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NCT ID: NCT03243396 Not yet recruiting - Depression Clinical Trials

Building and Sustaining Interventions for Children: Task-sharing Mental Health Care in Low-resource Settings

BASIC
Start date: January 2018
Phase: N/A
Study type: Interventional

The study will take place in Kanduyi, a sub-county in southern Kenya, and focuses on children orphaned by one or two parents. Growing evidence demonstrates that orphaned children in low- and middle-income countries are at high risk of post-traumatic stress, but mental health professionals are largely unavailable in this area. Research suggests that some mental health treatments can be delivered effectively in low- and middle-income countries using a task sharing approach, in which lay counselors with little or no prior mental health experience are trained to provide treatment. Whetten and Dorsey's past studies have suggested that partnering with two government sectors, education and health, could be a low-cost and sustainable strategy to implement task sharing mental health services. By training teachers (via the education sector) and community health volunteers (via the health sector) to provide mental health care, a larger population could potentially be reached. Before programs are scaled-up country-wide, it's important to know not only what policies to implement but also their predicted implementation success and intervention effectiveness. This study aims to identify implementation strategies and examine whether the education and/or health sectors are productive partners in scaling up task sharing mental health care in future programs.

NCT ID: NCT03235518 Recruiting - Clinical trials for Human Immunodeficiency Virus

A Combination HIV Prevention Strategy for Young Women at Risk for HIV

IPrEP
Start date: June 28, 2017
Phase: N/A
Study type: Observational

The purpose of this study is to conduct formative research to inform the design and implementation of combination prevention interventions, including pre-exposure prophylaxis (PrEP) for female sex workers (FSW), as well as to inform recruitment and retention strategies for female sex workers and their male clients in Kenya.

NCT ID: NCT03224390 Recruiting - Clinical trials for Contraception Behavior

A Pilot Study to Estimate the Impact of a Screening and Referral Service on Contraceptive Use

Start date: July 12, 2017
Phase: N/A
Study type: Interventional

The specific aim of this pilot study is to estimate the impact of a new digital health service on the uptake of family planning among Kenyan women with an unmet need for contraception. Enrolled women will be randomized to a control arm or an encouragement arm that will receive a special invitation to try the new service.

NCT ID: NCT03223532 Active, not recruiting - Male Circumcision Clinical Trials

Randomized Trial Comparing PrePex Day 7 Foreskin Removal Procedure (FRP) to a Day 0 PrePex FRP .

Start date: April 26, 2017
Phase: Phase 3
Study type: Interventional

A Prospective, Randomized, Open Label Trial Comparing PrePex™ Day 7 (FRP) to a PrePex Day 0 FRP of Male Circumcision in Resource Limited Settings.

NCT ID: NCT03208725 Recruiting - Sepsis Clinical Trials

Childhood Acute Illness and Nutrition Network

CHAIN
Start date: November 2016
Phase: N/A
Study type: Observational

The CHAIN Network aims to identify modifiable biomedical and social factors driving the greatly increased risk of mortality among young undernourished children admitted to hospital with acute illness, as inpatients and after discharge. The study will inform priorities, risks and targeting for multi-faceted interventional trials. CHAIN is a multi-centre cohort study with a nested case control analysis of stored biological samples. Study sites are located in Africa and South Asia. Children will be recruited at admission to hospital, stratified by nutritional status. Exposures will be assessed at admission, during hospitalisation, at discharge, and at two time points after discharge. The main outcomes of interest are mortality, re-admission to hospital and failure of nutritional recovery up to 180 days after discharge. To determine community health norms, an additional sample of children living in the same communities will be enrolled and assessed at one time point only.

NCT ID: NCT03208179 Not yet recruiting - Pregnancy Clinical Trials

Improving PRegnancy Outcomes With Intermittent preVEntive Treatment in Africa

IMPROVE
Start date: September 2017
Phase: Phase 3
Study type: Interventional

This study evaluates the efficacy and safety of monthly intermittent preventive treatment using dihydroartemisinin piperaquine (DP) alone or in combination with azithromycin (AZ) compared to sulphadoxine-pyrimthamine (SP) for the prevention of malaria in pregnant women in the second and third trimester.

NCT ID: NCT03201510 Active, not recruiting - HIV Clinical Trials

Feasibility of HIV Prevention Cohort Studies Among Men Who Have Sex With Men in Sub-Saharan Africa

Start date: July 2015
Phase: N/A
Study type: Observational

This study aims to determine the feasibility of recruiting and retaining men who have sex with men (MSM) in a multi-country prospective cohort study in preparation for human immunodeficiency virus (HIV) prevention studies in sub-Saharan Africa (SSA).

NCT ID: NCT03188237 Completed - Pregnancy Related Clinical Trials

AfyaJamii (Parenting Well): Evaluating the Feasibility of a Group Antenatal/Well-child Care Model in Pregnancy in Kenya

Start date: January 2012
Phase: N/A
Study type: Interventional

This proposal is a program evaluation of a group care delivery model designed for pregnant women that was implemented as a pilot project in Teso District, Kenya in 2012.

NCT ID: NCT03187873 Recruiting - Pregnancy Related Clinical Trials

Chamas for Change Validation

Start date: May 1, 2017
Phase: N/A
Study type: Interventional

This team has shown that chamas can be tailored to increase the uptake of health services in pregnancy and infancy, sustain themselves beyond the period of funding and become integrated within a county's health strategy. However, further investment is warranted to validate this intervention in a new region to ensure the positive effects on MNCH are a result of chamas and can be replicated. The purpose of this study is to demonstrate that chamas are an effective service-delivery platform for improving women's and children's health and well-being in western Kenya.

NCT ID: NCT03174236 Not yet recruiting - Clinical trials for Antibiotic Resistance

First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition

FLACSAM
Start date: June 5, 2017
Phase: Phase 3
Study type: Interventional

Children with severe malnutrition who are admitted sick to hospitals have a high mortality(death rate), usually because of infection. All children with severe malnutrition admitted to hospitals are treated with antibiotics(medication used to kill bacteria). However, the current antibiotics used in hospitals may not be the most effective. It is possible that the antibiotics that are currently used after initial antibiotics should be used first. No studies have been carried out to determine if the current antibiotics used for treating malnourished children who are sick and admitted in hospital are the most appropriate. The aim of this study is to find out if a changed antibiotic system for children with malnutrition is safe, reduces the risk of death and improves nutritional recovery.