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Infection clinical trials

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NCT ID: NCT03737669 Not yet recruiting - Clinical trials for Transfusion-Transmitted Infectious Disease

Ugandan Mirasol Trial

Start date: March 16, 2019
Phase: Phase 3
Study type: Interventional

This is a prospective, randomized, double-blind, controlled study to determine the effectiveness of Mirasol-treated fresh whole blood (FWB) versus Standard-issue FWB for preventing transmission of transfusion-transmitted infections (TTIs). The incidence of pre-defined viral, bacterial, or parasitic TTIs in previously negative participants will be assessed by changes in laboratory findings at multiple time points over the course of the clinical trial.

NCT ID: NCT03736421 Not yet recruiting - Infection Clinical Trials

Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients

Start date: November 10, 2018
Study type: Observational

The overall goal of this multicenter project is to characterize the expected normal range of Peripheral IntraVenous Volume Analysis (PIVA) values during a euvolemic state, and how those ranges may be altered by comorbidities; the relationship between PIVA and intravenous volume administration during resuscitation of infected patients with presumed hypovolemia; and, the relationship between PIVA and volume decreases during diuresis in acute heart failure patients with hypervolemia.

NCT ID: NCT03736096 Recruiting - Cystic Fibrosis Clinical Trials

Molecular Diagnosis of Respiratory Viral Infections on Sputum From Cystic Fibrosis Patients

Start date: October 3, 2018
Study type: Observational

The main objective of this project is to evaluate the agreement between nasopharyngeal and sputum specimens in terms of detection of viral infection in Cystic Fibrosis (CF) participants.This is a 12-month national, multicenter prospective study (7 centers). Inclusions concern CF participants (children or adults) with signs of acute respiratory infection seen in consultation or hospitalized in their CF Research Center. A molecular viral multiplex search is performed on both nasopharyngeal and expectoration collected samples for each included participant. Determination of viral detection agreement between the two CF respiratory samples is then performed.

NCT ID: NCT03734484 Not yet recruiting - Sepsis Clinical Trials

Gram Type Infection-Specific Sepsis Identification Using Machine Learning

Start date: May 1, 2022
Phase: Phase 2
Study type: Interventional

The focus of this study will be to conduct a prospective, randomized controlled trial (RCT) at Cape Regional Medical Center (CRMC), Oroville Hospital (OH), and UCSF Medical Center (UCSF) in which a Gram type infection-specific algorithm will be applied to EHR data for the detection of severe sepsis. For patients determined to have a high risk of severe sepsis, the algorithm will generate automated voice, telephone notification to nursing staff at CRMC, OH, and UCSF. The algorithm's performance will be measured by analysis of the primary endpoint, time to antibiotic administration. The secondary endpoint will be reduction in the administration of unnecessary antibiotics, which includes reductions in secondary antibiotics and reductions in total time on antibiotics.

NCT ID: NCT03733093 Recruiting - HIV Clinical Trials

PREVAIL VIII: A CoHOrt Clinical, Viral, and ImmuNOlogic Monitoring Study of People Living With Retroviral Infection in Liberia (HONOR)

Start date: November 14, 2018
Study type: Observational

Background: There are many people living with human immunodeficiency virus (HIV) infection in Liberia. Most experts consider HIV an epidemic there. Researchers want to collect health data from Liberians with HIV over several years. This may help HIV prevention and treatment programs in Liberia. Objective: To learn more about how HIV affects people in Liberia. Eligibility: People with HIV in Liberia Design: Participants will be screened with a blood sample. Participants will visit the study clinic about 10 times over 3 years. They will need to return to the clinic after some visits to get test results. The visits will be closer together during the first part of the study and less frequent later. At each study visit, participants will: - Have a brief physical exam - Answer questions about how they are feeling and what medicines they are taking - Have blood taken from an arm vein by a needle - Give urine samples Participants ages 12 years or older may be asked questions about HIV risk behaviors. These include sex practices and drug use. Participants ages 18 years or older may be asked how their HIV infection makes them feel emotionally. Participants may be asked to join a research substudy. This will be about tuberculosis (TB) testing in people with HIV. For this substudy, participants will have a TB skin test. A small amount of liquid will be injected under the skin on the arm. Participants will return to the clinic a few days later. The test area will be checked. They will get their test results.

NCT ID: NCT03732365 Not yet recruiting - Non-healing Wound Clinical Trials

Phase 2 Randomized Study to Compare Ultrasonic Drug Delivery to Standard of Care for the Treatment of Infections in Non-Healing Wounds

Start date: February 1, 2019
Phase: Phase 2
Study type: Interventional

This is a randomized study to compare the safety and efficacy of a single dose of up to 2 grams of cefazolin administered using a new drug delivery method called Ultrasonic Drug Delivery (UDD), combined with standard of care (SOC) antibiotic therapy, oral or IV, compared to standard of care (SOC) antibiotic therapy alone, in treating chronic wounds with skin and soft tissue infection, containing gram-positive pathogens, in lower extremities.

NCT ID: NCT03730766 Recruiting - Clinical trials for Helicobacter Pylori Infection

Analysis of the Impact of Helicobacter Pylori on Salivary Microbiome in Adults

Start date: August 1, 2018
Phase: Phase 4
Study type: Interventional

Helicobacter pylori (H. pylori), a bacteria transmitted from human to human through upper digestive tract as well as fecal-oral transmission, had infected more than half of people around the world. However, the quantity of H. pylori in oral cavity and its influence on oral microbiota remains to be unclear. The aim of the present study was to examine the effects of H. pylori infection as well as its eradication on oral microbiota.

NCT ID: NCT03730701 Not yet recruiting - Stroke Clinical Trials

Make my Day - Primary Prevention of Stroke

Start date: March 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the feasibility and effect of an ongoing digital, person-centered prevention program with a focus on primary prevention. The program is aiming to enable lifestyle change and to promote healthy activity patterns to prevent stroke.

NCT ID: NCT03729778 Recruiting - HIV Infections Clinical Trials

Impact of HIV-1 and Aging on Mucosal Vaccine Responses

Start date: January 18, 2017
Phase: Phase 4
Study type: Interventional

The purpose of this study is to learn more about both HIV-1 infection and advancing age, alone and in combination, and their association with increased risk of serious infection and impaired response to the Prevnar 13 vaccine.

NCT ID: NCT03728608 Recruiting - Infection Clinical Trials

Optimal Feeding Tube Dwell Time in VLBW Infants to Reduce Feeding Tube Contamination

Start date: May 10, 2017
Phase: N/A
Study type: Interventional

The study team will determine whether a decreased feeding tube dwell time will reduce feeding tube contamination