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NCT ID: NCT02022137 Completed - Liver Cirrhosis Clinical Trials

Fructans, Lactitol and Lactose in Minimal Hepatic Encephalopathy

Start date: October 2013
Phase: N/A
Study type: Interventional

As an alternative for the treatment of Minimal Hepatic Encephalopathy (MHE) Agave fructans have shown prebiotic effects, and have shown to improve function of the digestive system, control and induce glycemic effect satiety. Therefore the impact of the fermentation of such prebiotic in the gut may contribute to improving health and quality of life of patients with MHE.

NCT ID: NCT02021292 Completed - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension

MERIT-1
Start date: August 20, 2014
Phase: Phase 2
Study type: Interventional

Study to evaluate if macitentan is efficient, safe and tolerable enough to be used for treatment of inoperable chronic thromboembolic pulmonary hypertension (CTEPH).

NCT ID: NCT02019472 Completed - Clinical trials for Arthritis, Rheumatoid

A Study Comparing Sirukumab (CNTO 136) Monotherapy With Adalimumab (HUMIRA®) Monotherapy in the Treatment of Active Rheumatoid Arthritis

SIRROUND-H
Start date: April 4, 2014
Phase: Phase 3
Study type: Interventional

The primary objective is to investigate the efficacy of sirukumab monotherapy compared with adalimumab monotherapy in biologic naïve subjects with active rheumatoid arthritis who are intolerant to methotrexate, who are considered inappropriate for treatment with methotrexate or who are inadequate responders to methotrexate.

NCT ID: NCT02019264 Completed - Obesity Clinical Trials

A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors

CAMELLIA-TIMI
Start date: January 24, 2014
Phase: Phase 4
Study type: Interventional

This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group study in overweight and obese subjects with cardiovascular (CV) disease and/or multiple CV risk factors.

NCT ID: NCT02017301 Recruiting - Infection Clinical Trials

Vector Analysis of Body Composition in Hospitalized Cirrhotic Patients

Start date: November 2012
Phase:
Study type: Observational

Patients with acute decompensation of cirrhosis, or acute on chronic liver failure often present with malnutrition, and due to the in-hospital stay, their nutritional intake can vary widely, with several periods of fasting, and sometimes insufficient nutritional support. Therefore patients are prone to develop malnutrition or, the already present malnutrition worsens its status. Our aim is to evaluate the daily changes in nutritional status in patients with acute decompensation of cirrhosis and evaluate the changes in plasma and serum biomarkers.

NCT ID: NCT02017119 Completed - Cirrhosis Clinical Trials

Comparison Between Lactulose and Lactulose-Paraffin in Cirrhotic Patients

Start date: January 2011
Phase: Phase 2
Study type: Interventional

Hepatic encephalopathy (HE) is an important complication of liver cirrhosis. Lactulose is a first line treatment for HE, but the adherence to this treatment is relatively low, due to side effects such as diarrhea, distention, etc.

NCT ID: NCT02016482 Completed - Plaque Psoriasis Clinical Trials

A Study to Evaluate the Safety and Efficacy of Adalimumab in Subjects With Chronic Plaque Psoriasis and Nail Psoriasis

Start date: January 2014
Phase: Phase 3
Study type: Interventional

This study is being conducted to assess the safety and efficacy of adalimumab in subjects with nail psoriasis.

NCT ID: NCT02015520 Completed - Clinical trials for Rheumatoid Arthritis

Phase IIB Dose Ranging Study in Subjects With Moderate to Severe Rheumatoid Arthritis

Start date: June 2012
Phase: Phase 2
Study type: Interventional

The primary purpose of this study is to identify an appropriate dose of study medication.

NCT ID: NCT02013167 Terminated - Clinical trials for Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia

Blinatumomab Versus Standard of Care Chemotherapy in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)

Start date: January 3, 2014
Phase: Phase 3
Study type: Interventional

The primary objective was to evaluate the effect of blinatumomab on overall survival when compared to standard of care (SOC) chemotherapy.

NCT ID: NCT02012179 Completed - Heart Failure Clinical Trials

SODIUM-HF: Study of Dietary Intervention Under 100 MMOL in Heart Failure

SODIUM-HF
Start date: March 24, 2014
Phase: Phase 3
Study type: Interventional

SODIUM-HF is a multicenter clinical trial in ambulatory patients with chronic HF to evaluate the efficacy of a low sodium containing diet on a composite clinical outcome composed of of all-cause mortality, cardiovascular hospitalizations and cardiovascular emergency department visits. The hypothesis of this study is that patients following a low-sodium containing diet will have fewer clinical events (fewer hospital readmissions or emergency department visits, longer survival) than those randomized to Usual Care.