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NCT ID: NCT03585179 Not yet recruiting - Melasma Clinical Trials

Oral and Topical Tranexamic Acid for the Treatment of Melasma

TRANEXAMICO
Start date: August 1, 2018
Phase: Phase 3
Study type: Interventional

Tranexamic acid has been used for treating melasma due to its effect on decreasing the activity of tyrosinase and melanogenesis. This 3-arm clinical trial will asess the efficacy and safety of oral and topical tranexamic acid as monotherapy compared with topical hydroquinone for 12 weeks in adults with melasma. The primary outcome will be the percentage of reduction at 12-week period of mMASI and melanin index. The incidence of adverse effects will be reported at weeks 4, 8 and 12.

NCT ID: NCT03583047 Enrolling by invitation - Clinical trials for Endothelial Dysfunction

Intracoronary Features in the Prognosis of Endothelial Dysfunction and MACES in Population With Acute Coronary Syndrome

iphoneSPACE
Start date: January 15, 2016
Phase:
Study type: Observational

Coronary Artery Disease (CAD) is common in Mexico, while morbidity and mortality is high. Drug therapy can relieve angina pain and stabilize plaque, but it is not able to re-flow a coronary artery. Balloon angioplasty and/or stent placement, re-establishes coronary blood flow; however, the risk of re-stenosis and/or development of new coronary events remains latent. Endothelial damage, reflected by the degree of endothelial dysfunction, inflammation and oxidative stress, promotes atherogenesis, which plays a central role in the pathophysiology of CAD. These mechanisms have been studied in animal models; however, it is widely unknown whether it influences the coronary circulation in humans. Therefore the present study explores the impact of an intracoronary profile of biomarkers of endothelial dysfunction, inflammation and oxidative stress on the prognosis of coronary remodeling and new adverse cardiovascular events in patients with chronic stable coronary syndrome undergoing angioplasty and stent placement.

NCT ID: NCT03582449 Recruiting - Hunter Syndrome Clinical Trials

Intensive Pharmacovigilance Program for Elaprase (SHP ELA-701)

Start date: January 19, 2018
Phase:
Study type: Observational

The purpose of this non-interventional, observational study which is conducted in Mexico is to evaluate the safety profile of elaprase (idulsurfase) in participants with hunter syndrome (mucopolysaccharydosis II) being treated with elaprase.

NCT ID: NCT03578926 Recruiting - Astigmatism Clinical Trials

Performance of Two Toric Silicone Hydrogel Contact Lenses

Start date: June 18, 2018
Phase: N/A
Study type: Interventional

Prospective study to evaluate the clinical performance of fanfilcon A toric contact lens and senofilcon A toric contact lens after two weeks of wear.

NCT ID: NCT03578341 Recruiting - Clinical trials for Immune System Diseases

Oral Colostrum and Its Effect on Immune System

Start date: June 1, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this project is to increase the serum immunological defenses of premature infants less then 32 weeks of gestation by administrating colostrum in the oropharyngeal mucosa versus placebo

NCT ID: NCT03577600 Recruiting - Cerebral Palsy Clinical Trials

Palliative Treatment in Children With CP Through Cytotron®

CP
Start date: September 1, 2018
Phase: N/A
Study type: Interventional

This is a randomized, blinded, two-arm, clinical study. This study is expected to last for approximately 6 months, comprised of 4-8 weeks of enrollment period, 28 days of treatment and 3 months of follow up. The enrollment will be completed prior to the beginning of initial treatment. The study will be closed when 50 subjects have completed the study. The enrollment will be randomized 1:1 to Cytotron treatment or mock treatment (placebo). Upon the completion of the study period, the placebo group will receive treatment.

NCT ID: NCT03563898 Recruiting - Fluid Overload Clinical Trials

Feasibility and Safety in the Management of Fluid Overload in Peritoneal Dialysis Patients Through Sweat Stimulation With the Use of Portable Sauna Bath, Pilot Study

SWEAT
Start date: May 28, 2018
Phase: N/A
Study type: Interventional

The objective of this pilot study is to evaluate the feasibility and safety of the use of diaphoresis achieved through the use of portable sauna baths in peritoneal dialysis patients with fluid overload

NCT ID: NCT03562286 Recruiting - Myelomeningocele Clinical Trials

Open Spina Bifida Fetoscopic Repair Project

Start date: October 1, 2017
Phase: N/A
Study type: Interventional

The aim of the study is to assess a new fetal surgery approach to repair open spina bifida. The fetal group hypothesis is to perform a minimally invasive procedure using a fetoscopic technique in order to access to amniotic cavity and make the endoscopic repair. This approach will allow investigators to make the closure of the defect and avoid the use of an hysterotomy, reducing the risk of maternal complications as uterine dehiscence (rupture), hemorrhage and preterm premature rupture of membranes (PPROM), the patient also will be able to have a vaginal delivery.

NCT ID: NCT03559140 Completed - Post-operative Pain Clinical Trials

Reduction of Post-endodontic Pain After 3 Irrigation Regime

RPEP
Start date: January 4, 2018
Phase: N/A
Study type: Interventional

The goal of this research was to relate the occurrence of post-endodontic pain after single-visit RCT using there irrigating regime. Methodology: All 216 patients had upper or lower molar, premolar or anterior teeth selected for conventional RCT for prosthetic reasons detected with only vital pulps. Of the sample of 216 teeth, were selected to just one method for instrumentation and different manner to irrigate. All instruments were used with a micro motor (VDW, Munich Germany). Reciproc instruments. Final irrigation with cold (8oC, 2.5 oC and room temperature 17% EDTA and saline solution served as a lubricants.

NCT ID: NCT03559127 Completed - Post Operative Pain Clinical Trials

Pain Reduction Using Two Cold Irrigating Protocols in Teeth With Vital Pulps.

EP18
Start date: March 7, 2018
Phase: N/A
Study type: Interventional

The goal of this clinical research was to relate the incidence of post-endodontic pain after one-visit root canal treatment using two cold protocols of irrigation. Methodology: All 240 patients had upper or lower molar, premolar or anterior teeth selected for conventional root canal treatment for prosthetic reasons detected with only vital pulps (symptomatic or asymptomatic condition). Of the sample of 240 teeth, were selected to different manner to irrigate. Reciproc instruments were used with a micro motor (VDW, Munich Germany). Final irrigation with cold (6oC, 2.5 oC and room temperature 17% EDTA and saline solution served as a lubricants.