Optimal prescribing of antimicrobials is becoming increasingly challenging because of the growing complexity of guidelines and constantly changing distribution of infectious pathogens. Prescribing antimicrobials appropriately according to local guidelines optimizes therapy for the individual patient and reduces the emergence of resistance. By adapting and evaluating a smartphone based app containing local guidelines we aim to study appropriate prescribing of antimicrobials by physicians in three hospitals (Netherlands, Sweden and Switzerland).

NCT ID: NCT03793777 Not yet recruiting - Cognitive Function Clinical Trials

The Effect of Aronia With and Without Guarana Extract on Cognitive Function

Start date: January 14, 2019
Phase: N/A
Study type: Interventional

There is a great interest in improving cognitive performance, including memory and attention. Improved attention is desirable for a large group of people because it is linked to improved performance . Students and professionals can benefit from improved attention and thus performance in academic and other work environments. In addition, cognitive functioning also plays an important role in sports. Various cognitive skills, including attention, reaction time and motor function, have shown that they can influence sport performance. A completely natural supplement with aronia melanocarpa (and guarana) extract could be a promising way to naturally improve cognitive performance.

NCT ID: NCT03787238 Not yet recruiting - Migraine Clinical Trials

A Randomized, Multicenter, Study for the prEvention and Acute Treatment of Migraine (REAL)

REAL
Start date: March 1, 2019
Phase: N/A
Study type: Interventional

This is a randomized study for the prevention and acute treatment of migraine using open label nVNS and standard of care versus standard of care.

NCT ID: NCT03783429 Not yet recruiting - Heart Failure Clinical Trials

Digoxin Evaluation in Chronic Heart Failure: Investigational Study In Outpatients in the Netherlands

DECISION
Start date: April 2019
Phase: Phase 4
Study type: Interventional

Digoxin is the oldest, market-authorized drug for heart failure (HF), and very cheap. A large trial with digoxin, the DIG trial, executed in the early nineties revealed a highly significant reduction in HF hospitalizations, but no effect on mortality. A post-hoc analysis of the DIG trial suggests that low serum concentrations of digoxin may not only improve HF hospitalizations but also mortality in chronic HF patients. To confirm these retrospective analyses, a prospective, randomized, placebo-controlled trial is necessary to establish the position of digoxin in the contemporary treatment of HF. Therefore, the investigators examine whether low-level, aiming for serum concentrations 0.5-0.9ng/mL, digoxin is beneficial in HF patients with reduced or mid-range ejection fractions (LVEF <50%).

NCT ID: NCT03780673 Not yet recruiting - Liver Cirrhoses Clinical Trials

Efficacy of the Combination of Simvastatin Plus Rifaximin in Patients With Decompensated Cirrhosis to Prevent ACLF Development

2018-001698-25
Start date: December 17, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

The aim of this study is to assess the efficacy of oral administration of simvastatin plus rifaximin in patients with decompensated cirrhosis to halt the progression of the disease as assessed by prevention of the development of ACLF

NCT ID: NCT03771898 Not yet recruiting - Clinical trials for Metachromatic Leukodystrophy (MLD)

A Study of Intrathecal SHP611 in Participants With Late Infantile Metachromatic Leukodystrophy

Start date: April 30, 2019
Phase: Phase 2
Study type: Interventional

The primary purpose of this study is to evaluate the effects of intrathecal (IT) administration of SHP611 on gross motor function, using the Gross Motor Function Classification in Metachromatic Leukodystrophy (GMFC-MLD) compared with matched historical control data in children with metachromatic leukodystrophy (MLD).

NCT ID: NCT03767244 Not yet recruiting - Prostatic Neoplasms Clinical Trials

A Study of Apalutamide in Participants With High‑Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy

Start date: February 15, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine if treatment with androgen deprivation therapy (ADT) plus apalutamide (with or without abiraterone acetate with prednisone [AAP]) before and after radical prostatectomy in participants with high-risk localized or locally advanced prostate cancer results in an improvement in pathological complete response (pCR) rate and metastasis-free survival (MFS), as compared to ADT plus placebo.

NCT ID: NCT03766035 Not yet recruiting - Clinical trials for Primary Sclerosing Cholangitis (PSC)

Cholangioscopy in PSC

Start date: December 2018
Phase: N/A
Study type: Interventional

To demonstrate the clinical utility of the addition of per oral cholangioscopy (POCS) to standard endoscopic retrograde cholangiopancreatography (ERCP) with brushing cytology for diagnosis and early detection of cholangiocarcinoma in patients diagnosed with primary sclerosing cholangitis (PSC).