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NCT ID: NCT03492931 Recruiting - Sickle Cell Disease Clinical Trials

PK Study of Ticagrelor in Children Aged Less Than 24 Months, With Sickle Cell Disease (HESTIA4)

HESTIA4
Start date: March 28, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this Phase I study is to investigate the pharmacokinetic properties of ticagrelor in pediatric patients from 0 to less than 24 months with sickle cell disease. Ticagrelor dose level adjustment will require a Protocol amendment and regulatory approval

NCT ID: NCT03490058 Recruiting - HIV/AIDS Clinical Trials

The Prevention Options for Women Evaluation Research (POWER) Cohort

Start date: June 14, 2017
Phase:
Study type: Observational

The POWER Cohort study is a PrEP implementation project to demonstrate Pre-exposure prophylaxis (PrEP) delivery for young women in Cape Town and Johannesburg, South Africa and Kisumu, Kenya.

NCT ID: NCT03485573 Recruiting - Trauma Clinical Trials

Improvement of Trauma Care Quality by Implement Trauma Register in a Middle Income Country

Start date: March 12, 2018
Phase:
Study type: Observational [Patient Registry]

Every year more people die from traumatic injuries than from infections such as malaria, tuberculosis, and HIV/AIDS. About 3000 people are killed annually on Kenyan roads. Hospital trauma registers have played a key role in the advancement of patient-based research and trauma care. Trauma registers offer a unique opportunity to document patient characteristics and audit outcomes, thereby creating a platform for clinical research. One of these systems is the ICD-based Injury Severity Score (ICISS) derived from and validated on hospital data to predict hospital death. The establishment of the register enables us to compare the trauma care quality with other existing or upcoming trauma registers, in different settings.

NCT ID: NCT03468114 Recruiting - Diarrhea Clinical Trials

The Safe Start Trial - Kisumu, Kenya

Start date: March 26, 2018
Phase: N/A
Study type: Interventional

This a cluster randomised controlled trial (cRCT) to evaluate the effect of a novel food hygiene intervention on infant health.

NCT ID: NCT03460730 Completed - Clinical trials for Pneumonia, Pneumococcal

Dynamics of the Immune Response in Children to the 23-valent Pneumococcal Capsular Polysaccharide Vaccine (Pneumovax)

Start date: November 4, 2004
Phase: Phase 1
Study type: Interventional

To explore a further dimension of susceptibility to disease, the investigators tested the hypothesis that natural variation exists in the rapidity of IgG responses following exposure to pneumococcal polysaccharides, and that these differences are sufficiently great to affect susceptibility to and outcome of IPD. The study recruited children aged 24-36 months, who had recovered from IPD, and age-matched healthy controls and vaccinated them with 1 dose of the 23-valent PPV to mimic natural exposure. The investigators collected serum samples after vaccination and analysed the dynamics of anti-polysaccharide antibody responses to several capsular antigens.

NCT ID: NCT03453177 Recruiting - Neonatal SEPSIS Clinical Trials

Intravenous and Oral Fosfomycin in Hospitalised Neonates With Clinical Sepsis

NeoFosfo
Start date: March 15, 2018
Phase: Phase 2
Study type: Interventional

Neonatal sepsis has a high risk of morbidity and mortality. The current WHO and national guidelines recommend antibiotics to which resistance is reported in neonatal populations, although the available data is limited. Research on alternative empirical regimens for neonatal sepsis which are affordable, safe and cost-effective, with a step-down oral option, is needed. AMR is an issue of global public health concern and is one of the WHO's global health priority areas. Understanding the benefits, risks, MIC capacity and PK of fosfomycin will influence global policy on the case management of neonates with sepsis in Kenya and international settings.

NCT ID: NCT03452111 Not yet recruiting - Healthy Clinical Trials

Study of Daily Application of Nestorone® (NES) and Testosterone (T) Combination Gel for Male Contraception

Start date: June 2018
Phase: Phase 2
Study type: Interventional

The long term objective is to develop a gel to be used as a male contraceptive.

NCT ID: NCT03448484 Recruiting - Stunting Clinical Trials

Cluster Randomized, Parallel-group, Prospective, Follow-up Effectiveness Study in Kenyan Children 6-35 Months

Start date: March 12, 2018
Phase: N/A
Study type: Interventional

Malnutrition is a public health problem in Kenya, with 26% of children under-five years of age stunted, and 26% of pre-school children, 26% of women of reproductive age and 42% of pregnant women being anaemic, respectively. Agriculture is the main source of income, food and nutrients for the majority of rural families in Sub-Saharan Africa including Kenya. Most farmers are smallholders and are vulnerable to poor nutrition. Thus far, programmes have mostly focused on increasing yields and household income, but not on improving nutritional status. One Acre Fund (1AF) has over the past 10 years successfully introduced an agriculture programme to smallholder farmers in Western Kenya focusing on improving harvest. 1AF is therefore well placed to transform an existing and successful agriculture programme into the world's largest 'nutrition network' for farmers, and it is the hope that a partnership between Children's Investment Fund Foundation (CIFF) and 1AF will create a strong voice for nutrition within the agriculture sector. The project aims to use an integrated programme by introducing nutrition-sensitive (improved water, sanitation and hygiene (WASH): e.g. soap for hand washing) and nutrition-specific (e.g. micronutrient supplements) components to 1AF's agricultural programme. The impact of such an integrated programme will be assessed in a cluster-randomized intervention study in children 6-35 months at recruitment comparing one group receiving the integrated intervention to another group receiving the agricultural intervention (already in place).

NCT ID: NCT03447210 Recruiting - Hepatitis C Clinical Trials

Study of HIV, HCV, APS and Phylogenetics for PWID

SHARP
Start date: February 26, 2018
Phase: N/A
Study type: Interventional

This study will determine whether assisted partner notification services (APS) can identify and link to care, the sexual and needle-sharing partners of HIV-infected and HIV/hepatitis C (HCV) co-infected persons who inject drugs (PWID). It will also define the risk factors for onward HIV and HCV transmission among PWID using viral phylogenetics.

NCT ID: NCT03435887 Recruiting - HIV Infections Clinical Trials

Piloting At-birth Point of Care HIV Testing Strategies in Kenya

Start date: December 2, 2016
Phase: N/A
Study type: Interventional

Innovative strategies to expedite HIV diagnosis among exposed infants, including at-birth testing and two portable point-of-care (POC) diagnostic systems, will be evaluated from an implementation framework. The programmatic impact of these tools on early infant diagnosis (EID) will be measured in comparison with parallel standard of care (SOC) HIV DNA PCR testing initiated at 6 weeks of age.