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NCT ID: NCT02613169 Completed - Tuberculosis Clinical Trials

Infant TB Infection Prevention Study

iTIPS
Start date: August 2016
Phase: Phase 2
Study type: Interventional

Randomized controlled trial (RCT) of isoniazid (INH) vs. no INH to prevent Mycobacterium tuberculosis infection in HIV-exposed uninfected (HEU) infants.

NCT ID: NCT02598388 Completed - Clinical trials for Hemorrhagic Fever, Ebola

Safety, Tolerability and Immunogenicity Study of 2-dose Heterologous Regimens for Ebola Vaccines Ad26.ZEBOV/MVA-BN-Filo

Start date: December 10, 2015
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the safety, tolerability and immunogenicity of different vaccination schedules of Ad26.ZEBOV and MVA-BN-Filo administered intramuscularly (IM) as 2-dose heterologous regimens in healthy and in HIV-infected adults.

NCT ID: NCT02591420 Completed - HIV Infections Clinical Trials

Safety and Virologic Effect of a Human Monoclonal Antibody (VRC01) Administered Intravenously to Adults During Early Acute HIV Infection

Start date: April 2016
Phase: Phase 1
Study type: Interventional

This study will evaluate the safety and virologic effect of an experimental human monoclonal antibody (mAb), VRC-HIVMAB060-00-AB (VRC01), alone or in combination with antiretroviral therapy (ART), in adults during early acute HIV infection.

NCT ID: NCT02568215 Completed - HIV Infections Clinical Trials

Evaluating the Safety and Efficacy of the VRC01 Antibody in Reducing Acquisition of HIV-1 Infection in Women

Start date: May 2016
Phase: Phase 2
Study type: Interventional

This study will evaluate the safety and efficacy of the human monoclonal antibody (mAb) VRC-HIVMAB060-00-AB (VRC01) in preventing HIV-1 infection in high-risk, HIV-uninfected women.

NCT ID: NCT02564783 Completed - Clinical trials for Burden of Surgical Disease in Western Kenya

The Burden of Pediatric Surgical Conditions in Rural Kenya

Start date: October 2015
Phase: N/A
Study type: Observational

PURPOSE OF THE STUDY The main purpose of this study is to find out what is the true burden of surgical conditions in pediatric population in a well defined geographical rural area in western Kenya.

NCT ID: NCT02564523 Completed - Clinical trials for Hemorrhagic Fever, Ebola

Safety, Tolerability and Immunogenicity Study of 3 Prime-boost Regimens for Ebola Vaccines Ad26.ZEBOV/MVA-BN-Filo in Healthy Adults, Children and Human Immunodeficiency Virus Positive (HIV+) Adults

Start date: November 6, 2015
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the safety, tolerability and immunogenicity of three heterologous prime-boost regimens for Ebola vaccines Ad26.ZEBOV and MVA-BN-Filo. The study will include healthy adults and elderly participants, HIV infected participants and healthy children in 2 age strata.

NCT ID: NCT02550067 Completed - HIV Clinical Trials

The Evidence for Contraceptive Options and HIV Outcomes Trial

ECHO
Start date: December 14, 2015
Phase: N/A
Study type: Interventional

The ECHO Study is an open-label randomized clinical trial that will compare three highly effective, reversible methods of contraception (including a non-hormonal method) to evaluate whether there is a link between use of any of these methods and increased risk of acquiring HIV infection. A randomized clinical trial among about 7,800 women in four countries, ECHO will deliver evidence to support and guide individual, policy and programmatic decisions on contraception for women at risk of acquiring HIV infection.

NCT ID: NCT02543892 Completed - Pneumonia Clinical Trials

A Study of a Vaccine for Pneumonia in Adults and Toddlers in Kenya

Start date: August 10, 2016
Phase: Phase 1/Phase 2
Study type: Interventional

This study aimed to determine whether PATH-wSP, a vaccine against a germ that causes pneumonia, is safe and induces immune responses in adults and toddlers. The study vaccine was compared to placebo. First adults received 2 injections of a lower dose of the vaccine or placebo, 28 days apart. Since the lower dose was considered safe, a higher dose was tested. Once the safety was established in adults the lower and higher dose was tested in toddlers, starting with the lower dose and then the higher dose.

NCT ID: NCT02527941 Completed - HIV Infections Clinical Trials

Effect of Bacterial Vaginosis on HIV Susceptibility and Female Genital Immunology

Start date: August 2015
Phase: Phase 1
Study type: Interventional

A non-randomized, interventional, longitudinal clinical study to quantify the impact of bacterial vaginosis treatment on HIV susceptibility and genital immunology in Kenyan women.

NCT ID: NCT02527135 Completed - HIV Infection Clinical Trials

Text Messaging to Improve HIV Testing Among Young Women in Kenya

T2T
Start date: September 2013
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether regularly scheduled HIV sensitization text messages (SMS) are effective in increasing HIV testing rates among young women in Kenya.