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Infection clinical trials

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NCT ID: NCT03672214 Not yet recruiting - Clinical trials for Urinary Tract Infections

Caesarean Delivery With or Without an Indwelling Bladder Catheter

Start date: November 1, 2018
Phase: N/A
Study type: Interventional

The aim of this study is to compare the incidence of catheter associated culture-based urinary tract infection (UTI) after elective CD with or without preoperative placement of a urinary catheter.

NCT ID: NCT03672006 Not yet recruiting - Clinical trials for Central Venous Catheter Thrombosis

t-PA Prophylaxis to Prevent Catheter-associated Thrombosis and Infection

TOPCAT
Start date: October 2018
Phase: Phase 2
Study type: Interventional

The purpose of this pilot study is to test feasibility of concept, consent and enrollment rates, and mechanics of study designed to assess if intra-catheter dwells of tissue plasminogen activator (t-PA) is effective in decreasing the rate of clinically diagnosed central line associated blood stream infection (CLABSI) or venous thromboembolism (VTE) in central venous catheters (CVC) compared to standard of care heparin dwell.

NCT ID: NCT03671967 Not yet recruiting - Bacteremia Clinical Trials

PipEracillin Tazobactam Versus mERoPENem for Treatment of Bloodstream Infections Caused by Cephalosporin-resistant Enterobacteriaceae- a Non-inferiority Randomized Controlled Trial (PETERPEN)

PETERPEN
Start date: January 2019
Phase: Phase 4
Study type: Interventional

Data regarding optimal treatment for extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae blood-stream infection are lacking. Observational studies show conflicting results when comparing treatment with combination beta-lactam-beta-lactamase inhibitor and carbapenems. We aim to evaluate the effect of definitive treatment with meropenem vs. piperacillin-tazobactam on the outcome of patients with bacteremia due to cephalosporin-non-susceptible Enterobacteriaceae. We hypothesize that piperacillin-tazobactam is non-inferior to meropenem.

NCT ID: NCT03667937 Not yet recruiting - Clinical trials for Bacterial Infections

Effectiveness of a Hydrophobic Dressing for Microorganisms' Colonization and Infection Control of Vascular Ulcers

CUCO-UV
Start date: September 30, 2018
Phase: Phase 4
Study type: Interventional

This study will determine the effectiveness of CUTIMED® hydrophobic dressings against AQUACEL® silver dressings in bacterial colonization of vascular ulcers.

NCT ID: NCT03667703 Not yet recruiting - Infection Clinical Trials

Stress Ulcer Prophylaxis Versus Placebo in Critically Ill Infants With Congenital Heart Disease

SUPPRESS-CHD
Start date: December 1, 2018
Phase: N/A
Study type: Interventional

Infants with congenital heart disease often require an intervention during their first year of life. Infants are generally admitted to a cardiac intensive care unit and are routinely prescribed stress ulcer prophylaxis to decrease acid release from the stomach to prevent stress ulcer formation. However, these medicines may not be safe and could put infants at increased risk for hospital-acquired infections, necrotizing enterocolitis and alteration to the infant's microbiome. The investigators plan to assess the feasibility of conducting a prospective, blinded randomized control trial to determine the safety of withholding stress ulcer prophylaxis in critically ill infants with congenital heart disease. In addition, the investigators plan to examine the changes to the infant's microbiome through oral, gastric and stool samples and compare hospital-acquired infections.

NCT ID: NCT03666871 Not yet recruiting - HIV Infections Clinical Trials

CCR5-modified CD4+ T Cells for HIV Infection

TRAILBLAZER
Start date: December 2, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

A Comparative Study of Autologous CD4+ T Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728 versus ex vivo Expanded Unmodified Autologous CD4+ T Cells in Treated HIV-1 Infected Subjects

NCT ID: NCT03665467 Active, not recruiting - Clinical trials for Urinary Tract Infections

The Global Prevalence of Infections in Urology Study

GPIU
Start date: November 30, 2003
Phase:
Study type: Observational

Urology departments from all over the world are invited to join the Global Prevalence Study on Infections in Urology (GPIU-study) and the GPIU Prostate Biopsy Side Study. The GPIU study is taking part annually in November since 2003. European urologists were the first group of specialist to register hospital acquired infections on an international level. More than 20.000 patients have been screened and more than 2000 patients are currently listed in this database. Why? Infectious complications after urological procedures, such as prostate biopsy and increasing antimicrobial resistance are posing significant threats to modern urology The GPIU-study is a combined quality improvement initiative and a scientific study. Once the participating departments have filled in the report forms they will get access to statistics showing the accumulated results for all participating hospitals. The participants can anonymously compare their own results with hospitals from all over the World. The GPIU-study application has been designed as an instrument to ongoing follow-up of the development of important factors related to infection on international, national and local levels. Take responsibility for the future of urology - join the GPIU-studies! http://gpiu.esiu.org Prof. Dr. Florian M.E. Wagenlehner, MD, PhD Clinic for Urology, Pediatric Urology and Andrology University Clinic Giessen, Germany GPIU study coordinator Prof. Truls E. Bjerklund Johansen, MD, PhD Urology Department, Oslo University Hospital, Chairman ESIU Oslo (NO) GPIU Study coordinator Zafer Tandogdu Northern Institute for Cancer Research Newcastle University, UK Dominic Althaus Software engineer Giessen (Ger)

NCT ID: NCT03664518 Not yet recruiting - Clinical trials for Chronic HBV Infection

to Evaluate the Efficacy and Safety of Eltrombopag for Thrombocytopenia With Chronic HBV Infection

Start date: October 1, 2018
Phase: Phase 2
Study type: Interventional

Primary Objective: To evaluate the efficacy of 6-week Eltrombopag to treat thrombocytopenia associated with chronic hepatitis B virus infection. Secondary Objective: To evaluate the efficacy and safety of 6-week and 22-week Eltrombopag to treat thrombocytopenia associated with chronic hepatitis B virus infection.

NCT ID: NCT03661814 Recruiting - Clinical trials for Surgical Wound Infection

Prophylactic NPWT to Reduce SSI in Colorectal Surgery

Start date: August 13, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to see if the Negative Pressure Wound Therapy (NPWT) system is effective and safe for the prevention of superficial and deep incisional surgical site infections (SSI) in high risk patients within 30 days after elective colorectal surgery. It has been shown that patients with an IBD, patients undergoing a reoperation or patients with certain comorbidities are at a higher risk of developing an SSI. The NPWT device is a wound dressing with a vacuum system that can be placed over abdominal wounds. The study will include up to 400 patients at this single site, where these high risk patients will be randomized to receive either one of two arms. The first arm involves the placement of the NPWT device in the immediate postoperative period over abdominal wounds after clean/contaminated colorectal surgical procedures. The device would then be left on for 5 days. The second arm would be standard of care and would entail routine postoperative protocols. Subjects will then be seen once at a 30 day (± 7 days) follow-up visit to assess for the development of SSIs.

NCT ID: NCT03659344 Completed - Clinical trials for Infection, Surgical Site

Efficacy of Antimicrobial Coating Suture Coated Vicryl Plus Compared With Vicryl in Reduced Surgical Site Infection of Dental Implant Surgeries: A Uni-Blind Randomized Clinical Trial Study

Start date: September 1, 2016
Phase: N/A
Study type: Interventional

Patients randomly aligned in 2 groups.Vicryl plus sutures were used in group 1 for closing subperiostal flaps after dental implant surgeries and vicryl sutures were used in group 2.