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NCT ID: NCT03422185 Completed - Hypertension Clinical Trials

Understanding Local Determinants of Cardiovascular Disease and Diabetes

Start date: May 2013
Phase: N/A
Study type: Observational

Cross-sectional survey of all adults residing in two defined geographical regions in urban Lilongwe and rural Karonga District. Participants were interviewed, had anthropometric measures taken, and had fasting blood specimens taken.

NCT ID: NCT03399318 Not yet recruiting - Malaria Clinical Trials

Aggressive Antipyretics for Fever Reduction in CNS Malaria

Start date: April 1, 2018
Phase: Phase 2
Study type: Interventional

The study will examine whether prophylactic and scheduled treatment with acetaminophen and ibuprofen can decrease the maximum temperature experienced during the acute illness in children with CNS malaria.

NCT ID: NCT03385590 Not yet recruiting - Healthy Clinical Trials

Feasibility and Acceptability of a Soy-fiber-maize Complementary Food in Malawi.

Start date: September 1, 2018
Phase: N/A
Study type: Interventional

The purpose of this intervention study is to assess the feasibility and acceptability of soy-fiber-maize versus soy-maize complementary foods on bowel movement frequency, transit time, growth, gastrointestinal symptoms, microbiota composition and activity.

NCT ID: NCT03385252 Recruiting - Infant Malnutrition Clinical Trials

The Mazira Project: An Evaluation of Eggs During Complementary Feeding in Rural Malawi

Start date: January 22, 2018
Phase: N/A
Study type: Interventional

The Mazira Project is a study of the effect of egg consumption on growth, development and gut health of infants in Malawi. The study randomly assigns infants to receive one egg per day over six months or to receive an equivalent value of food at the end of six months. Growth, achievement of developmental milestones, gut microbiome composition and other measures of nutritional status are compared between the two groups to determine whether regular egg consumption benefits Malawian infants.

NCT ID: NCT03376217 Not yet recruiting - Clinical trials for Malaria in Pregnancy

Assessing the Effectiveness of Community Delivery of Intermittent Preventive Treatment in Pregnancy (IPTp) in Malawi

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

The overall aim of the study is to learn whether utilization of Health Surveillance Assistants (HSAs) for delivery of intermittent preventive treatment of malaria in pregnant women (IPTp) can increase coverage of three or more IPTp doses compared to IPTp delivery only at antenatal clinics (ANC), while at the same time improve or maintain ANC attendance. This will be a cluster randomized trial, including a total of 20 health facilities (HF) which will be randomly assigned to either the intervention (10) or non-intervention group (10); all HSAs affiliated with a HF will be in the same group.

NCT ID: NCT03300648 Not yet recruiting - Malaria, Cerebral Clinical Trials

Treating Brain Swelling in Pediatric Cerebral Malaria

Start date: January 8, 2018
Phase: Phase 3
Study type: Interventional

This study evaluates the effectiveness of two interventions in Malawian children with cerebral malaria at high risk of death. One-third of the participants will receive treatment as usual, one-third will receive treatment as usual and be placed on a mechanical ventilator, and one-third will receive treatment as usual plus intravenous hypertonic saline.

NCT ID: NCT03284866 Not yet recruiting - HIV Infection Clinical Trials

HPV Vaccine Therapy in Reducing High-Grade Cervical Lesions in Patients With HIV and HPV

Start date: June 2018
Phase: Phase 3
Study type: Interventional

This randomized phase III trial studies how well human papillomavirus (HPV) vaccine therapy works in reducing high-grade cervical lesions in patients with human immunodeficiency virus (HIV) and HPV. Vaccines made from HPV peptides or antigens may help the body build an effective immune response to kill the HPV virus and prevent cervical lesions from developing or coming back after being removed.

NCT ID: NCT03271307 Recruiting - HIV Infections Clinical Trials

Use of HIV Self-Test Kits to Increase Identification of HIV-Infected Individuals and Their Partners

Start date: September 25, 2017
Phase: N/A
Study type: Interventional

This is an unblinded cluster-randomized study to evaluate the feasibility and cost-effectiveness of HIV self-testing strategies compared to standard of care in outpatient departments (OPD) and sexually transmitted infection (STI) clinics. The first aim of the study will be conducted in Malawi at 15 clusters among 15,000 individuals (15 years or older) to test the feasibility and cost-effectiveness of group HIV self-testing for patients in OPD and STI clinic waiting areas. The second aim of the study will be conducted in Malawi at 15 clusters among 7,500 individuals (15 years or older) to test the feasibility and cost-effectiveness of HIV self-testing for partners of newly identified HIV-positive clients.

NCT ID: NCT03236922 Active, not recruiting - Clinical trials for Vesicovaginal Fistula

Autologous Slings With Vesico-Vaginal Fistula Repair

Start date: June 2016
Phase: N/A
Study type: Interventional

It is clear from multiple accounts in the literature that patients with a vesico-vaginal fistula (VVF) involving the bladder neck and/or proximal urethra have a high likelihood of residual incontinence. Performing subsequent surgeries after the initial VVF repair risks additional complications. Therefore, placement of an autologous sling at the time of initial VVF repair would not only assist in covering the fistula, but would also imitate the physiologic support that would theoretically improve urethral function. A rectus fascia sling would most naturally provide this support and warrants testing against the success of the PC sling. Using the Goh scoring criteria, Goh class 3 and 4 VVF's are the type most involving the urethra. Therefore, this group of patients is the target population for this study. As there is currently no standard of care for repairing large urethral defects, this procedural technique combined with otherwise standardized fistula repair would not introduce any foreseeable harm to patients.

NCT ID: NCT03226379 Recruiting - Clinical trials for Cryptococcal Meningitis

Driving Reduced AIDS-associated Meningo-encephalitis Mortality

Start date: April 23, 2016
Phase: N/A
Study type: Observational

The DREAMM project is investigating whether point of care tests within a diagnostic and treatment algorithm together with support and additional training of laboratory and clinical staff will reduce two and ten week all-cause mortality of HIV-associated meningo-encephalitis in LMICs.