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NCT ID: NCT03706365 Not yet recruiting - Prostate Cancer Clinical Trials

A Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib (LY2835219) in Participants With Prostate Cancer

Start date: October 17, 2018
Phase: Phase 2
Study type: Interventional

This study is being done to see how safe and effective abemaciclib is when given together with abiraterone acetate plus prednisone in participants with metastatic castration resistant prostate cancer.

NCT ID: NCT03705403 Not yet recruiting - Metastatic Disease Clinical Trials

IMMUNOtherapy and Stereotactic ABlative Radiotherapy (IMMUNOSABR) a Phase II Study

Start date: December 1, 2018
Phase: Phase 2
Study type: Interventional

This will be a phase II trial testing if the combination of stereotactic body radiation therapy (SBRT) and L19-IL2 improves the progression free survival in patients with limited metastatic non-small cell lung cancer (NSCLC). The trial consists of one cohort with two arms; C-arm and an E-arm. Patients with oligometastatic disease will receive stereotactic body radiotherapy to all metastatic sites (max 3 sites irradiated) and patients with diffuse metastatic lesions (max 10) will receive radiotherapy to max 3 sites. In the experimental arm, immunotherapy will be given after irradiation.

NCT ID: NCT03702530 Not yet recruiting - Clinical trials for Necator Americanus Infection

Immunisation, Treatment and Controlled Human Hookworm Infection

Start date: March 2019
Phase: N/A
Study type: Interventional

24 healthy volunteers will be immunized with three times 50 L3 larvae or placebo followed by treatment with albendazol and subsequently challenged with twice 50 L3 larvae.

NCT ID: NCT03696836 Not yet recruiting - Clinical trials for Osteo Arthritis Knee

AIR (Artificial Implant for Medial Meniscus Replacement) Study

Start date: October 11, 2018
Phase: N/A
Study type: Interventional

The AIR Study is a multi-center, prospective, interventional clinical trial with the objective to evaluate the safety and performance of the Trammpolin® meniscus prosthesis system.

NCT ID: NCT03694210 Not yet recruiting - Acute Pancreatitis Clinical Trials

EndoRotor DEN (Direct Endoscopic Necrosectomy)Trial

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

A prospective, single arm, open label, multi-center, trial to evaluate the safety and effectiveness of the Interscope EndoRotor® Resection System in subjects requiring direct endoscopic necrosectomy (DEN) with walled off pancreatic necrosis (WOPN).

NCT ID: NCT03693573 Not yet recruiting - Clinical trials for Renal Cell Carcinoma

A Study of Atezolizumab in Combination With Bevacizumab in Untreated Locally Advanced or Metastatic Clear Cell or Non-Clear Cell Renal Cell Carcinoma

Start date: January 11, 2019
Phase: Phase 3
Study type: Interventional

Study MO39939 is an open-label, single-arm, multicenter trial in patients with unresectable, locally-advanced or metastatic, clear or non-clear cell renal cell carcinoma (RCC) who have not received prior systemic therapy (who are treatment naïve in either the [neo]adjuvant or advanced/metastatic setting for clear and non-clear cell RCC). The study consists of a Screening Period, a Treatment Period, an End of Treatment Visit occurring approximately 30 days after the last dose of study medication, and a Follow-Up Period of 4 years after last patient enrolled.

NCT ID: NCT03688971 Not yet recruiting - Clinical trials for Seborrheic Dermatitis

Omiganan Twice a Day (BID) in Patients With Facial Seborrheic Dermatitis

Start date: October 2018
Phase: Phase 2
Study type: Interventional

To explore the efficacy and pharmacodynamic effects of omiganan topical gel in facial seborrheic dermatitis.

NCT ID: NCT03688412 Not yet recruiting - Clinical trials for Cardiac Electrophysiology

Transvenous Lead Removal Post-Market Clinical Study

Start date: November 2018
Study type: Observational

This prospective, multicenter, post-market clinical study was designed to evaluate the outcomes of lead extraction of cardiovascular implantable electronic devices (CIED) using Cook catheter and lead extraction devices for any indication it is used in the commercial setting within the United States and Europe. The purpose of this clinical study is to collect data on the performance of the Cook lead extraction devices for the purpose of supporting publications and presentations

NCT ID: NCT03685890 Not yet recruiting - Melanoma Clinical Trials

Evaluating the Effect of Nivolumab for Patients With In-transit Metastases Treated With Isolated Limb Perfusion

Start date: December 2018
Phase: Phase 1/Phase 2
Study type: Interventional

To evaluate safety and the effect of isolated limb perfusion together with nivolumab as a way to increase efficacy and give further insights in early immunological mechanisms. In the first phase Ib part, 20 patients will be enrolled and followed for a minimum of 3 months. An independent data safety monitoring board (DSMB) will continuously review safety and judge the seriousness of the events and also recommend the study to stop if necessary. If the DSMB do not find safety issues, the trial will continue as a phase II trial.

NCT ID: NCT03684772 Not yet recruiting - Actinic Keratosis Clinical Trials

Topical Ionic Contra-Viral Therapy in Actinic Keratosis

Start date: September 2018
Phase: Phase 2
Study type: Interventional

To explore the pharmacodynamics and evaluate safety, tolerability and clinical efficacy of ICVT comprised of digoxin and furosemide (dual agent), digoxin (single agent), furosemide (single agent) in patients with AK.